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Results for “Neurofibroma, Plexiform”

78 trials

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Showing 20 of 78 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT05309668
What this trial is testing

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 36
Testing effectiveness (Phase 2)Study completedNCT01673009
What this trial is testing

Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis
Indiana University 36
Early research (Phase 1)Looking for participantsNCT02390752
What this trial is testing

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

Who this might be right for
Neurofibroma, PlexiformPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, Promyelocytic, Acute+1 more
National Cancer Institute (NCI) 54
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06763315
What this trial is testing

Low-dose Selumetinib for the Treatment of Plexiform Neurofibromas in Chinese Children

Who this might be right for
Plexiform Neurofibromas (PN)
West China Hospital 50
Not applicableStudy completedNCT04879160
What this trial is testing

Systematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement From Photographs of Subjects With Neurofibromatosis Type 1 on a Phase 2 Clinical Trial

Who this might be right for
Neurofibromatosis 1
National Cancer Institute (NCI) 52
Testing effectiveness (Phase 2)Ended earlyNCT00326872
What this trial is testing

AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine

Who this might be right for
Neurofibromatosis Type 1Plexiform NeurofibromaSpinal Cord Neurofibroma
National Cancer Institute (NCI) 26
Testing effectiveness (Phase 2)Study completedNCT00396019
What this trial is testing

Study of PEG-Intron for Plexiform Neurofibromas

Who this might be right for
Plexiform Neurofibroma
University of Pittsburgh 86
Testing effectiveness (Phase 2)WithdrawnNCT03109301
What this trial is testing

Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)

Who this might be right for
Neoplasms, Nerve TissueNeurofibromatosis 1Heredodegenerative Disorders, Nervous System+1 more
National Cancer Institute (NCI)
Early research (Phase 1)Active Not RecruitingNCT05101148
What this trial is testing

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 24
Testing effectiveness (Phase 2)Study completedNCT00076102
What this trial is testing

Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis 1Neurofibroma, Plexiform
National Cancer Institute (NCI) 36
Not applicableAvailableNCT05028166
What this trial is testing

Individual Patient Compassionate Use of Mirdametinib

Who this might be right for
Neurofibromatosis Type 1-Associated Plexiform NeurofibromasHistiocytic NeoplasmOther MAP-K Pathway Driven Diseases
SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Testing effectiveness (Phase 2)Study completedNCT03326388
What this trial is testing

Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours

Who this might be right for
Neurofibromatosis Type 1Plexiform NeurofibromaOptic Nerve Glioma
Great Ormond Street Hospital for Children NHS Foundation Trust 14
Testing effectiveness (Phase 2)Ended earlyNCT02177825
What this trial is testing

Study of Imatinib Mesylate in Neurofibromatosis Type I Patients Aged 2 to 21 With Plexiform Neurofibromas

Who this might be right for
Plexiform Neurofibromas
St. Justine's Hospital 5
Not applicableApproved For MarketingNCT03259633
What this trial is testing

An Intermediate Access Protocol for Selumetinib for Treatment of Neurofibromatosis Type 1

Who this might be right for
NF type1 With Inoperable Plexiform Neurofibromas
AstraZeneca
Testing effectiveness (Phase 2)WithdrawnNCT05825365
What this trial is testing

Selumetinib in Chinese Paediatric With Post-operative NF1-PNs, PhaseⅡ, Double-Blinded, Placebo-Controlled Study

Who this might be right for
Neurofibromatosis Type 1Plexiform NeurofibromasPost-operative
AstraZeneca
Large-scale testing (Phase 3)Study completedNCT02180867
What this trial is testing

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

Who this might be right for
Alveolar Soft Part SarcomaAngiomatoid Fibrous HistiocytomaAtypical Fibroxanthoma+33 more
National Cancer Institute (NCI) 140
Not applicableStudy completedNCT00006435
What this trial is testing

Study of Plexiform Neurofibromas in Neurofibromatosis Type 1

Who this might be right for
Plexiform NeurofibromasNF1
National Cancer Institute (NCI) 24
Early research (Phase 1)Active Not RecruitingNCT06104488
What this trial is testing

Avutometinib for People With Solid Tumor Cancers

Who this might be right for
Refractory CancerCNS TumorsCNS Tumor, Adult+12 more
Memorial Sloan Kettering Cancer Center 3
Early research (Phase 1)Active Not RecruitingNCT04590235
What this trial is testing

Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

Who this might be right for
Neurofibromatosis 1Neurofibroma Plexiform
AstraZeneca 32
Large-scale testing (Phase 3)Looking for participantsNCT07407803
What this trial is testing

Evaluation of TQ-B3234 Capsules in Patients With Symptomatic, Non-Surgical Type 1 Neurofibromatosis-Associated Plexiform Neurofibromas

Who this might be right for
Plexiform Neurofibroma
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 177
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