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Results for “Mutations”

4,055 trials

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Showing 20 of 4,055 results

Not applicableLooking for participantsNCT00359684
What this trial is testing

Use of Cysteamine in the Treatment of Cystinosis

Who this might be right for
Cystinosis
National Human Genome Research Institute (NHGRI) 330
Testing effectiveness (Phase 2)Looking for participantsNCT06383533
What this trial is testing

Disitamab Vedotin Plus Cadonilimab in Patients With HER2 Mutant Advanced or Metastatic Bile Duct Adenocarcinoma

Who this might be right for
Bile Duct Adenocarcinoma Non-ResectableHER2 Gene Mutation
Zhejiang Cancer Hospital 28
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Testing effectiveness (Phase 2)Ended earlyNCT01857271
What this trial is testing

Erlotinib Hydrochloride Before Surgery in Treating Patients With Stage III Non-Small Cell Lung Cancer

Who this might be right for
Stage IIIA Non-Small Cell Lung CancerStage IIIB Non-Small Cell Lung Cancer
Albert Einstein College of Medicine 3
Early research (Phase 1)Ended earlyNCT04835714
What this trial is testing

Find a Safe and Effective Dose of BI 1701963 Alone and in Combination With BI 3011441 in Patients With Advanced Cancer and a Certain Mutation (Kirsten Rat Sarcoma Viral Oncogene Homologue [KRAS])

Who this might be right for
Solid Tumors, KRAS Mutation
Boehringer Ingelheim 8
Early research (Phase 1)Study completedNCT04330664
What this trial is testing

Adagrasib in Combination With TNO155 in Patients With Cancer (KRYSTAL 2)

Who this might be right for
Advanced CancerMetastatic CancerMalignant Neoplastic Disease
Mirati Therapeutics Inc. 86
Not applicableStudy completedNCT04425200
What this trial is testing

Prevalence of HRR-related Genes Mutations and Prognosis in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients in Real World Setting

Who this might be right for
Prostatic Neoplasms
AstraZeneca 205
Post-approval studies (Phase 4)Study completedNCT02744664
What this trial is testing

Cryotherapy Combine Icotinib for Advanced NSCLC Treatment

Who this might be right for
Lung Neoplasms
Fuda Cancer Hospital, Guangzhou 60
Testing effectiveness (Phase 2)Study completedNCT00827684
What this trial is testing

Temsirolimus and Irinotecan for Treatment Resistant Patients With Metastatic Colorectal Cancer and KRAS Mutations

Who this might be right for
Metastatic Colorectal Cancer
Vejle Hospital 50
Large-scale testing (Phase 3)Study completedNCT02864251
What this trial is testing

Nivolumab + Chemotherapy or Nivolumab + Ipilimumab Versus Chemotherapy in Non-Small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Mutation Who Failed 1L or 2L EGFR Tyrosine Kinase Inhibitor (TKI) Therapy

Who this might be right for
Non-Small-Cell Lung Carcinoma
Bristol-Myers Squibb 367
Not applicableLooking for participantsNCT02432092
What this trial is testing

Pediatric Cardiomyopathy Mutation Analysis

Who this might be right for
CardiomyopathiesDilated CardiomyopathyHypertrophic Cardiomyopathy+3 more
Indiana University 300
Large-scale testing (Phase 3)Active Not RecruitingNCT03839771
What this trial is testing

Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy

Who this might be right for
Acute Myeloid LeukemiaMyelodysplastic Syndrome With Excess Blasts-2
Stichting Hemato-Oncologie voor Volwassenen Nederland 968
Early research (Phase 1)Study completedNCT03636204
What this trial is testing

A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin (GRN) Mutation

Who this might be right for
HealthyFrontotemporal Dementia
Alector Inc. 64
Testing effectiveness (Phase 2)Study completedNCT03812809
What this trial is testing

A Phase IIb Study of BPI-7711 Capsule in Non-small Cell Lung Cancer Patients With T790M Mutation Positive

Who this might be right for
NSCLC
Beta Pharma Shanghai 226
Not applicableNo Longer AvailableNCT04489433
What this trial is testing

Compassionate Use Program to Access Trametinib and Dabrafenib for Patients With BRAF Mutation-positive Metastatic Melanoma

Who this might be right for
Melanoma
Novartis Pharmaceuticals
Not applicableStudy completedNCT01773655
What this trial is testing

Clinical and Histopathologic Characteristics of BAP1 Mutations

Who this might be right for
Malignant Pleural Mesothelioma (MPM)Choroidal NevusPrimary Uveal Melanoma (UM)+3 more
Memorial Sloan Kettering Cancer Center 196
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05232006
What this trial is testing

PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers

Who this might be right for
Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
Assistance Publique - Hôpitaux de Paris 12
Testing effectiveness (Phase 2)Looking for participantsNCT07294144
What this trial is testing

Tofersen in Non-SOD1 ALS

Who this might be right for
ALS (Amyotrophic Lateral Sclerosis)
Washington University School of Medicine 30
Early research (Phase 1)UnknownNCT05019534
What this trial is testing

Tolerability and Safety of Vemurafenib, Cetuximab Combined With Camrelizumab for BRAF V600E-mutated /MSS Metastatic Colorectal Cancer

Who this might be right for
BRAF V600E-mutated /MSS Metastatic Colorectal CancerVemurafenib (BRAFi) Plus Cetuximab (EGFRi) Combined With PD-1 Monoclonal Antibody
West China Hospital 12
Not applicableUnknownNCT02738684
What this trial is testing

Predict Gefitinib' s Efficacy for Lung Cancer by Plasma Free Nucleic Acids EGFR Gene Mutation Test

Who this might be right for
Lung Adenocarcinoma
Southwest Hospital, China 100
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