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Results for “Neoantigens”

31 trials

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Showing 20 of 31 results

Testing effectiveness (Phase 2)Looking for participantsNCT07368803
What this trial is testing

Evaluation of the Safety, Tolerability and Efficacy of iNeo-Vac-R01, an Individualized mRNA Therapeutic Technology Based on Tumor Neoantigens, for Adjuvant Treatment in Patients With Biliary Malignant Tumors After Radical Resection

Who this might be right for
Biliary Malignant Tumors
Yifan Wang 20
Large-scale testing (Phase 3)Not Yet RecruitingNCT07609901
What this trial is testing

Preventive Dendritic Cell Vaccination for Lynch Syndrome Carriers

Who this might be right for
Lynch Syndrome
Radboud University Medical Center 372
Not applicableUnknownNCT04145232
What this trial is testing

AImmune - Artificial Intelligence Algorithm for Identification of Immunogenic Neoepitopes of Cancer to Predict and Boost Patient's Response to Immunotherapies.

Who this might be right for
Non Small Cell Lung CancerNeoepitopesNeoantigens+3 more
Ardigen 30
Very early researchEnrolling By InvitationNCT07316361
What this trial is testing

GYNORYLAQ™-VLINIVAL™: Ψ-Guided Personalized Neoantigen Peptide Vaccine for High-Risk Endometrial Cancer

Who this might be right for
Endometrial CarcinomaEndometrial Carcinoma Stage III
Biogenea Pharmaceuticals Ltd. 40
Early research (Phase 1)Study completedNCT07504484
What this trial is testing

Safety and Efficacy of Neoantigen-Based Personalized Immunotherapy as Consolidation Therapy After Standard Adjuvant Treatment in Resectable Stage III Colorectal Cancer or Non-Small Cell Lung Cancer

Who this might be right for
CRC (Colorectal Cancer)Non Small Lung Cancer
Ying Yuan, MD 6
Testing effectiveness (Phase 2)WithdrawnNCT04536922
What this trial is testing

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Mutated or Viral Neoantigens in a Patient With Metastatic Cancer Plus the Administration of Pembrolizumab

Who this might be right for
Metastatic HPV-16 Positive Squamous Cell Anal Cancer
National Cancer Institute (NCI)
Very early researchLooking for participantsNCT06577532
What this trial is testing

Study of KRAS Neoantigen mRNA Vaccine (ABO2102) in Patients With KRAS -Mutated Solid Tumors

Who this might be right for
Pancreatic NeoplasmsOther Solid Tumors
Ruijin Hospital 56
Testing effectiveness (Phase 2)Looking for participantsNCT04912765
What this trial is testing

Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC

Who this might be right for
Hepatocellular CarcinomaHepatocellular CancerColorectal Cancer+2 more
National Cancer Centre, Singapore 60
Early research (Phase 1)Ended earlyNCT04596033
What this trial is testing

TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy

Who this might be right for
MelanomaNon-small Cell Lung CancerSquamous Cell Carcinoma of Head and Neck+6 more
Genocea Biosciences, Inc. 49
Very early researchStudy completedNCT02113657
What this trial is testing

T-Cell Responses to Neoantigens Post Treatment With Ipilimumab in Men With Metastatic Castration-Resistant Prostate Cancer

Who this might be right for
Prostate Cancer
M.D. Anderson Cancer Center 30
Testing effectiveness (Phase 2)Looking for participantsNCT03412877
What this trial is testing

Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

Who this might be right for
Endocrine TumorsNon-Small Cell Lung CancerOvarian Cancer+4 more
National Cancer Institute (NCI) 285
Testing effectiveness (Phase 2)Looking for participantsNCT05908643
What this trial is testing

A First-In-Human Trial of pTTL in Advanced Colorectal Cancer

Who this might be right for
Colorectal Cancer
Neogap Therapeutics AB 16
Testing effectiveness (Phase 2)Ended earlyNCT03300843
What this trial is testing

Ability of a Dendritic Cell Vaccine to Immunize Melanoma or Epithelial Cancer Patients Against Defined Mutated Neoantigens Expressed by the Autologous Cancer

Who this might be right for
MelanomaGastrointestinal CancerBreast Cancer+2 more
National Cancer Institute (NCI) 1
Testing effectiveness (Phase 2)Study completedNCT03559413
What this trial is testing

Patient-individualized Peptide Vaccination Based on Tumor-specific Mutations in Children and Young Adults With Primary/Relapsed ALL

Who this might be right for
Primary/Relapsed Acute Lymphoblastic Leukemia (ALL) of Childhood, Adolescents and Young Adults
University Children's Hospital Tuebingen 30
Testing effectiveness (Phase 2)Study completedNCT03953235
What this trial is testing

A Personalized Cancer Vaccine Targeting Shared Neoantigens

Who this might be right for
Non-Small Cell Lung CancerColorectal CancerPancreatic Cancer+2 more
Gritstone bio, Inc. 39
Testing effectiveness (Phase 2)WithdrawnNCT04102436
What this trial is testing

Non-Viral TCR Gene Therapy

Who this might be right for
Endocrine/NeuroendocrineNon-Small Cell Lung CancerBreast Cancer+2 more
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)WithdrawnNCT05456165
What this trial is testing

Study of an Individualized Vaccine Targeting Neoantigens in Combination With Immune Checkpoint Blockade for Patients With Colon Cancer

Who this might be right for
Colonic NeoplasmsColorectal Neoplasms
Gritstone bio, Inc.
Not applicableNo Longer AvailableNCT04194190
What this trial is testing

A Single Patient Will be Treated With Individual Patient TCR-Transduced PBL

National Institutes of Health Clinical Center (CC)
Early research (Phase 1)UnknownNCT03258359
What this trial is testing

Personalized Adoptive Cellular Therapy Targeting MDS Stem Cell Neoantigens (PACTN)

Who this might be right for
Myelodysplastic Syndromes
PersImmune, Inc 12
Not applicableUnknownNCT05498168
What this trial is testing

Computational Prediction and Experimental Validation of Esophageal Cancer Associated Neoantigens

Who this might be right for
Esophageal CancerNeoantigen
University Medical Center Ho Chi Minh City (UMC) 50
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