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Results for “Non-transfusion Dependent Thalassemia”

33 trials

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Showing 20 of 33 results

Testing effectiveness (Phase 2)Ended earlyNCT04059406
What this trial is testing

Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Sapablursen (Formerly ISIS 702843, IONIS-TMPRSS6-LRx)

Who this might be right for
Beta Thalassemia Intermedia
Ionis Pharmaceuticals, Inc. 29
Large-scale testing (Phase 3)Study completedNCT00176852
What this trial is testing

Stem Cell Transplant for Hemoglobinopathy

Who this might be right for
Sickle Cell DiseaseThalassemiaSevere Congenital Neutropenia+2 more
Masonic Cancer Center, University of Minnesota 22
Testing effectiveness (Phase 2)Study completedNCT04987489
What this trial is testing

Etavopivat in Patients With Thalassemia or Sickle Cell Disease

Who this might be right for
Sickle Cell DiseaseThalassemia
Forma Therapeutics, Inc. 53
Not applicableEnded earlyNCT02179359
What this trial is testing

Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

Who this might be right for
Sickle Cell DiseaseTransfusion Dependent Alpha- or Beta- ThalassemiaDiamond Blackfan Anemia+5 more
Masonic Cancer Center, University of Minnesota 38
Large-scale testing (Phase 3)Study completedNCT07210450
What this trial is testing

Effect of L-Glutamine on Pulmonary Artery Pressure in Patients With Non-Transfusion-Dependent Thalassemia

Who this might be right for
Pulmonary Artery PressureThalassemiaNon-transfusion Dependent Thalassemia
Mazandaran University of Medical Sciences 8
Testing effectiveness (Phase 2)Active Not RecruitingNCT06421636
What this trial is testing

Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body

Who this might be right for
Non-Transfusion Dependent Beta-Thalassemia (NTDT)
Regeneron Pharmaceuticals 19
Testing effectiveness (Phase 2)Study completedNCT04364269
What this trial is testing

Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD) and Preliminary Efficacy of VIT-2763 in β-thalassaemia

Who this might be right for
Beta-ThalassemiaNon-transfusion-dependent Thalassemia
Vifor (International) Inc. 35
Testing effectiveness (Phase 2)Active Not RecruitingNCT05664737
What this trial is testing

Determine the Efficacy and Safety of Luspatercept in Adult Participants and to Evaluate the Safety and Pharmacokinetics in and Adolescent Participants With Alpha (α)-Thalassemia

Who this might be right for
Anemia
Bristol-Myers Squibb 189
Testing effectiveness (Phase 2)Study completedNCT03271541
What this trial is testing

Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia

Who this might be right for
Beta-Thalassemia
Hoffmann-La Roche 12
Not applicableStudy completedNCT02626689
What this trial is testing

To Document the Burden of Illness on the Quality of Life and the Impact on Healthcare Utilization in (Beta) β-thalassemia Subjects Who Are Transfusion Dependent (TD) and Non-transfusion Dependent (NTD) Receiving Standard of Care

Who this might be right for
Beta-Thalassemia
Celgene 100
Large-scale testing (Phase 3)Study completedNCT01033747
What this trial is testing

Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension Study

Who this might be right for
Liver Iron Overload
Novartis Pharmaceuticals 70
Testing effectiveness (Phase 2)Enrolling By InvitationNCT04432623
What this trial is testing

The BENeFiTS Trial in Beta Thalassemia Intermedia

Who this might be right for
Beta Thalassemia IntermediaSickle Cell Disease
Phoenicia BioScience 36
Early research (Phase 1)Looking for participantsNCT06772766
What this trial is testing

A Multiple Ascending Dose Study of 9MW3011 in Patients With Non-transfusion-dependent β-thalassemia

Who this might be right for
Beta-Thalassemia
Mabwell (Shanghai) Bioscience Co., Ltd. 40
Early research (Phase 1)WithdrawnNCT04176653
What this trial is testing

Study in Beta-thalassaemia or Myelodysplastic Syndrome Patients to Investigate the Safety and Tolerability of SLN124

Who this might be right for
Non-transfusion-dependent ThalassemiaLow Risk Myelodysplastic Syndrome
Silence Therapeutics plc
Testing effectiveness (Phase 2)Study completedNCT03802201
What this trial is testing

Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia

Who this might be right for
β-thalassemiaIneffective ErythropoiesisChronic Anemia
Protagonist Therapeutics, Inc. 63
Large-scale testing (Phase 3)Looking for participantsNCT07517133
What this trial is testing

Investigate the Efficacy, Pharmacokinetics, and Safety of Mitapivat in Pediatric Participants With α- or β-Non-Transfusion-Dependent Thalassemia

Who this might be right for
Non-Transfusion-dependent Alpha-ThalassemiaNon-Transfusion-dependent Beta-Thalassemia
Agios Pharmaceuticals, Inc. 45
Post-approval studies (Phase 4)Study completedNCT01709838
What this trial is testing

Efficacy and Safety Study of Deferasirox in Patients With Non-transfusion Dependent Thalassemia

Who this might be right for
Non-transfusion Dependent Thalassemia
Novartis Pharmaceuticals 134
Testing effectiveness (Phase 2)Active Not RecruitingNCT03692052
What this trial is testing

Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AG-348 in Adult Participants With Non-transfusion-dependent Thalassemia

Who this might be right for
Thalassemia
Agios Pharmaceuticals, Inc. 20
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07579949
What this trial is testing

SNH-119014 in Adult Participants With Non-transfusion-dependent Thalassemia (NTDT)

Who this might be right for
Thalassemia
ScinnoHub Pharmaceutical Co., Ltd. 30
Testing effectiveness (Phase 2)Study completedNCT00873041
What this trial is testing

Efficacy and Safety of Deferasirox in Non-transfusion Dependent Thalassemia Patients With Iron Overload and a One Year Open-label Extension Study

Who this might be right for
Non-transfusion Dependent Thalassemia
Novartis Pharmaceuticals 166
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