Not applicableStudy completedNCT06482164What this trial is testingThe THINK Study Incidence of Neurotrophic Keratopathy)Who this might be right forDry Eye Research Insight LLC 31
Post-approval studies (Phase 4)UnknownNCT06331910What this trial is testingEfficacy and Safety of Topical Insulin for Neurotrophic Corneal UlcersWho this might be right forNeurotrophic Keratopathy Assiut University 14
Not applicableStudy completedNCT04293549What this trial is testingAn 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) EyedropsWho this might be right forNeurotrophic Keratopathy G. d'Annunzio University 18
Large-scale testing (Phase 3)WithdrawnNCT05321251What this trial is testingTopical Insulin Drops for the Treatment of Neurotrophic Keratopathy.Who this might be right forNeurotrophic Keratitis University of Alberta
Not applicableTemporarily pausedNCT05758753What this trial is testingQST for Corneal Nerve FunctionWho this might be right forCorneal DiseaseNeuropathyDry Eye Disease+1 more Tufts Medical Center 108
Testing effectiveness (Phase 2)Study completedNCT01756456What this trial is testingEvaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis.Who this might be right forNeurotrophic KeratitisKeratitisCorneal Ulcer Dompé Farmaceutici S.p.A 174
Not applicableLooking for participantsNCT04604834What this trial is testingAutologous Platelet-rich Plasma (APRP) in the Treatment of Neurotrophic KeratopathyWho this might be right forNeurotrophic Keratopathy Universidad Autonoma de Nuevo Leon 39
Testing effectiveness (Phase 2)Looking for participantsNCT06919081What this trial is testingEfficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface DiseaseWho this might be right forPersistent Corneal Epithelial DefectCorneal Epithelial Disorders University of Illinois at Chicago 24
Testing effectiveness (Phase 2)Study completedNCT02227147What this trial is testingEvaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NKWho this might be right forNeurotrophic Keratitis Dompé Farmaceutici S.p.A 48
Not applicableUnknownNCT06412718What this trial is testingValidation of Human Drugs Target of Repurposed Drugs and Novel TherapiesWho this might be right forRare DiseasesAniridiaNeurotrophic Keratopathy+5 more IRCCS Ospedale San Raffaele 274
Not applicableNot Yet RecruitingNCT07694817What this trial is testingClinical Predictors of Visual Outcome in Patients Affected With Ocular Surface DiseasesWho this might be right forNeurotrophic KeratopathyExposure KeratopathyLimbal Stem Cell Deficiency (LSCD)+3 more IRCCS San Raffaele 1,000
Large-scale testing (Phase 3)Ended earlyNCT02600429What this trial is testingAssessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1Who this might be right forNeurotrophic Keratopathy ReGenTree, LLC 18
Not applicableUnknownNCT04573647What this trial is testingOCT Evaluation of Neurotrophic Ulcer Following Treatment With OxervateWho this might be right forNeurotrophic UlcerNeurotrophic KeratitisNeurotrophic Corneal Ulcer+1 more Sight Medical Doctors PLLC 10
Testing effectiveness (Phase 2)Study completedNCT07120308What this trial is testingTo Evaluate the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects Caused by Neurotrophic KeratitisWho this might be right forCorneal Epithelial Defect Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd. 28
Not applicableStudy completedNCT04820010What this trial is testingTopical Insulin - Utility and Results in Neurotrophic Keratopathy in Stages 2 and 3Who this might be right forCorneal UlcerCorneal PerforationCorneal Epithelium Defect+1 more Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E. 20
Testing effectiveness (Phase 2)Study completedNCT04276558What this trial is testingREC 0/0559 Eye Drops for Treatment of Moderate and Severe Neurotrophic Keratitis in Adult PatientsWho this might be right forNeurotrophic Keratitis RECORDATI GROUP 108
Not applicableStudy completedNCT04552730What this trial is testingNerve Growth Factor for the Treatment of Cornea DiseaseWho this might be right forNeurotrophic Keratitis Stanford University 5
Not applicableEnded earlyNCT05809245What this trial is testingCorneal Neurotization as a Treatment for Neurotrophic KeratopathyWho this might be right forNeurotrophic Corneal UlcerNeurotrophic KeratitisCranial Nerve V Diseases Stanford University 4
Testing effectiveness (Phase 2)Study completedNCT02592330What this trial is testingLimbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) GraftWho this might be right forLimbal Stem Cell Deficiency Massachusetts Eye and Ear Infirmary 23
Testing effectiveness (Phase 2)Looking for participantsNCT05927428What this trial is testingAssessment of the Initial Efficacy and Safety of BRM424 Ophthalmic Solutions in Patients With Neurotrophic KeratitisWho this might be right forNeurotrophic Keratitis BRIM Biotechnology Inc. 12