Testing effectiveness (Phase 2)Study completedNCT05546515What this trial is testingSuvorexant for Opioid/Stimulant Co-useWho this might be right forOpioid Use DisorderStimulant Use Disorder Johns Hopkins University 20
Testing effectiveness (Phase 2)Looking for participantsNCT06823752What this trial is testingA Dual Orexin Receptor Antagonist to Reduce Biomarkers of Neurodegeneration in Adults With Insomnia.Who this might be right forInsomnia Woolcock Institute of Medical Research 20
Not applicableEnrolling By InvitationNCT06311864What this trial is testingReal-World Observational Study on Patient-Reported Outcomes in the Treatment of Insomnia with Daridorexant in CanadaWho this might be right forInsomnia PeriPharm 100
Not applicableStudy completedNCT01243060What this trial is testingEffect of a Hypocretin/Orexin Antagonist on Neurocognitive PerformanceWho this might be right forHealthy Volunteers Northern California Institute of Research and Education 203
Testing effectiveness (Phase 2)Study completedNCT02832336What this trial is testingThe Effect of Caffeine on the Narcoleptic PatientsWho this might be right forNarcolepsy King Saud University 16
Post-approval studies (Phase 4)WithdrawnNCT06834386What this trial is testingSuvorexant for Insomnia to Prevent Delirium in Hospitalized Cancer PatientsWho this might be right forAdvanced Malignant Solid NeoplasmDeliriumHematopoietic and Lymphatic System Neoplasm+1 more Mayo Clinic
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06648681What this trial is testingLemborexant to Prevent Post-operative Delirium in Cardiac Surgery PatientsWho this might be right forDelirium - PostoperativeCardiac SurgeryCardiac Surgery Subjects+4 more University of British Columbia 60
Early research (Phase 1)Study completedNCT01954589What this trial is testingSingle-ascending Dose Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-462206Who this might be right forSafetyTolerabilityPharmacodynamics+1 more Idorsia Pharmaceuticals Ltd. 56
Post-approval studies (Phase 4)Looking for participantsNCT07384429What this trial is testingEffects of Lemborexant on Motor-sleep Comorbidity in Parkinson's DiseaseWho this might be right forParkinson's DiseaseInsomniaMotor Disorder YangPan 44
Post-approval studies (Phase 4)Study completedNCT04092894What this trial is testingSuvorexant and Sleep/Delirium in ICU PatientsWho this might be right forInsomniaSleep FragmentationSleep Initiation and Maintenance Disorders+1 more Beth Israel Deaconess Medical Center 100
Testing effectiveness (Phase 2)Looking for participantsNCT06981195What this trial is testingEffects of Lemborexant on Insomnia and Its Relationship to Mood and Behavior on Opioid Use Disorder SubjectsWho this might be right forOpioid Use DisorderOpioid UseInsomnia+1 more Virginia Commonwealth University 100
Testing effectiveness (Phase 2)Looking for participantsNCT06274528What this trial is testingDORA and LP in Alzheimer's Disease BiomarkersWho this might be right forAlzheimer Disease Washington University School of Medicine 201
Testing effectiveness (Phase 2)Looking for participantsNCT07213349What this trial is testingDaridorexant for Alzheimer Disease PreventionWho this might be right forAlzheimer Disease (AD) Douglas Mental Health University Institute 240
Post-approval studies (Phase 4)Not Yet RecruitingNCT07407400What this trial is testingLemborexant for Sleep and Delirium Prevention in Elderly ICU PatientsWho this might be right forSleep DisturbanceDeliriumCritical Illness Mahidol University 100
Early research (Phase 1)Study completedNCT01300455What this trial is testingEffects of Suvorexant in Participants With Obstructive Sleep Apnea (MK-4305-036)Who this might be right forSleep Apnea Merck Sharp & Dohme LLC 26
Testing effectiveness (Phase 2)UnknownNCT03755310What this trial is testingTreatment of Restless Legs Syndrome With the Hypocretin Antagonist SuvorexantWho this might be right forRestless Legs Syndrome Diego García-Borreguero, MD, PhD 43
Post-approval studies (Phase 4)Looking for participantsNCT03642028What this trial is testingSuvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic StressWho this might be right forSleep Initiation and Maintenance DisordersStress Disorders, Posttraumatic VA Office of Research and Development 190
Post-approval studies (Phase 4)Study completedNCT05344443What this trial is testingLemborexant Shift Work Treatment StudyWho this might be right forShift-Work Related Sleep Disturbance University of California, San Francisco 29
Post-approval studies (Phase 4)Looking for participantsNCT06584942What this trial is testingEvaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)Who this might be right forCue-reactivityCannabis Use DisorderFunctional MRI+1 more Massachusetts General Hospital 20
Testing effectiveness (Phase 2)Looking for participantsNCT06854224What this trial is testingOrexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical TrialWho this might be right forSuicide RiskMajor Depressive Disorder (MDD) Marianne Goodman 30