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Results for “NRF2 Mutation”

4 trials

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Showing 4 of 4 results

Testing effectiveness (Phase 2)Ended earlyNCT04265534
What this trial is testing

KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC

Who this might be right for
Non-Small Cell Lung CancerNon-squamous Non-small-cell Lung CancerNon-Squamous Non-Small Cell Neoplasm of Lung+3 more
Calithera Biosciences, Inc 40
Not applicableEnded earlyNCT04698681
What this trial is testing

NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes for the KEAPSAKE (CX-839-014) Trial

Who this might be right for
Non-Small Cell Lung CancerNon-squamous Non-small-cell Lung CancerNon-Squamous Non-Small Cell Neoplasm of Lung+3 more
Calithera Biosciences, Inc 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT03872427
What this trial is testing

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmNF1 Mutation Positive Malignant Peripheral Nerve Sheath Tumor+1 more
National Cancer Institute (NCI) 54
Testing effectiveness (Phase 2)Ended earlyNCT05275673
What this trial is testing

Sapanisertib in Relapsed/Refractory NFE2L2-Mutated and Wild-Type Squamous Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung CancerSquamous Non-small-cell Lung CancerSquamous Non-Small Cell Neoplasm of Lung+1 more
Faeth Therapeutics 7