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Results for “Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PNs)”

10 trials

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Showing 10 of 10 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT03741101
What this trial is testing

Treatment of NF1-related Plexiform Neurofibroma With Trametinib

Who this might be right for
Neurofibromatosis 1ChildNeurofibroma, Plexiform
Region Skane 15
Early research (Phase 1)Study completedNCT03649165
What this trial is testing

Evaluate Bioavailability and Food Effect of Selumetinib (AZD6244) in Healthy Male Participants

Who this might be right for
Neurofibromatosis Type 1 (NF1)-Related Plexiform Neurofibromas (PNs)Healthy Participants
AstraZeneca 24
Not applicableStudy completedNCT04879160
What this trial is testing

Systematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement From Photographs of Subjects With Neurofibromatosis Type 1 on a Phase 2 Clinical Trial

Who this might be right for
Neurofibromatosis 1
National Cancer Institute (NCI) 52
Early research (Phase 1)Looking for participantsNCT06961565
What this trial is testing

PAS-004 in Adults Who Have Neurofibromatosis Type 1 With Plexiform Neurofibromas

Who this might be right for
NF1 MutationNeurofibroma PlexiformNeurofibroma, Plexiform+2 more
Pasithea Therapeutics Corp. 56
Testing effectiveness (Phase 2)Active Not RecruitingNCT05309668
What this trial is testing

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 36
Early research (Phase 1)Active Not RecruitingNCT05101148
What this trial is testing

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 24
Testing effectiveness (Phase 2)Study completedNCT00634270
What this trial is testing

A Phase II Study of the mTOR Inhibitor Sirolimus in Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1
University of Alabama at Birmingham 58
Testing effectiveness (Phase 2)Study completedNCT01412892
What this trial is testing

Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1Plexiform NeurofibromaNeurofibromatoses
Assistance Publique - Hôpitaux de Paris 30
Large-scale testing (Phase 3)Active Not RecruitingNCT05913037
What this trial is testing

FCN-159 in Adult Patients With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis 1Plexiform NeurofibromaNF1
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. 167
Not applicableLooking for participantsNCT06222203
What this trial is testing

Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

Who this might be right for
Neurofibromatosis 1Nerve Sheath Neoplasms
National Cancer Institute (NCI) 225