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Results for “Moderate to Severe Functional Impairments”

61 trials

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Showing 20 of 61 results

Early research (Phase 1)Looking for participantsNCT06952634
What this trial is testing

An Investigational Study of ESK-001 in Participants With Normal Liver Function and Participants With Mild, Moderate, and Severe Liver Damage

Who this might be right for
Hepatic Impairment
Alumis Inc 48
Early research (Phase 1)Looking for participantsNCT06908954
What this trial is testing

The Blood Levels of Palovarotene in Participants With Abnormal Liver Function Compared to Healthy Adult Participants After Intake of a Single Dose

Who this might be right for
Hepatic ImpairmentHealthy
Ipsen 32
Early research (Phase 1)Study completedNCT02108639
What this trial is testing

To Assess the Effect of Renal Impairment on the Blood Levels of Daclatasvir (DCV), Asunaprevir (ASV) and BMS-791325 After Multiple Doses of a Fixed Dose Combination Tablet

Who this might be right for
Hepatitis C
Bristol-Myers Squibb 41
Not applicableStudy completedNCT05912933
What this trial is testing

Learn About the Relationship Between Hepatic Impairment and Myelosuppression (Decreased Bone Marrow Function) in Breast Cancer Patients Treated With the Study Medicine Palbociclib (Pal-bow-sai-klib)

Who this might be right for
Breast Cancer
Pfizer 733
Early research (Phase 1)Study completedNCT02016911
What this trial is testing

Pharmacokinetics, Safety and Tolerability of Oral Semaglutide in Subjects With Hepatic Impairment

Who this might be right for
DiabetesDiabetes Mellitus, Type 2Healthy
Novo Nordisk A/S 56
Early research (Phase 1)Study completedNCT01766154
What this trial is testing

Pharmacokinetic Evaluation of Tirofiban Using a Single High-Dose Bolus In Subjects With Varying Degrees of Renal Function

Who this might be right for
Renal Insufficiency
Medicure 25
Early research (Phase 1)Study completedNCT03196206
What this trial is testing

Evaluate Pharmacokinetics and Safety of BMS-986177 in Participants With Normal Renal Function and With Moderate or Severe Renal Impairment

Who this might be right for
Thrombosis
Bristol-Myers Squibb 24
Early research (Phase 1)Study completedNCT04056468
What this trial is testing

Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Who this might be right for
Hepatic ImpairmentHealthy Volunteers
Millennium Pharmaceuticals, Inc. 24
Early research (Phase 1)Study completedNCT04656795
What this trial is testing

PK Study in Subjects With Renal Impairment (Severe and if Required Mild & Moderate) Compared to Subjects With Normal Renal Function

Who this might be right for
Renal ImpairmentNormal Renal Function
Tanabe Pharma America, Inc. 32
Early research (Phase 1)Study completedNCT03913000
What this trial is testing

Evaluate ID-085 in People With Mild, Moderate, and Severe Kidney Disease

Who this might be right for
Renal Impairment
Idorsia Pharmaceuticals Ltd. 32
Early research (Phase 1)Looking for participantsNCT04241835
What this trial is testing

Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Who this might be right for
Hepatic ImpairmentAdvanced Malignant Solid Tumor
Epizyme, Inc. 24
Early research (Phase 1)Study completedNCT03259087
What this trial is testing

Pharmacokinetics (PK) and Safety of a Single Intravenous (IV) Dose of MK-3866 in Participants With Impaired Renal Function and in Healthy Controls (MK-3866-005)

Who this might be right for
Renal Impairment
Merck Sharp & Dohme LLC 42
Early research (Phase 1)Study completedNCT02397707
What this trial is testing

Pharmacokinetics of Voxilaprevir in Adults With Normal Hepatic Function and Moderate or Severe Hepatic Impairment

Who this might be right for
HCV Infection
Gilead Sciences 33
Early research (Phase 1)Study completedNCT05718843
What this trial is testing

Test How Iclepertin is Taken up in the Blood of People With and Without Kidney Problems

Who this might be right for
Renal Insufficiency
Boehringer Ingelheim 36
Early research (Phase 1)Study completedNCT04190654
What this trial is testing

Single-dose Study to Investigate the Plasma PK of KW-6356 and Its Major Metabolite

Who this might be right for
Hepatic Impairment
Kyowa Kirin, Inc. 26
Early research (Phase 1)Not Yet RecruitingNCT07231991
What this trial is testing

Learn How the Body Processes the Study Medicine Called Vepdegestrant in People With Loss of Liver Function

Who this might be right for
Healthy Participants
Pfizer 24
Early research (Phase 1)Study completedNCT05718648
What this trial is testing

Test How BI 1015550 is Taken up in the Blood of People With and Without Kidney Problems

Who this might be right for
Renal InsufficiencyHealthy
Boehringer Ingelheim 26
Not applicableStudy completedNCT01000168
What this trial is testing

Treadmill Therapy and Brain Injuries

Who this might be right for
Cerebral StrokeHemiplegiaModerate to Severe Functional Impairments
Sunnaas Rehabilitation Hospital 60
Early research (Phase 1)Looking for participantsNCT07165002
What this trial is testing

The Pharmacokinetics and Safety of LY3537031 in Participants With Normal Liver Function and With Mild, Moderate, or Severe Liver Impairment

Who this might be right for
HealthyHepatic Insufficiency
Eli Lilly and Company 32
Testing effectiveness (Phase 2)Study completedNCT01082640
What this trial is testing

Effect of Febuxostat on Renal Function in Patients With Gout and Moderate to Severe Renal Impairment

Who this might be right for
Renal Impairment
Takeda 96
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