Not applicableEnded earlyNCT05250570What this trial is testingDistress Tolerance for Benzodiazepine DiscontinuationWho this might be right forSubstance Use Disorders University of Pittsburgh 1
Not applicableStudy completedNCT00669175What this trial is testingSafety and Efficacy of a Low Dose Naloxone Infusion in NICU PatientsWho this might be right forOpioid TolerancePain Children's Mercy Hospital Kansas City 25
Large-scale testing (Phase 3)Study completedNCT00737997What this trial is testingEffect of Early Morphine Administration on the Development of Acute Opioid Tolerance During Pediatric Scoliosis SurgeryWho this might be right forScoliosis The Hospital for Sick Children 40
Post-approval studies (Phase 4)Study completedNCT01325493What this trial is testingLow Dose Ketamine Study on Opioid Tolerance and HyperalgesiaWho this might be right forIdiopathic ScoliosisSpondylolisthesis Julia Finkel 54
Large-scale testing (Phase 3)Study completedNCT00286052What this trial is testingImpact of Low Dose Naloxone on Fentanyl Requirements in Pediatric ICU PatientsWho this might be right forOpioid Tolerance University of Texas Southwestern Medical Center 128
Not applicableStudy completedNCT03934411What this trial is testingEffect of Increased Pain Tolerance on Exercise PerformanceWho this might be right forOpioid UseExercise University of Copenhagen 16
Early research (Phase 1)Study completedNCT03879460What this trial is testingThe Evaluation of Safety and Tolerance of Commercially Available Naltrexone Administered Daily - Assessment for CBRN OperationsWho this might be right forOpioid Intoxication Timothy Smith 15
Early research (Phase 1)Ended earlyNCT00618397What this trial is testingPharmacokinetics of Low Dose Ketamine InfusionWho this might be right forSedationOpioid Tolerance University of Texas Southwestern Medical Center 5
Large-scale testing (Phase 3)UnknownNCT01718496What this trial is testingMorphine, Dyspnea, Exercise and COPDWho this might be right forChronic Obstructive Pulmonary Disease McGill University Health Centre/Research Institute of the McGill University Health Centre 20
Testing effectiveness (Phase 2)UnknownNCT03824834What this trial is testingMorphine to Maximize the Benefits of Exercise Training in COPD or ILD and Persistent BreathlessnessWho this might be right forChronic Obstructive Pulmonary DiseaseInterstitial Lung Disease Dennis Jensen, Ph.D. 40
Testing effectiveness (Phase 2)Study completedNCT00000255What this trial is testingDifferential Acute Tolerance Development to Effects of Nitrous Oxide - 7Who this might be right forOpioid-Related DisordersSubstance-Related Disorders University of Chicago 10
Testing effectiveness (Phase 2)Study completedNCT00522587What this trial is testingSevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid ToleranceWho this might be right forAnesthesia University Hospital, Ghent 40
Large-scale testing (Phase 3)Study completedNCT01556087What this trial is testingDistress Tolerance and BuprenorphineWho this might be right forOpioid Dependence Butler Hospital 59
Post-approval studies (Phase 4)Study completedNCT00246532What this trial is testingOpiate-Induced Tolerance & Hyperalgesia in Pain PatientsWho this might be right forChronic Low Back PainOpioid-induced Hyperalgesia National Institute of General Medical Sciences (NIGMS) 139
Not applicableEnded earlyNCT03294174What this trial is testingOpioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee ArthroplastyWho this might be right forOpioid Tolerance, Opioid Naive, Opioid Exposure University of Pittsburgh 48
Testing effectiveness (Phase 2)Study completedNCT00210158What this trial is testingIntraoperative Nitrous Oxide and Postoperative Pain for Patients With Current Opioid TreatmentWho this might be right forChronic Pain Institut Bergonié 39
Not applicableUnknownNCT05276258What this trial is testingCryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant PatientsWho this might be right forPainPain, Postoperative The Methodist Hospital Research Institute 75
Testing effectiveness (Phase 2)Study completedNCT00000252What this trial is testingLack of Acute Tolerance Development to Effects of Nitrous Oxide - 4Who this might be right forOpioid-Related DisordersSubstance-Related Disorders University of Chicago 11
Not applicableStudy completedNCT02602795What this trial is testingDistress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid DependenceWho this might be right forOpiate DependenceSexually Transmitted DiseasesHIV Rhode Island Hospital 14
Testing effectiveness (Phase 2)Study completedNCT00000352What this trial is testingEffects of Dextromethorphan on Opioid Tolerance in Methadone Patients - 1Who this might be right forOpioid-Related DisordersSubstance-Related Disorders National Institute on Drug Abuse (NIDA)