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Results for “Non-Small Cell Lung Cancer With HER2- Mutations”

58 trials

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Showing 20 of 58 results

Testing effectiveness (Phase 2)Looking for participantsNCT07486817
What this trial is testing

Beamion 44: A Study to Test How Well Zongertinib is Tolerated by People With Advanced Non-small Cell Lung Cancer With HER2 Mutations When Given in Combination With Chemotherapy With or Without Pembrolizumab

Who this might be right for
Lung Cancer, Non-squamous, Non-small Cell
Boehringer Ingelheim 60
Testing effectiveness (Phase 2)Study completedNCT01827267
What this trial is testing

Neratinib With and Without Temsirolimus for Patients With HER2 Activating Mutations in Non-Small Cell Lung Cancer

Who this might be right for
HER2-mutant Non-Small Cell Lung Cancer
Puma Biotechnology, Inc. 62
Large-scale testing (Phase 3)Looking for participantsNCT06430437
What this trial is testing

SHR-A1811 in First-line Treatment of Patients With Advanced or Metastatic Non-small Cell Lung Cancer With HER2 Mutations

Who this might be right for
Non-Small Cell Lung Cancer With HER2- Mutations
Jiangsu HengRui Medicine Co., Ltd. 300
Not applicableLooking for participantsNCT06809764
What this trial is testing

Clinical Effectiveness and Safety of Trastuzumab Deruxtecan (T-DXd) in Chinese Patients With HER2m NSCLC (RERUN)

Who this might be right for
Non-small Cell Lung Cancer
Daiichi Sankyo 150
Testing effectiveness (Phase 2)UnknownNCT05068024
What this trial is testing

FWD1509 in Adults With Non-Small Cell Lung Cancer

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Forward Pharmaceuticals Co., Ltd. 30
Large-scale testing (Phase 3)Active Not RecruitingNCT05048797
What this trial is testing

Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations

Who this might be right for
Locally Advanced or Metastatic Non-Small Cell Lung Cancer
AstraZeneca 454
Early research (Phase 1)Not Yet RecruitingNCT07436858
What this trial is testing

Whole Body HER2 Quantification With 89Zr-Trastuzumab PET/CT to Asses Zr-trastuzumab Accumulation in HER2-mutated and HER2-overexpressing Metastatic Non-small Cell Lung Cancer

Who this might be right for
Lung Cancer (NSCLC)HER2 ExpressionHER2 Gene Mutation
The Netherlands Cancer Institute 20
Large-scale testing (Phase 3)Looking for participantsNCT06452277
What this trial is testing

Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Who this might be right for
Advanced Non-small Cell Lung Cancer, HER2 Mutation
Bayer 555
Testing effectiveness (Phase 2)Study completedNCT04311034
What this trial is testing

RC48-ADC in Subjects With Advanced Non-small Cell Lung Cancer

Who this might be right for
Non Small Cell Lung Cancer
RemeGen Co., Ltd. 37
Large-scale testing (Phase 3)Temporarily pausedNCT05378763
What this trial is testing

Poziotinib in Previously Treated Participants With Locally Advanced or Metastatic NSCLC Harboring HER2 Exon 20 Mutations

Who this might be right for
NSCLC
Spectrum Pharmaceuticals, Inc 268
Testing effectiveness (Phase 2)Looking for participantsNCT04144569
What this trial is testing

PD-1 Combined With Pyrotinib for Chemotherapy Failure HER2 Insertion Mutation Advanced NSCLC

Who this might be right for
HER2 Insertion Mutation Positive Advanced NSCLC
Yongchang Zhang 30
Early research (Phase 1)Study completedNCT02442414
What this trial is testing

KBP-5209 in Patients With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumors
Sihuan Pharmaceutical Holdings Group Ltd. 35
Testing effectiveness (Phase 2)Looking for participantsNCT06706076
What this trial is testing

BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

Who this might be right for
NSCLC (Advanced Non-small Cell Lung Cancer)
BlossomHill Therapeutics 675
Testing effectiveness (Phase 2)UnknownNCT06519110
What this trial is testing

Neratinib Tablets Monotherapy for Advanced Solid Tumors With HER2 Mutations

Who this might be right for
Advanced Solid Tumor
Convalife (Shanghai) Co., Ltd. 60
Testing effectiveness (Phase 2)Study completedNCT01542437
What this trial is testing

Treatment With BIBW 2992, Irreversible Inhibitor of EGFR and HER-2 in Non-small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung CancerEGFRHER-2
Instituto Nacional de Cancerologia de Mexico 66
Testing effectiveness (Phase 2)Looking for participantsNCT06043817
What this trial is testing

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

Who this might be right for
Non-Small Cell Lung CancerNSCLCEGFR/HER2 Exon 20 Insertion Mutation
Pierre Fabre Medicament 345
Testing effectiveness (Phase 2)Study completedNCT02597946
What this trial is testing

Afatinib in NSCLC With HER2 Mutation

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim 18
Testing effectiveness (Phase 2)Ended earlyNCT01953926
What this trial is testing

Basket Study of Neratinib in Participants With Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations

Who this might be right for
Solid Tumors Harboring Somatic HER2 or EGFR Exon 18 Mutations
Puma Biotechnology, Inc. 582
Not applicableStudy completedNCT01700582
What this trial is testing

French National Observatory of the Patients With Non-small Cell Lung (NSCLC) and Molecular Testings

Who this might be right for
Carcinoma, Non-Small-Cell LungALK Gene MutationKRAS Gene Mutation+1 more
Intergroupe Francophone de Cancerologie Thoracique 17,664
Early research (Phase 1)Looking for participantsNCT06625775
What this trial is testing

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

Who this might be right for
Solid Tumor, AdultMetastatic Breast CancerAdvanced Breast Cancer+8 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) 392
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