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Results for “Neratinib”

79 trials

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Showing 20 of 79 results

Early research (Phase 1)Study completedNCT00757809
What this trial is testing

Study Evaluating The Tolerability Of Multiple Doses Of HKI-272

Who this might be right for
Healthy Subjects
Puma Biotechnology, Inc. 50
Testing effectiveness (Phase 2)Study completedNCT01008150
What this trial is testing

Phase II Randomized Trial Evaluating Neoadjuvant Therapy With Neratinib and/or Trastuzumab Followed by Postoperative Trastuzumab in Women With Locally Advanced HER2-positive Breast Cancer

Who this might be right for
Breast Cancer
NSABP Foundation Inc 141
Not applicableNo Longer AvailableNCT01956253
What this trial is testing

Single Subject Neratinib in Bladder Cancer (NRR)

Who this might be right for
Bladder Cancer
UNC Lineberger Comprehensive Cancer Center
Testing effectiveness (Phase 2)Ended earlyNCT01953926
What this trial is testing

Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations

Who this might be right for
Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations
Puma Biotechnology, Inc. 582
Early research (Phase 1)Temporarily pausedNCT05372614
What this trial is testing

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

Who this might be right for
Metastatic Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
National Cancer Institute (NCI) 33
Testing effectiveness (Phase 2)Study completedNCT01827267
What this trial is testing

Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Cancer

Who this might be right for
HER2-mutant Non-Small Cell Lung Cancer
Puma Biotechnology, Inc. 62
Large-scale testing (Phase 3)Looking for participantsNCT05760612
What this trial is testing

Adjuvant Trastuzumab Plus Neratinib in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer After Neoadjuvant Trastuzumab Plus Pertuzumab

Who this might be right for
Early-stage Breast CancerHER2-positive Breast CancerAdjuvant Treatment After Trastuzumab+2 more
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University 300
Early research (Phase 1)Study completedNCT02334501
What this trial is testing

Open-label PK Study to Evaluate Lansoprazole and Neratinib in Healthy Subjects

Who this might be right for
Healthy
Puma Biotechnology, Inc. 15
Testing effectiveness (Phase 2)WithdrawnNCT01960023
What this trial is testing

Safety and Efficacy Study of Neratinib and Cetuximab to Treat Patients With Quadruple Wild-Type Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
NSABP Foundation Inc
Early research (Phase 1)Ended earlyNCT02593708
What this trial is testing

Phase1 of Neratinib+Trastuzumab, Pertuzumab, Paclitaxel in Patients With Advanced Solid Tumors/HER2+

Who this might be right for
Solid Tumor
Michelle Melisko 6
Testing effectiveness (Phase 2)Looking for participantsNCT05919108
What this trial is testing

Neoadjuvant Neratinib in Stage I-III HER2-Mutated Lobular Breast Cancers

Who this might be right for
Anatomic Stage I Breast CancerAnatomic Stage II Breast CancerAnatomic Stage III Breast Cancer+1 more
Vanderbilt-Ingram Cancer Center 30
Early research (Phase 1)Active Not RecruitingNCT04502602
What this trial is testing

Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer

Who this might be right for
Advanced Solid TumorOvarian Cancer
Virginia Commonwealth University 18
Not applicableStudy completedNCT05599334
What this trial is testing

A Retrospective Observational Study of Patients With Early-stage HER2-positive Breast Cancer, Treated With Neratinib

Who this might be right for
Breast CancerAdjuvant TherapyHER2-positive Breast Cancer
Pierre Fabre Medicament 111
Testing effectiveness (Phase 2)Study completedNCT01111825
What this trial is testing

Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer

Who this might be right for
Breast Cancer
Puma Biotechnology, Inc. 99
Testing effectiveness (Phase 2)Study completedNCT00706030
What this trial is testing

Study Evaluating Neratinib (HKI-272) In Combination With Vinorelbine In Subjects With Solid Tumors And Metastatic Breast Cancer

Who this might be right for
Breast CancerAdvanced Malignant Solid Tumors
Puma Biotechnology, Inc. 92
Not applicableLooking for participantsNCT06693024
What this trial is testing

Adjuvant Therapy With Neratinib in HER2 Positive Early Breast Cancer

Who this might be right for
HER2-positive Breast Cancer
Shu Wang 2,806
Testing effectiveness (Phase 2)Active Not RecruitingNCT05252988
What this trial is testing

Three Antidiarrheal Strategies in HER2+/HR+ Early Breast Cancer Patients Treated With Extended Adjuvant Neratinib

Who this might be right for
Early-stage Breast CancerHER2 Positive Breast CancerHormone Receptor Positive
Spanish Breast Cancer Research Group 177
Testing effectiveness (Phase 2)Study completedNCT01670877
What this trial is testing

Neratinib +/- Fulvestrant in Metastatic HER2 Non-amplified But HER2 Mutant Breast Cancer

Who this might be right for
Breast Neoplasms
Washington University School of Medicine 56
Testing effectiveness (Phase 2)UnknownNCT03812393
What this trial is testing

Evaluating the Efficacy of Neratinib on Live Cell HER2 Signaling Transduction Analysis Positive Triple Negative Breast

Who this might be right for
Triple Negative Breast CancerEarly-stage Breast CancerHER2-positive Breast Cancer
West Cancer Center 27
Early research (Phase 1)Active Not RecruitingNCT03065387
What this trial is testing

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Who this might be right for
Advanced Malignant Solid NeoplasmEGFR Gene AmplificationEGFR Gene Mutation+7 more
M.D. Anderson Cancer Center 93
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