Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Orexin Antagonist”

23 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 23 results

Post-approval studies (Phase 4)Study completedNCT04092894
What this trial is testing

Suvorexant and Sleep/Delirium in ICU Patients

Who this might be right for
InsomniaSleep FragmentationSleep Initiation and Maintenance Disorders+1 more
Beth Israel Deaconess Medical Center 100
Testing effectiveness (Phase 2)Looking for participantsNCT06854224
What this trial is testing

Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial

Who this might be right for
Suicide RiskMajor Depressive Disorder (MDD)
Marianne Goodman 30
Testing effectiveness (Phase 2)Looking for participantsNCT06274528
What this trial is testing

DORA and LP in Alzheimer's Disease Biomarkers

Who this might be right for
Alzheimer Disease
University of Minnesota 201
Not applicableStudy completedNCT06311864
What this trial is testing

Real-World Observational Study on Patient-Reported Outcomes in the Treatment of Insomnia With Daridorexant in Canada

Who this might be right for
Insomnia
PeriPharm 90
Post-approval studies (Phase 4)Looking for participantsNCT03642028
What this trial is testing

Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

Who this might be right for
Sleep Initiation and Maintenance DisordersStress Disorders, Posttraumatic
VA Office of Research and Development 190
Large-scale testing (Phase 3)Study completedNCT00608985
What this trial is testing

Almorexant (ACT 078573) in Adult Subjects With Chronic Primary Insomnia

Who this might be right for
Primary Insomnia
Midnight Pharma, LLC 709
Post-approval studies (Phase 4)Not Yet RecruitingNCT07407400
What this trial is testing

Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients

Who this might be right for
Sleep DisturbanceDeliriumCritical Illness
Mahidol University 100
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06648681
What this trial is testing

Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients

Who this might be right for
Delirium - PostoperativeCardiac SurgeryCardiac Surgery Subjects+4 more
University of British Columbia 60
Testing effectiveness (Phase 2)UnknownNCT03755310
What this trial is testing

Treatment of Restless Legs Syndrome With the Hypocretin Antagonist Suvorexant

Who this might be right for
Restless Legs Syndrome
Diego García-Borreguero, MD, PhD 43
Post-approval studies (Phase 4)Not Yet RecruitingNCT07830303
What this trial is testing

Daridorexant for Sleep Disturbance in Adults With Liver Cirrhosis

Who this might be right for
Liver CirrhosisSleep DisturbanceHepatic Encephalopathy
Wang Fengmei 180
Early research (Phase 1)Study completedNCT01954589
What this trial is testing

Single-ascending Dose Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-462206

Who this might be right for
SafetyTolerabilityPharmacodynamics+1 more
Idorsia Pharmaceuticals Ltd. 56
Post-approval studies (Phase 4)Study completedNCT06584942
What this trial is testing

Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)

Who this might be right for
Cue-reactivityCannabis Use DisorderFunctional MRI+1 more
Massachusetts General Hospital 20
Testing effectiveness (Phase 2)Looking for participantsNCT07213349
What this trial is testing

Daridorexant for Alzheimer Disease Prevention

Who this might be right for
Alzheimer Disease (AD)
Douglas Mental Health University Institute 240
Testing effectiveness (Phase 2)Study completedNCT05546515
What this trial is testing

Suvorexant for Opioid/Stimulant Co-use

Who this might be right for
Opioid Use DisorderStimulant Use Disorder
Johns Hopkins University 20
Post-approval studies (Phase 4)Study completedNCT05344443
What this trial is testing

Lemborexant Shift Work Treatment Study

Who this might be right for
Shift-Work Related Sleep Disturbance
University of California, San Francisco 29
Early research (Phase 1)Study completedNCT01300455
What this trial is testing

Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)

Who this might be right for
Sleep Apnea
Merck Sharp & Dohme LLC 26
Testing effectiveness (Phase 2)Looking for participantsNCT06823752
What this trial is testing

A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.

Who this might be right for
Insomnia
Woolcock Institute of Medical Research 20
Post-approval studies (Phase 4)WithdrawnNCT06834386
What this trial is testing

Suvorexant for Insomnia to Prevent Delirium in Hospitalized Cancer Patients

Who this might be right for
Advanced Malignant Solid NeoplasmDeliriumHematopoietic and Lymphatic System Neoplasm+1 more
Mayo Clinic
Not applicableStudy completedNCT01243060
What this trial is testing

Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance

Who this might be right for
Healthy Volunteers
Northern California Institute of Research and Education 203
Not applicableLooking for participantsNCT07417813
What this trial is testing

Observational Study of Lemborexant on Insomnia Patients With Psychiatric Disorders

Who this might be right for
InsomniaPsychiatric Disorders
Shanghai Mental Health Center 121
Next Page