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Results for “Mutation”

4,799 trials

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Showing 20 of 4,799 results

Testing effectiveness (Phase 2)WithdrawnNCT05279859
What this trial is testing

Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Hematologic Malignancies

Who this might be right for
Acute Myeloid Leukemia
Erasca, Inc.
Early research (Phase 1)UnknownNCT04448379
What this trial is testing

Efficacy and Safety of JMT101 Combined With Afatinib (or Osimertinib) in Patients With Non-Small Cell Lung Cancer

Who this might be right for
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Shanghai JMT-Bio Inc. 48
Not applicableUnknownNCT05133388
What this trial is testing

The Prevelence of HBB c.93-21 G-A in β Thalassemia Patients

Who this might be right for
Beta-Thalassemia
Assiut University 150
Not applicableLooking for participantsNCT04151342
What this trial is testing

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS)

Who this might be right for
CancerMalignancies MultipleMalignant Solid Tumor+7 more
University Health Network, Toronto 5,500
Early research (Phase 1)Ended earlyNCT03246854
What this trial is testing

DBPR112 in Patients With Head and Neck Cancer and EGFR Mutated Lung Cancer

Who this might be right for
Head and Neck CancerNSCLC
National Health Research Institutes, Taiwan 6
Not applicableUnknownNCT02309866
What this trial is testing

Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases

Who this might be right for
Retinitis Pigmentosa
Hillel Yaffe Medical Center 100
Not applicableWithdrawnNCT04007562
What this trial is testing

Acute Rhabdomyolysis and Muscle Pain Associated With Mutations in the LPIN1 Gene - A Retrospective Study Describing the Safety and Efficacy of Hydroxychloroquine Sulfate Given on a Compassionate Basis to Patients Suffering From Lipin-1 Deficiency

Who this might be right for
LIPIN1 Deficiency
Assistance Publique - Hôpitaux de Paris
Not applicableUnknownNCT05604573
What this trial is testing

DNA Mutation Detection in Circulating Tumor DNA and Tissue by mmADPS for Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Seoul National University Hospital 150
Large-scale testing (Phase 3)Looking for participantsNCT07207070
What this trial is testing

A Randomised, Open-label, Multicentre Phase III Clinical Study to Evaluate the Efficacy and Safety of JS105 Combined With Dalpiciclib and Fulvestrant Compared With Dalpiciclib and Fulvestrant in Patients With PIK3CA-mutated, HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer.

Who this might be right for
Breast Cancer
Risen (Suzhou) Pharma Tech Co., Ltd. 312
Not applicableUnknownNCT04909073
What this trial is testing

Observational Study of Afatinib 30 mg Daily

Who this might be right for
Non-Small Cell Lung CancerEpidermal Growth Factor Receptor Mutation
National University Hospital, Singapore 69
Not applicableEnded earlyNCT06140329
What this trial is testing

Natural History of Autosomal Dominant Optic Atrophy (ADOA), Caused by OPA1 Mutation

Who this might be right for
Autosomal Dominant Optic AtrophyOptic Atrophy, Autosomal DominantOptic Atrophies, Hereditary+1 more
PYC Therapeutics 1
Testing effectiveness (Phase 2)WithdrawnNCT02355431
What this trial is testing

Itacitinib in Combination With Erlotinib in Non Small Cell Lung Cancer Patients With Epidermal Growth Factor Receptor (EGFR) Activating Mutations

Who this might be right for
Solid Tumors and Hematologic MalignancyNSCLC (Non-small Cell Lung Carcinoma)
Incyte Corporation
Large-scale testing (Phase 3)UnknownNCT02387086
What this trial is testing

Gefitinib Combined With Thalidomide to Treat NSCLC

Who this might be right for
NSCLC
Bai Jun 380
Early research (Phase 1)Looking for participantsNCT06892054
What this trial is testing

Sotorasib Combined With First-line Chemotherapy for Advanced Pancreatic Adenocarcinoma

Who this might be right for
Pancreatic Adenocarcinoma
Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) 15
Not applicableStudy completedNCT01150305
What this trial is testing

Epidemiology of Non-syndromic Dominant Deafness

Who this might be right for
Hearing Impairment
Assistance Publique - Hôpitaux de Paris 183
Early research (Phase 1)Looking for participantsNCT06484556
What this trial is testing

T Cell Receptor Gene-Engineered T Cell Therapy Targeting KRAS Mutations in the Treatment of Subjects With Advanced Solid Tumor

Who this might be right for
Tumor, Solid
Tao Zhang 9
Not applicableStudy completedNCT06582537
What this trial is testing

LAMA2 Genetic Correction

Who this might be right for
MDC1A
Maastricht University 7
Not applicableStudy completedNCT02035046
What this trial is testing

Clinical Significance of Heterozygosity for Mutations of the SLC12A3 Gene Coding for the Thiazide Sensitive Na-Cl Cotransporter

Who this might be right for
Heterozygous Carriers of Gitelman Syndrome
Assistance Publique - Hôpitaux de Paris 250
Early research (Phase 1)Ended earlyNCT06130254
What this trial is testing

Phase Ib Trial of the KRAS G12C Inhibitor Adagrasib (MRTX849) in Combination With the PARP Inhibitor Olaparib in Patients With KRAS G12C Mutated Advanced Solid Tumors, With a Focus on Gynecological, Breast, Pancreatic and KEAP1 Mutated Non-small Cell Lung Cancers

Who this might be right for
Advanced Solid TumorNon-small Cell Lung Cancers
M.D. Anderson Cancer Center 1
Not applicableUnknownNCT03837054
What this trial is testing

Does Chemotherapy Train the Mutation of the Pig-A Gene? (PIGA)

Who this might be right for
Breast Cancer Female
Assistance Publique Hopitaux De Marseille 30
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