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Results for “Mutation”

4,531 trials

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Showing 20 of 4,531 results

Not applicableLooking for participantsNCT06643000
What this trial is testing

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal MetastasisEGFR Gene Mutation
Henan Cancer Hospital 60
Large-scale testing (Phase 3)Study completedNCT04058353
What this trial is testing

VX-445 Combination Therapy in Cystic Fibrosis (CF) Subjects Heterozygous for F508del and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 271
Testing effectiveness (Phase 2)Ended earlyNCT01109615
What this trial is testing

Pemetrexed and Gemcitabine for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations

Who this might be right for
Metastatic Colorectal Cancer
Vejle Hospital 40
Testing effectiveness (Phase 2)Study completedNCT01967576
What this trial is testing

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma

Who this might be right for
PheochromocytomaParaganglioma
National Cancer Institute (NCI) 14
Early research (Phase 1)Looking for participantsNCT06902376
What this trial is testing

XL092 and Cemiplimab in BRAF WT Thyroid Cancer

Who this might be right for
Anaplastic Thyroid CancerThyroid CancerBRAF Mutation-Related Tumors
UNC Lineberger Comprehensive Cancer Center 12
Large-scale testing (Phase 3)UnknownNCT06249997
What this trial is testing

An Open-Label Study to Assess the Safety & Efficacy of Leniolisib in Japanese Patients With APDS

Who this might be right for
APDS Gene Mutation
Pharming Technologies B.V. 3
Testing effectiveness (Phase 2)Looking for participantsNCT06316960
What this trial is testing

Safety and Efficacy of Avapritinib in Relapsed or Refractory Pediatric CBF-AML With KIT Mutation

Who this might be right for
AML, ChildhoodRelapse/RecurrenceRefractory AML+2 more
Children's Hospital of Soochow University 50
Testing effectiveness (Phase 2)WithdrawnNCT02115035
What this trial is testing

A Single Agent Study to Evaluate the Overall Response Rate, Safety and Tolerability of Orally Administered Vemurafenib

Who this might be right for
Multiple Myeloma
University of Arkansas
Large-scale testing (Phase 3)UnknownNCT02633189
What this trial is testing

Study Comparing Bevacizumab + Erlotinib vs Erlotinib Alone as First Line Treatment of Patients With EGFR Mutated Advanced Non Squamous Non Small Cell Lung Cancer

Who this might be right for
Non-squamous Non-small Cell Lung Cancer
National Cancer Institute, Naples 200
Not applicableLooking for participantsNCT01689584
What this trial is testing

COsegregation of VARiants in Panel of Genes

Who this might be right for
Gene Mutation-Related CancerGenetic Predisposition
Institut Curie 3,500
Large-scale testing (Phase 3)Study completedNCT01897233
What this trial is testing

Study of Lumacaftor in Combination With Ivacaftor in Subjects 6 Through 11 Years of Age With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 62
Testing effectiveness (Phase 2)Active Not RecruitingNCT04017650
What this trial is testing

Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer

Who this might be right for
BRAF NP_004324.2:p.V600EMetastatic Colon AdenocarcinomaMetastatic Microsatellite Stable Colorectal Carcinoma+13 more
M.D. Anderson Cancer Center 38
Testing effectiveness (Phase 2)Ended earlyNCT02285855
What this trial is testing

Metformin in Non Small Cell Lung Cancer (NSCLC)

Who this might be right for
Lung Cancer
M.D. Anderson Cancer Center 27
Testing effectiveness (Phase 2)Active Not RecruitingNCT04408625
What this trial is testing

Phase 1/2 Clinical Trial of LY3884963 in Patients With Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)

Who this might be right for
Frontotemporal Dementia
Prevail Therapeutics 35
Testing effectiveness (Phase 2)UnknownNCT02725918
What this trial is testing

Pemetrexed vs Pemetrexed Plus Cisplatin in EGFR-mutant NSCLC Patients After First Line EGFR-TKIs Failure

Who this might be right for
Non-small Cell Lung Cancer
Guangdong Association of Clinical Trials 150
Not applicableUnknownNCT02666755
What this trial is testing

Novel Detection System for Lung Cancer Curative Effect Monitoring

Who this might be right for
Lung Neoplasms
Jian Zhang 160
Early research (Phase 1)Not Yet RecruitingNCT07372625
What this trial is testing

Investigate the Effects of Multiple Doses of Rezatapopt on the Pharmacokinetics of Metformin, Rosuvastatin, Repaglinide, and Midazolam in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation.

Who this might be right for
TP53 Y220C MutationAdvanced Solid Tumors
PMV Pharmaceuticals, Inc 14
Not applicableStudy completedNCT01776918
What this trial is testing

Energy Requirements in Mitochondrial Disease

Who this might be right for
Mitochondrial DiseaseChronic Metabolic Disorder
University of British Columbia 23
Testing effectiveness (Phase 2)UnknownNCT05340413
What this trial is testing

Predicting Olaparib Sensitivity in Patients With Unresectable Locally Advanced/Metastatic HER2-negative Breast Cancer.

Who this might be right for
HER2-negative Breast CancerMetastatic Breast CancerTriple Negative Breast Cancer
SOLTI Breast Cancer Research Group 63
Not applicableEnrolling By InvitationNCT06470685
What this trial is testing

Prophylactic Prostatectomy for Prostate Cancer (PPPC)

Who this might be right for
Prostate CancerGenetic Predisposition to DiseaseBRCA Mutation
Royal Marsden NHS Foundation Trust 20
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