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Results for “PCSK9”

196 trials

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Showing 20 of 196 results

Very early researchNot Yet RecruitingNCT06081153
What this trial is testing

Mechanistic Clinical Trial of PCSK9 Inhibition for AAA

Who this might be right for
Abdominal Aortic Aneurysm
University of Pennsylvania 44
Testing effectiveness (Phase 2)Study completedNCT03043365
What this trial is testing

Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

Who this might be right for
Lipoprotein MetabolismPCSK9Proteomics
National Heart, Lung, and Blood Institute (NHLBI) 37
Post-approval studies (Phase 4)Looking for participantsNCT06909565
What this trial is testing

Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention

Who this might be right for
Percutaneous Coronary InterventionPeripheral Endovascular Intervention
Duke University 6,000
Not applicableStudy completedNCT01109706
What this trial is testing

Relevance of Plasma PCSK9 Concentration as a Biomarker in Acute Coronary Syndrome.

Who this might be right for
Acute Coronary Syndrome
Nantes University Hospital 175
Large-scale testing (Phase 3)Study completedNCT05004675
What this trial is testing

Trial to Evaluate Efficacy and Safety of LIB003 and Inclisiran in High-risk CVD Patients

Who this might be right for
HypercholesterolemiaAtherosclerotic Ischemic Disease
LIB Therapeutics LLC 166
Large-scale testing (Phase 3)Study completedNCT03207945
What this trial is testing

Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)

Who this might be right for
DyslipidemiasCardiovascular DiseasesHIV Infections
University of California, San Francisco 118
Not applicableUnknownNCT06134635
What this trial is testing

Short-term Effect of PCSK9 Inhibitor in Patients With Acute Ischemic Stroke

Who this might be right for
Acute Ischemic Stroke
Xuanwu Hospital, Beijing 80
Large-scale testing (Phase 3)Study completedNCT02729025
What this trial is testing

Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition on Arterial Wall Inflammation in Patients With Elevated Lipoprotein(a) (Lp(a))

Who this might be right for
Subjects With Hyperlipidemia, Dyslipidemia
Amgen 129
Very early researchActive Not RecruitingNCT04862260
What this trial is testing

Cholesterol Disruption in Combination With the Standard of Care in Patients With Advanced Pancreatic Adenocarcinoma

Who this might be right for
Pancreatic Ductal AdenocarcinomaPancreatic CancerPancreas Cancer+1 more
CHU de Quebec-Universite Laval 3
Large-scale testing (Phase 3)Study completedNCT01516879
What this trial is testing

Durable Effect of PCSK9 Antibody CompARed wiTh placEbo Study

Who this might be right for
Hypercholesterolemia
Amgen 905
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07061535
What this trial is testing

Sintilimab Combined With Tafolecimab and Chemotherapy as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer

Who this might be right for
Extensive-stage Small Cell Lung Cancer (ES-SCLC)Extensive Stage Lung Small Cell CancerExtensive-Stage Small-Cell Lung Cancer+1 more
Second Affiliated Hospital, School of Medicine, Zhejiang University 40
Not applicableStudy completedNCT07409636
What this trial is testing

Assess the Real-World Effectiveness of Inclisiran and PCSK9 mAbs in Chinese Hypercholesterolemia Adult Patients

Who this might be right for
HypercholesterolemiaMixed Dyslipidemia
Novartis Pharmaceuticals 11,991
Not applicableStudy completedNCT00847782
What this trial is testing

An Experimental Medicine Study to Evaluate Serum Biomarkers of Lipid Metabolism

Who this might be right for
Atherosclerosis
Bristol-Myers Squibb 150
Large-scale testing (Phase 3)Study completedNCT01763827
What this trial is testing

Monoclonal Antibody Against PCSK9 to Reduce Elevated LDL-C in Subjects Currently Not Receiving Drug Therapy for Easing Lipid Levels-2

Who this might be right for
Hyperlipidemia
Amgen 615
Testing effectiveness (Phase 2)Study completedNCT01604824
What this trial is testing

Alirocumab in Participants With Autosomal Dominant Hypercholesterolemia (ADH) and Gain-of-Function Mutations (GOFm) of the Proprotein Convertase Subtilisin Kexin 9 (PCSK9) Gene or Loss-of-Function Mutations (LOFm) of the Apolipoprotein (Apo) B Gene

Who this might be right for
Hypercholesterolemia
Regeneron Pharmaceuticals 23
Post-approval studies (Phase 4)Study completedNCT02948777
What this trial is testing

Effects of PCSK9 Inhibition by Evolocumab on Postprandial Lipid Metabolism in Type 2 Diabetes

Who this might be right for
Type 2 Diabetes Mellitus
Marja-Riitta Taskinen 14
Not applicableUnknownNCT05043740
What this trial is testing

PCSK9 Inhibitor on ACS Patients With Multivessel Disease and Relatively Low LDL-C Level in Chinese Population

Who this might be right for
Acute Coronary Syndrome
Second Xiangya Hospital of Central South University 1,360
Large-scale testing (Phase 3)Active Not RecruitingNCT06492291
What this trial is testing

Open-label Extension Study of Enlicitide Decanoate (MK-0616/Enlicitide Oral PCSK9 Inhibitor) in Adults With Hypercholesterolemia (MK-0616-019) CORALreef Extension

Who this might be right for
Hypercholesterolemia
Merck Sharp & Dohme LLC 3,000
Large-scale testing (Phase 3)Study completedNCT07295418
What this trial is testing

SAL003 in Participants With Hypercholesterolemia and Mixed Dyslipidemia

Who this might be right for
Hyperlipidemias
Shenzhen Salubris Pharmaceuticals Co., Ltd. 618
Large-scale testing (Phase 3)Active Not RecruitingNCT05360446
What this trial is testing

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

Who this might be right for
Coronary Artery Disease
Novartis Pharmaceuticals 610
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