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Results for “NRG1 Fusion”

14 trials

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Showing 14 of 14 results

Testing effectiveness (Phase 2)Ended earlyNCT05588609
What this trial is testing

Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers

Who this might be right for
NSCLC Harboring NRG1 FusionMetastatic Castration-resistant Prostate Cancer
Merus B.V. 13
Not applicableApproved For MarketingNCT04100694
What this trial is testing

Early Access Program Providing HER2/HER3 Bispecific Antibody, MCLA-128, for a Patient With Advanced NRG1-Fusion Positive Solid Tumor

Who this might be right for
NRG1 FusionPancreatic CancerNon Small Cell Lung Cancer+8 more
Merus B.V.
Not applicableNo Longer AvailableNCT05107193
What this trial is testing

Afatinib (GILOTRIF®) in Patients Suffering From Tumors Harboring Neuregulin 1 (NRG1) Gene Alterations (Specifically NRG1 Gene Fusion-positive Advanced Solid Tumors)

Who this might be right for
Solid Tumors
Boehringer Ingelheim
Testing effectiveness (Phase 2)Ended earlyNCT03805841
What this trial is testing

Study of Tarloxotinib in Pts With NSCLC (EGFR Exon 20 Insertion, HER2-activating Mutations) & Other Solid Tumors With NRG1/ERBB Gene Fusions

Who this might be right for
NSCLC, Stage IVNSCLC Stage IIIBNSCLC, Stage IIIC+5 more
Rain Oncology Inc 41
Testing effectiveness (Phase 2)Ended earlyNCT04383210
What this trial is testing

Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors

Who this might be right for
Locally Advanced Solid TumorMetastatic Solid TumorPancreatic Cancer+14 more
Elevation Oncology 54
Not applicableStudy completedNCT04750824
What this trial is testing

Real-World Effectiveness of Afatinib (Gilotrif) Following Immunotherapy in the Treatment of Metastatic, Squamous Cell Carcinoma of the Lung: A Multi-Site Retrospective Chart Review Study in the U.S.

Who this might be right for
Non-squamous, Non-Small Cell Lung Cancer
Boehringer Ingelheim 110
Testing effectiveness (Phase 2)Active Not RecruitingNCT05057013
What this trial is testing

A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours

Who this might be right for
Bladder CancerTriple Negative Breast CancerCastration-resistant Prostate Cancer+11 more
Cancer Research UK 81
Testing effectiveness (Phase 2)Active Not RecruitingNCT02912949
What this trial is testing

Zenocutuzumab (MCLA-128) in Patients With Solid Tumors Harboring an NRG1 Fusion (eNRGy)

Who this might be right for
Solid Tumours Harboring NRG1 FusionNSCLC Harboring NRG1 FusionPancreatic Cancer Harboring NRG1 Fusion+1 more
Partner Therapeutics, Inc. 250
Testing effectiveness (Phase 2)Looking for participantsNCT06383884
What this trial is testing

Patritumab Deruxtecan in Patients With Solid Tumor Harboring an NRG1 Fusion

Who this might be right for
Solid Tumor, Adult
Samsung Medical Center 30
Not applicableEnrolling By InvitationNCT07122882
What this trial is testing

Integrated Genomics in Oncogene-driven NSCLC With Acquired Resistance

Who this might be right for
Oncogene-addicted Non Small Cell Lung CancerEGFR MutationALK Fusion-positive Solid or CNS Tumors+10 more
Chang Gung Memorial Hospital 40
Testing effectiveness (Phase 2)Study completedNCT04790695
What this trial is testing

Single Patient Protocol for an NRG1 Fusion Positive Metastatic Pancreatic Cancer Patient Using Seribantumab

Who this might be right for
Metastatic Pancreatic Cancer
Ottawa Hospital Research Institute 1
Early research (Phase 1)Looking for participantsNCT07361562
What this trial is testing

A Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumor, AdultERBB2 Altered Breast CancerERBB2 Gene Amplification+3 more
Cogent Biosciences, Inc. 100
Early research (Phase 1)Active Not RecruitingNCT05919537
What this trial is testing

Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation

Who this might be right for
Non-Small Cell Lung CancerPancreatic CancerLocally Advanced Solid Tumor+1 more
Hummingbird Bioscience 68
Post-approval studies (Phase 4)UnknownNCT04814056
What this trial is testing

To Evaluate the Efficacy of Afatinib in the Treatment of Locally Advanced/Metastatic Non-Small Cell Lung Cancer With NRG1 Fusion

Who this might be right for
NRG1-fused Non-small Cell Lung Cancer
Shanghai Chest Hospital 15