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Results for “Neratinib”

79 trials

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Showing 20 of 79 results

Early research (Phase 1)Study completedNCT02334501
What this trial is testing

Open-label PK Study to Evaluate Lansoprazole and Neratinib in Healthy Subjects

Who this might be right for
Healthy
Puma Biotechnology, Inc. 15
Not applicableEnded earlyNCT03786107
What this trial is testing

HER-Seq: A Blood-based Screening Study to Identify Patients With HER2 Mutations for Enrollment Into Clinical Research Studies of Neratinib

Who this might be right for
Hormone Receptor-Positive, HER2-Negative Metastatic Breast CancerMetastatic Cervical Cancer
Puma Biotechnology, Inc. 1,583
Early research (Phase 1)Study completedNCT00781430
What this trial is testing

Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease

Who this might be right for
Hepatic Insufficiency
Puma Biotechnology, Inc. 27
Testing effectiveness (Phase 2)Study completedNCT00741260
What this trial is testing

Study Evaluating The Combination Of Neratinib And Capecitabine In Solid Tumors And Breast Cancer

Who this might be right for
Breast Cancer
Puma Biotechnology, Inc. 105
Testing effectiveness (Phase 2)Study completedNCT02236000
What this trial is testing

A Dose-Escalation Study Evaluating the Combination of Trastuzumab Emtansine (T-DM1) With Neratinib in Women With Metastatic HER2-Positive Breast Cancer

Who this might be right for
Breast Cancer
NSABP Foundation Inc 49
Testing effectiveness (Phase 2)WithdrawnNCT04901299
What this trial is testing

Fulvestrant + Neratinib In Breast Cancer

Who this might be right for
Stage IV (Metastatic) Breast CancerMetastatic Breast CancerER Positive Breast Cancer+3 more
Massachusetts General Hospital
Early research (Phase 1)Study completedNCT00838539
What this trial is testing

Study Evaluating Neratinib In Combination With Temsirolimus In Subjects With Solid Tumors

Who this might be right for
NeoplasmsMalignant Carcinoma
Puma Biotechnology, Inc. 63
Testing effectiveness (Phase 2)WithdrawnNCT05512182
What this trial is testing

Efficacy of Triplet Combination With Pembrolizumab, Neratinib, and Paclitaxel as a Second Line Treatment in Recurrent/Advanced Gastric Cancer Having Somatic Human Epidermal Growth Factor Receptor Family (EGFR, HER2, HER3, HER4) Mutations or HER2 Amplification/Overexpression

Who this might be right for
Recurrent/Advanced Gastric Cancer
Yonsei University
Not applicableNot Yet RecruitingNCT07019272
What this trial is testing

Neratinib in Extended Adjuvant Treatment for HER2+ Early Breast Cancer With pCR But High-Risk Features: A Hebei Multi-Center Real-World Study

Who this might be right for
HER2-positive Breast Cancer
Hebei Medical University Fourth Hospital 170
Testing effectiveness (Phase 2)Study completedNCT01494662
What this trial is testing

HKI-272 for HER2-Positive Breast Cancer and Brain Metastases

Who this might be right for
Breast Cancer
Dana-Farber Cancer Institute 140
Not applicableLooking for participantsNCT06693024
What this trial is testing

Adjuvant Therapy With Neratinib in HER2 Positive Early Breast Cancer

Who this might be right for
HER2-positive Breast Cancer
Shu Wang 2,806
Testing effectiveness (Phase 2)Study completedNCT03094052
What this trial is testing

Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and Neratinib

Who this might be right for
HER2-positive Breast CancerBreast AdenocarcinomaStage II Breast Cancer AJCC v6 and v7+6 more
University of California, San Francisco 11
Testing effectiveness (Phase 2)Ended earlyNCT03101748
What this trial is testing

Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

Who this might be right for
Breast Inflammatory CarcinomaLocally Advanced Breast CarcinomaMetastatic Breast Carcinoma+5 more
M.D. Anderson Cancer Center 34
Early research (Phase 1)Looking for participantsNCT05274048
What this trial is testing

Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

Who this might be right for
Gastric CancerGastrointestinal CancerHER2 Gene Mutation
Fox Chase Cancer Center 18
Testing effectiveness (Phase 2)Looking for participantsNCT04886531
What this trial is testing

Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

Who this might be right for
Breast CancerHER2-positive Breast CancerER Positive Breast Cancer+1 more
Ruth O'Regan 30
Testing effectiveness (Phase 2)Study completedNCT00777101
What this trial is testing

Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer

Who this might be right for
Advanced Breast CancerBreast Cancer
Puma Biotechnology, Inc. 233
Testing effectiveness (Phase 2)Study completedNCT01827267
What this trial is testing

Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Cancer

Who this might be right for
HER2-mutant Non-Small Cell Lung Cancer
Puma Biotechnology, Inc. 62
Early research (Phase 1)Study completedNCT00864487
What this trial is testing

Study Evaluating The Potential Effect Of Rifampin On The Pharmacokinetics Of Neratinib

Who this might be right for
Healthy Subjects
Puma Biotechnology, Inc. 24
Testing effectiveness (Phase 2)WithdrawnNCT04856475
What this trial is testing

Evaluation of Neratinib for Treatment and Prevention of Subsequent CNS Event(s) in Patients With Brain Metastasis of Advanced HER2 Positive Breast Cancer

Who this might be right for
Breast CancerBrain Metastases
Jules Bordet Institute
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07333937
What this trial is testing

Neratinib Combined With Fulvestrant and Eribulin in the Treatment ofHR+/HER2+ Advanced Breast Cancer

Who this might be right for
Brest Cancer
Xijing Hospital 35
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