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Results for “Orexin Antagonist”

22 trials

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Showing 20 of 22 results

Not applicableLooking for participantsNCT07417813
What this trial is testing

Observational Study of Lemborexant on Insomnia Patients With Psychiatric Disorders

Who this might be right for
InsomniaPsychiatric Disorders
Shanghai Mental Health Center 121
Post-approval studies (Phase 4)Looking for participantsNCT03642028
What this trial is testing

Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress

Who this might be right for
Sleep Initiation and Maintenance DisordersStress Disorders, Posttraumatic
VA Office of Research and Development 190
Testing effectiveness (Phase 2)UnknownNCT03755310
What this trial is testing

Treatment of Restless Legs Syndrome With the Hypocretin Antagonist Suvorexant

Who this might be right for
Restless Legs Syndrome
Diego García-Borreguero, MD, PhD 43
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06648681
What this trial is testing

Lemborexant to Prevent Post-operative Delirium in Cardiac Surgery Patients

Who this might be right for
Delirium - PostoperativeCardiac SurgeryCardiac Surgery Subjects+4 more
University of British Columbia 60
Testing effectiveness (Phase 2)Looking for participantsNCT06854224
What this trial is testing

Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial

Who this might be right for
Suicide RiskMajor Depressive Disorder (MDD)
Marianne Goodman 30
Not applicableStudy completedNCT06311864
What this trial is testing

Real-World Observational Study on Patient-Reported Outcomes in the Treatment of Insomnia With Daridorexant in Canada

Who this might be right for
Insomnia
PeriPharm 90
Large-scale testing (Phase 3)Study completedNCT00608985
What this trial is testing

Almorexant (ACT 078573) in Adult Subjects With Chronic Primary Insomnia

Who this might be right for
Primary Insomnia
Midnight Pharma, LLC 709
Testing effectiveness (Phase 2)Looking for participantsNCT06823752
What this trial is testing

A Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.

Who this might be right for
Insomnia
Woolcock Institute of Medical Research 20
Post-approval studies (Phase 4)WithdrawnNCT06834386
What this trial is testing

Suvorexant for Insomnia to Prevent Delirium in Hospitalized Cancer Patients

Who this might be right for
Advanced Malignant Solid NeoplasmDeliriumHematopoietic and Lymphatic System Neoplasm+1 more
Mayo Clinic
Early research (Phase 1)Study completedNCT01300455
What this trial is testing

Effects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)

Who this might be right for
Sleep Apnea
Merck Sharp & Dohme LLC 26
Testing effectiveness (Phase 2)Looking for participantsNCT07213349
What this trial is testing

Daridorexant for Alzheimer Disease Prevention

Who this might be right for
Alzheimer Disease (AD)
Douglas Mental Health University Institute 240
Not applicableStudy completedNCT01243060
What this trial is testing

Effect of a Hypocretin/Orexin Antagonist on Neurocognitive Performance

Who this might be right for
Healthy Volunteers
Northern California Institute of Research and Education 203
Post-approval studies (Phase 4)Study completedNCT04092894
What this trial is testing

Suvorexant and Sleep/Delirium in ICU Patients

Who this might be right for
InsomniaSleep FragmentationSleep Initiation and Maintenance Disorders+1 more
Beth Israel Deaconess Medical Center 100
Testing effectiveness (Phase 2)Study completedNCT05546515
What this trial is testing

Suvorexant for Opioid/Stimulant Co-use

Who this might be right for
Opioid Use DisorderStimulant Use Disorder
Johns Hopkins University 20
Post-approval studies (Phase 4)Study completedNCT05344443
What this trial is testing

Lemborexant Shift Work Treatment Study

Who this might be right for
Shift-Work Related Sleep Disturbance
University of California, San Francisco 29
Early research (Phase 1)Study completedNCT01954589
What this trial is testing

Single-ascending Dose Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-462206

Who this might be right for
SafetyTolerabilityPharmacodynamics+1 more
Idorsia Pharmaceuticals Ltd. 56
Testing effectiveness (Phase 2)Looking for participantsNCT06981195
What this trial is testing

Effects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder Subjects

Who this might be right for
Opioid Use DisorderOpioid UseInsomnia+1 more
Virginia Commonwealth University 100
Post-approval studies (Phase 4)Not Yet RecruitingNCT07407400
What this trial is testing

Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients

Who this might be right for
Sleep DisturbanceDeliriumCritical Illness
Mahidol University 100
Testing effectiveness (Phase 2)Study completedNCT02832336
What this trial is testing

The Effect of Caffeine on the Narcoleptic Patients

Who this might be right for
Narcolepsy
King Saud University 16
Post-approval studies (Phase 4)Looking for participantsNCT06584942
What this trial is testing

Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)

Who this might be right for
Cue-reactivityCannabis Use DisorderFunctional MRI+1 more
Massachusetts General Hospital 20
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