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Results for “Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases”

38 trials

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Showing 20 of 38 results

Early research (Phase 1)Study completedNCT05665530
What this trial is testing

PRT2527 as Monotherapy and in Combination With Zanubrutinib or Venetoclax in Participants With R/R Hematologic Malignancies

Who this might be right for
Aggressive B-Cell Non-Hodgkin's Lymphoma (NHL)Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)Mantle Cell Lymphoma (MCL)+9 more
Prelude Therapeutics 86
Early research (Phase 1)Active Not RecruitingNCT04603001
What this trial is testing

Study of Oral LY3410738 in Patients With Advanced Hematologic Malignancies With IDH1 or IDH2 Mutations

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+1 more
Eli Lilly and Company 260
Testing effectiveness (Phase 2)Looking for participantsNCT05732961
What this trial is testing

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

Who this might be right for
Myelodysplastic SyndromesMyeloproliferative NeoplasmAnemia
H. Lee Moffitt Cancer Center and Research Institute 70
Early research (Phase 1)Ended earlyNCT04637009
What this trial is testing

TAS1553 in Subjects With Relapsed or Refractory Acute Myeloid Leukemia (AML) and Other Myeloid Neoplasms

Who this might be right for
Acute Myeloid LeukemiaMyeloproliferative NeoplasmMyelodysplastic/Myeloproliferative Neoplasm
Astex Pharmaceuticals, Inc. 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT05600894
What this trial is testing

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

Who this might be right for
Chronic Myelomonocytic LeukemiaMyelodysplastic SyndromeMyelodysplastic Syndrome With Excess Blasts+2 more
National Cancer Institute (NCI) 132
Testing effectiveness (Phase 2)Looking for participantsNCT06892223
What this trial is testing

Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation

Who this might be right for
Acute Myeloid LeukaemiaMDS (Myelodysplastic Syndrome)MPN (Myeloproliferative Neoplasms)
Istituto Clinico Humanitas 42
Testing effectiveness (Phase 2)Looking for participantsNCT06859424
What this trial is testing

A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

Who this might be right for
AML (Acute Myelogenous Leukemia)Acute Lymphoid Leukemia (ALL)Acute Leukemia (Category)+8 more
Center for International Blood and Marrow Transplant Research 358
Large-scale testing (Phase 3)Looking for participantsNCT04064060
What this trial is testing

Evaluate Long-term Safety in Participants Who Have Participated in Other Luspatercept (ACE-536) Clinical Trials

Who this might be right for
Myelodysplastic Syndromes (MDS)Beta-thalassemiaMyeloproliferative Neoplasm(MPN)-Associated Myelofibrosis
Celgene 665
Early research (Phase 1)Ended earlyNCT01066468
What this trial is testing

Glivec/Gleevec Pediatric (Age 1 to Less Than 4) PK Study in CML, Ph+ ALL Patients and Other Glivec/Gleevec® Indicated Hematological Disorders.

Who this might be right for
Chronic Myeloid Leukemia (CML)Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL)Other Glivec/Gleevec Indicated Hematological Disorders (HES, CEL, MDS/ MPN)
Novartis Pharmaceuticals 3
Testing effectiveness (Phase 2)Ended earlyNCT02587598
What this trial is testing

Study of INCB053914 in Subjects With Advanced Malignancies

Who this might be right for
Solid Tumors
Incyte Corporation 97
Not applicableLooking for participantsNCT07143669
What this trial is testing

Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations

Who this might be right for
Clonal Mast Cell DiseaseKIT D816V MutationSuspected KITD816V Mutated Clonal Mast Cell Disease
Blueprint Medicines Corporation 450
Early research (Phase 1)Ended earlyNCT02663518
What this trial is testing

A Trial of PF-07901800 (TTI-621) for Patients With Hematologic Malignancies and Selected Solid Tumors

Who this might be right for
Hematologic MalignanciesSolid Tumor
Pfizer 249
Testing effectiveness (Phase 2)Ended earlyNCT04866056
What this trial is testing

Jaktinib and Azacitidine In Treating Patients With MDS With MF or MDS/MPN With MF.

Who this might be right for
Myelodysplastic SyndromesMyeloproliferative NeoplasmsMyelofibrosis
Suzhou Zelgen Biopharmaceuticals Co.,Ltd 1
Early research (Phase 1)WithdrawnNCT02564536
What this trial is testing

Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)

Who this might be right for
Chronic Myelomonocytic LeukemiaJuvenile Myelomonocytic LeukemiaAtypical Chronic Myeloid Leukemia+3 more
Washington University School of Medicine
Early research (Phase 1)Looking for participantsNCT04771572
What this trial is testing

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Who this might be right for
Non Hodgkin LymphomaRichter TransformationMultiple Myeloma+10 more
Newave Pharmaceutical Inc 100
Early research (Phase 1)Looking for participantsNCT05549661
What this trial is testing

Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap Neoplasms

Who this might be right for
Recurrent Chronic Myelomonocytic LeukemiaRefractory Chronic Myelomonocytic LeukemiaMyelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified+3 more
Mayo Clinic 25
Testing effectiveness (Phase 2)Study completedNCT01606579
What this trial is testing

Safety and Efficacy Study of PRI-724 in Subjects With Advanced Myeloid Malignancies

Who this might be right for
Acute Myeloid LeukemiaChronic Myeloid Leukemia
Prism Pharma Co., Ltd. 49
Not applicableEnded earlyNCT01688011
What this trial is testing

Connect® Myeloid Disease Registry

Who this might be right for
Primary MyelofibrosisMyelodysplastic SyndromesLeukemia, Myeloid, Acute
Celgene 2,013
Testing effectiveness (Phase 2)Ended earlyNCT04639024
What this trial is testing

ADCT-301 in Patients With R/R AML, MDS, or MDS/MPN

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Myeloproliferative Neoplasm (MDS/MPN)
Gwynn Long, M.D. 3
Early research (Phase 1)Active Not RecruitingNCT03613532
What this trial is testing

Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN

Who this might be right for
Acute Myeloid Leukemia (AML)Myelodysplastic Syndrome (MDS)Chronic Myelomonocytic Leukemia (CMML)+2 more
Jacqueline Garcia, MD 102
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