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Results for “Neoantigens”

29 trials

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Showing 20 of 29 results

Very early researchEnrolling By InvitationNCT07316361
What this trial is testing

GYNORYLAQ™-VLINIVAL™: Ψ-Guided Personalized Neoantigen Peptide Vaccine for High-Risk Endometrial Cancer

Who this might be right for
Endometrial CarcinomaEndometrial Carcinoma Stage III
Biogenea Pharmaceuticals Ltd. 40
Not applicableUnknownNCT05498194
What this trial is testing

Computational Prediction and Experimental Validation of Gastric Cancer Associated Neoantigens

Who this might be right for
Gastric CancerNeoantigens
University Medical Center Ho Chi Minh City (UMC) 50
Early research (Phase 1)Ended earlyNCT04596033
What this trial is testing

TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy

Who this might be right for
MelanomaNon-small Cell Lung CancerSquamous Cell Carcinoma of Head and Neck+6 more
Genocea Biosciences, Inc. 49
Very early researchStudy completedNCT02113657
What this trial is testing

T-Cell Responses to Neoantigens Post Treatment With Ipilimumab in Men With Metastatic Castration-Resistant Prostate Cancer

Who this might be right for
Prostate Cancer
M.D. Anderson Cancer Center 30
Very early researchLooking for participantsNCT06577532
What this trial is testing

Study of KRAS Neoantigen mRNA Vaccine (ABO2102) in Patients With KRAS -Mutated Solid Tumors

Who this might be right for
Pancreatic NeoplasmsOther Solid Tumors
Ruijin Hospital 56
Testing effectiveness (Phase 2)Looking for participantsNCT05908643
What this trial is testing

A First-In-Human Trial of pTTL in Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer
Neogap Therapeutics AB 16
Not applicableNo Longer AvailableNCT04194190
What this trial is testing

A Single Patient Will be Treated With Individual Patient TCR-Transduced PBL

National Institutes of Health Clinical Center (CC)
Not applicableUnknownNCT05498168
What this trial is testing

Computational Prediction and Experimental Validation of Esophageal Cancer Associated Neoantigens

Who this might be right for
Esophageal CancerNeoantigen
University Medical Center Ho Chi Minh City (UMC) 50
Testing effectiveness (Phase 2)Looking for participantsNCT03412877
What this trial is testing

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Who this might be right for
Endocrine TumorsNon-Small Cell Lung CancerOvarian Cancer+4 more
National Cancer Institute (NCI) 285
Testing effectiveness (Phase 2)Ended earlyNCT03300843
What this trial is testing

Ability of a Dendritic Cell Vaccine to Immunize Melanoma or Epithelial Cancer Patients Against Defined Mutated Neoantigens Expressed by the Autologous Cancer

Who this might be right for
MelanomaGastrointestinal CancerBreast Cancer+2 more
National Cancer Institute (NCI) 1
Not applicableLooking for participantsNCT05030805
What this trial is testing

Transcriptional Map of Ovarian Cancer at the Single Cell Level

Who this might be right for
Ovarian Cancer
University Hospital, Strasbourg, France 50
Early research (Phase 1)Looking for participantsNCT06904066
What this trial is testing

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Who this might be right for
Malignancy, HematologicNeoplasms, HematologicNeoplasms, Hematopoietic+8 more
National Cancer Institute (NCI) 86
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07412197
What this trial is testing

Preventive Dendritic Cell Vaccination for Lynch Syndrome

Who this might be right for
Lynch Syndrome
Radboud University Medical Center 23
Testing effectiveness (Phase 2)Study completedNCT03559413
What this trial is testing

Patient-individualized Peptide Vaccination Based on Tumor-specific Mutations in Children and Young Adults With Primary/Relapsed ALL

Who this might be right for
Primary/Relapsed Acute Lymphoblastic Leukemia (ALL) of Childhood, Adolescents and Young Adults
University Children's Hospital Tuebingen 30
Early research (Phase 1)Active Not RecruitingNCT05349890
What this trial is testing

Personalized TCR-T: Study of Adoptively Transferred T-cell Receptor Gene-engineered T Cells (TCR-T)

Who this might be right for
Malignant Epithelial Neoplasms
Providence Health & Services 1
Testing effectiveness (Phase 2)Ended earlyNCT03480152
What this trial is testing

Messenger RNA (mRNA)-Based, Personalized Cancer Vaccine Against Neoantigens Expressed by the Autologous Cancer

Who this might be right for
MelanomaColon CancerGastrointestinal Cancer+2 more
National Cancer Institute (NCI) 5
Not applicableNo Longer AvailableNCT04135092
What this trial is testing

Single Patient Protocol: A Phase II Study Using the Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab

National Institutes of Health Clinical Center (CC)
Testing effectiveness (Phase 2)WithdrawnNCT03130764
What this trial is testing

Durvalumab and Tremelimumab for Adjuvant Therapy of Resected NSCLC

Who this might be right for
Non-small Cell Lung Cancer
Columbia University
Testing effectiveness (Phase 2)WithdrawnNCT05456165
What this trial is testing

Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer

Who this might be right for
Colonic NeoplasmsColorectal Neoplasms
Gritstone bio, Inc.
Not applicableUnknownNCT04145232
What this trial is testing

AImmune - Artificial Intelligence Algorithm for Identification of Immunogenic Neoepitopes of Cancer to Predict and Boost Patient's Response to Immunotherapies.

Who this might be right for
Non Small Cell Lung CancerNeoepitopesNeoantigens+3 more
Ardigen 30
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