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Results for “Mutation Abnormality”

3,080 trials

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Showing 20 of 3,080 results

Not applicableLooking for participantsNCT06358222
What this trial is testing

Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan

Who this might be right for
CarcinomaNon-small Cell Lung Cancer
Shanghai Chest Hospital 200
Testing effectiveness (Phase 2)UnknownNCT04785729
What this trial is testing

Almonertinib Combined With Pyrotinib in the Treatment of Advanced NSCLC Patients With HER-2 Amplification/Mutation After EGFR-TKI Resistance

Who this might be right for
Safety
Sun Yat-sen University 36
Testing effectiveness (Phase 2)Study completedNCT02448329
What this trial is testing

Study of AZD1775 in Combination With Paclitaxel, in Advanced Gastric Adenocarcinoma Patients Harboring TP53 Mutation as a Second-line Chemotherapy

Who this might be right for
Advanced Gastric Adenocarcinoma
Samsung Medical Center 26
Not applicableStudy completedNCT05771454
What this trial is testing

Frequency of Occult Breast Cancer After Prophylactic Mastectomy Among High-Penetrance Breast Cancer Gene Positives

Who this might be right for
Genetic PredispositionBRCA MutationBreast Cancer+1 more
Aga Khan University Hospital, Pakistan 26
Not applicableUnknownNCT04388969
What this trial is testing

World Data on Ambroxol for Patients With GD and GBA Related PD

Who this might be right for
Gaucher DiseaseParkinson DiseaseGBA Gene Mutation
Shaare Zedek Medical Center 300
Early research (Phase 1)WithdrawnNCT01836341
What this trial is testing

Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With EGFR-Mutant Lung Cancers Undergoing Definitive Chemoradiation

Who this might be right for
Non-small Cell Lung Cancer
Memorial Sloan Kettering Cancer Center
Very early researchLooking for participantsNCT04741997
What this trial is testing

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

Who this might be right for
Melanoma Stage IIIMelanoma Stage IVBRAF V600 Mutation
H. Lee Moffitt Cancer Center and Research Institute 50
Not applicableStudy completedNCT01225679
What this trial is testing

Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene

Who this might be right for
Congenital Central Hypoventilation Syndrome
Associação Fundo de Incentivo à Pesquisa 1
Not applicableNo Longer AvailableNCT02624570
What this trial is testing

Midostaurin Access Program for Newly Diagnosed FLT3 (ITD or TKD) Mutated AML Adult Patients Eligible for Standard Induction and Consolidation Chemotherapy

Who this might be right for
Acute Myeloid Leukemia (AML) WithFLT3 Mutation, Internal Tandem Duplication (ITD) or Tyrosine Kinase Domain (TKD)
Novartis Pharmaceuticals
Post-approval studies (Phase 4)Ended earlyNCT02823470
What this trial is testing

A Pilot Study to Evaluate the Use of Smart Adherence Technology to Measure Lumacaftor/Ivacaftor Adherence in CF Subjects Homozygous for the F508del CFTR Mutation

Who this might be right for
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated 24
Early research (Phase 1)UnknownNCT05826483
What this trial is testing

Almonertinib in the First-line Treatment of Patients of NSCLC With Poor Performance Status

Who this might be right for
Malignant Tumor of LungPoor Performance Status
Guangzhou Institute of Respiratory Disease 20
Not applicableUnknownNCT04391283
What this trial is testing

First Line Osimertinib for EGFR Mutation-positive Non-Small Cell Lung Cancer in Real World Chinese Setting

Who this might be right for
Carcinoma, Non-Small-Cell Lung
First Affiliated Hospital of Zhejiang University 500
Not applicableLooking for participantsNCT07498829
What this trial is testing

Population Based Germline Testing for Early Detection and Prevention of Cancer

Who this might be right for
Breast Cancer RiskOvarian Cancer RiskCancer Gene Mutation
Queen Mary University of London 6,000
Not applicableStudy completedNCT02310451
What this trial is testing

Study of Molecular Mechanisms Implicated in the Pathogenesis of Melanoma. Role of Exosomes

Who this might be right for
Metastatic Melanoma
Centre Hospitalier Universitaire de Nice 15
Testing effectiveness (Phase 2)Study completedNCT04201756
What this trial is testing

Neoadjuvant Afatinib Therapy for Potentially Resectable Stage III EGFR Mutation-Positive Lung Adenocarcinoma

Who this might be right for
Lung Adenocarcinoma Stage IIIEGFR Gene Mutation
Shanghai Pulmonary Hospital, Shanghai, China 47
Testing effectiveness (Phase 2)Looking for participantsNCT03608631
What this trial is testing

IExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation

Who this might be right for
KRAS NP_004976.2:p.G12DMetastatic Pancreatic AdenocarcinomaPancreatic Ductal Adenocarcinoma+1 more
M.D. Anderson Cancer Center 28
Early research (Phase 1)Ended earlyNCT04849273
What this trial is testing

TPX-0131, a Novel Oral ALK Tyrosine Kinase Inhibitor, in Patients With ALK+ Advanced or Metastatic NSCLC

Who this might be right for
Non Small Cell Lung CancerNon-Small Cell Lung CancerNSCLC+3 more
Turning Point Therapeutics, Inc. 11
Testing effectiveness (Phase 2)Looking for participantsNCT06782542
What this trial is testing

Olutasidenib, Venetoclax, and Azacitidine in IDH1 Mutated Newly Diagnosed Acute Myeloid Leukemia Patients Eligible for Intensive Induction Chemotherapy

Who this might be right for
Acute Myeloid LeukemiaIDH1 Mutation
Justin Watts, MD 16
Not applicableNot Yet RecruitingNCT07503288
What this trial is testing

Genotype and Subtype Mapping of the Hepatitis C Virus

Who this might be right for
Hepatitis C VirusMutation AbnormalityRNA Positive+2 more
Assistance Publique - Hôpitaux de Paris 2,500
Testing effectiveness (Phase 2)Study completedNCT03625141
What this trial is testing

A Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma With Central Nervous System Metastases and Cobimetinib Plus Atezolizumab and Vemurafenib in BRAFV600 Mutation-positive Melanoma With Central Nervous System Metastases

Who this might be right for
Metastatic Melanoma
Hoffmann-La Roche 80
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