Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Moderate to Severe Osteoarthritis”

100 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 100 results

Large-scale testing (Phase 3)Study completedNCT01755546
What this trial is testing

Long-term Open-Label Safety Study to Evaluate EN3409

Who this might be right for
Low Back PainOsteoarthritisNeuropathic Pain
BioDelivery Sciences International 304
Large-scale testing (Phase 3)Study completedNCT01240863
What this trial is testing

Study to Evaluate the Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets (CEP-33237) for Relief of Moderate to Severe Pain in Patients With Osteoarthritis or Low Back Pain Who Require Opioid Treatment for an Extended Period of Time

Who this might be right for
Chronic Pain
Teva Branded Pharmaceutical Products R&D, Inc. 391
Testing effectiveness (Phase 2)Ended earlyNCT03706521
What this trial is testing

MRI Study to Evaluate the Safety and Efficacy of SM04690 for Knee Osteoarthritis

Who this might be right for
Knee Osteoarthritis
Biosplice Therapeutics, Inc. 13
Large-scale testing (Phase 3)Study completedNCT05603754
What this trial is testing

Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)

Who this might be right for
Knee Osteoarthritis
Biosplice Therapeutics, Inc. 499
Testing effectiveness (Phase 2)Study completedNCT02104050
What this trial is testing

Study of OLT1177 Gel to Treat Moderate to Severe OA Knee Pain

Who this might be right for
OsteoarthritisPain
Olatec Therapeutics, Inc. 202
Early research (Phase 1)Study completedNCT02095548
What this trial is testing

Phase 1, Dose Escalation Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SM04690 in Moderate to Severe Knee Osteoarthritis (OA)

Who this might be right for
Moderate to Severe Osteoarthritis
Biosplice Therapeutics, Inc. 61
Large-scale testing (Phase 3)Study completedNCT03429049
What this trial is testing

Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain

Who this might be right for
Osteoarthritis, Knee
Centrexion Therapeutics 332
Testing effectiveness (Phase 2)Study completedNCT03028870
What this trial is testing

Evaluate the Analgesic Efficacy and Safety of V120083 in Subjects With Osteoarthritis (OA) of the Knee

Who this might be right for
Osteo Arthritis Knee
Purdue Pharma LP 291
Testing effectiveness (Phase 2)Study completedNCT04875754
What this trial is testing

A Study Evaluating the Safety, Tolerability, and Range of Biologically Active Doses of ICM-203 in Mild to Moderate Knee Osteoarthritis

Who this might be right for
Osteoarthritis, Knee
ICM Biotech Australia Pty Ltd. 12
Testing effectiveness (Phase 2)Study completedNCT05216341
What this trial is testing

Study of OLP-1002 Injections for Reducing Moderate to Severe Pain Due to Osteoarthritis in Hip and/or Knee Joint

Who this might be right for
Osteoarthritis
OliPass Corporation 134
Large-scale testing (Phase 3)Study completedNCT00531427
What this trial is testing

Buprenorphine Transdermal System (BTDS) in Subjects w/Mod-sev Osteoarthritis (OA) Chronic Pain of Knee

Who this might be right for
Chronic PainOsteoarthritis of the Knee
Purdue Pharma LP 567
Large-scale testing (Phase 3)Ended earlyNCT03285646
What this trial is testing

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

Who this might be right for
Chronic Low Back PainOsteoarthritis
Regeneron Pharmaceuticals 63
Large-scale testing (Phase 3)Study completedNCT02462850
What this trial is testing

A Multi-Center Actual-Use Study on the Safety of CL 108 for the Treatment of Moderate to Severe Acute Pain Associated With Osteoarthritis of the Knee or Hip

Who this might be right for
PainNauseaVomiting
Charleston Laboratories, Inc 178
Testing effectiveness (Phase 2)Study completedNCT00669409
What this trial is testing

A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee

Who this might be right for
Osteoarthritis, Knee
Pfizer 83
Early research (Phase 1)Study completedNCT03513016
What this trial is testing

A Safety and Tolerability Study of UBX0101 in Patients With Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis, Knee
Unity Biotechnology, Inc. 78
Early research (Phase 1)Study completedNCT03542838
What this trial is testing

Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis

Who this might be right for
Osteoarthritis, KneePain, Knee
Sorrento Therapeutics, Inc. 94
Testing effectiveness (Phase 2)Ended earlyNCT01094262
What this trial is testing

A Safety and Tolerability Study of JNJ-42160443 in Patients With Moderate to Severe, Chronic Knee Pain From Osteoarthritis

Who this might be right for
OsteoarthritisOsteoarthritis, KneePain+2 more
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 196
Testing effectiveness (Phase 2)Study completedNCT01357837
What this trial is testing

Assessment of GRT6005 in Painful Osteoarthritis of the Knee

Who this might be right for
Osteoarthritis of the Knee
Tris Pharma, Inc. 207
Testing effectiveness (Phase 2)UnknownNCT01152125
What this trial is testing

Safety and Efficacy of Autologous Bone Marrow Stem Cells for Treating Osteoarthritis

Who this might be right for
Osteoarthritis
International Stemcell Services Limited 10
Large-scale testing (Phase 3)Study completedNCT00405691
What this trial is testing

Safety and Effectiveness Study of the TOPS System, a Total Posterior Arthroplasty Implant Designed to Alleviate Pain Resulting From Moderate to Severe Lumbar Stenosis

Who this might be right for
Low Back PainLeg PainSpondylolisthesis+1 more
Impliant, Ltd. 450
Next Page