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Results for “PD-(L)1”

83 trials

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Showing 20 of 83 results

Large-scale testing (Phase 3)Ended earlyNCT03626545
What this trial is testing

Phase III Study Evaluating Efficacy and Safety of Canakinumab in Combination With Docetaxel in Adult Subjects With Non-small Cell Lung Cancers as a Second or Third Line Therapy

Who this might be right for
Non-Small-Cell Lung
Novartis Pharmaceuticals 245
Post-approval studies (Phase 4)Not Yet RecruitingNCT07004335
What this trial is testing

Efficacy and Safety of Iparomlimab and Tuvonralimab Injection in Combination With Bevacizumab After Progression on Anti-PD-(L)1 Therapy in Advanced Melanoma: A Prospective, Single-Arm, Exploratory Clinical Study

Who this might be right for
PD-(L)1CTLA-4Advanced Melanoma+3 more
Hebei Medical University Fourth Hospital 40
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07045805
What this trial is testing

Phase II Study of QL1706 Combined With Paclitaxel and Bevacizumab for Second-Line Immune Rechallenge in Gastric Cancer

Who this might be right for
Gastric Cancer (GC)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School 66
Early research (Phase 1)Study completedNCT05225584
What this trial is testing

Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid Tumors

Who this might be right for
Non Hodgkin Lymphoma (NHL)Peripheral T-cell Lymphoma (PTCL)Cutaneous T-Cell Lymphoma (CTCL)+3 more
Kymera Therapeutics, Inc. 56
Testing effectiveness (Phase 2)Active Not RecruitingNCT05081609
What this trial is testing

Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies

Who this might be right for
Advanced Solid TumorLocally Advanced Solid TumorMetastatic Solid Tumor+10 more
Ascendis Pharma Oncology Division A/S 320
Not applicableLooking for participantsNCT06693440
What this trial is testing

The Immune Assessment of PD-1 Antibody Therapy in Tumor

Who this might be right for
Efficacy, TeamAdverse Event
Quanli Gao 3,000
Testing effectiveness (Phase 2)Study completedNCT06029127
What this trial is testing

Gimistotug (BGB-A445) in Combination With Other Investigational Agents in Participants With Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
BeiGene 35
Large-scale testing (Phase 3)Looking for participantsNCT06928389
What this trial is testing

Ivonescimab in Combination With Docetaxel in Advanced Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
Akeso 536
Testing effectiveness (Phase 2)Looking for participantsNCT07049926
What this trial is testing

Substudy 03C: A Study of Combination Therapies in Participants With Renal Cell Carcinoma With Recurrent Disease During or After Anti-PD-(L)1 Therapy (MK-3475-03C/KEYMAKER-U03)

Who this might be right for
Renal Cell Carcinoma
Merck Sharp & Dohme LLC 140
Testing effectiveness (Phase 2)Looking for participantsNCT07288034
What this trial is testing

Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

Who this might be right for
Lung Non-Small Cell CarcinomaStage IIIB Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8
City of Hope Medical Center 535
Testing effectiveness (Phase 2)Study completedNCT04993677
What this trial is testing

SEA-CD40 Given With Other Drugs in Cancers

Who this might be right for
MelanomaCarcinoma, Non-Small- Cell Lung
Seagen Inc. 77
Testing effectiveness (Phase 2)Active Not RecruitingNCT03607890
What this trial is testing

Study of Nivolumab and Relatlimab in Advanced Mismatch Repair Deficient Cancers Resistant to Prior PD-(L)1 Inhibitor

Who this might be right for
Refractory MSI - H Solid Tumors Prior of PD-(L) 1 TherapyMSI-H Tumors
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 38
Testing effectiveness (Phase 2)Ended earlyNCT03606174
What this trial is testing

Sitravatinib in Combination With PD-(L)1 Checkpoint Inhibitor Regimens in Patients With Advanced or Metastatic Urothelial Carcinoma

Who this might be right for
Urothelial CarcinomaUrothelial Carcinoma BladderUrothelial Carcinoma Ureter+2 more
Mirati Therapeutics Inc. 260
Not applicableNot Yet RecruitingNCT07186868
What this trial is testing

QL706 + Chemo ± Bevacizumab in Anti-PD-(L)1-Resistant R/M Cervical Cancer

Who this might be right for
Recurrent Cervical CancerMetastatic Cervical Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences 25
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07472322
What this trial is testing

ASTX727 & Retifanlimab-dlwr for Advanced Merkel Cell After Progression on Anti-PD-(L)1

Who this might be right for
Merkel Cell CarcinomaMerkel Cell Carcinoma, Stage IIIMerkel Cell Carcinoma, Stage IV
University of Wisconsin, Madison 31
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07219459
What this trial is testing

Visugromab, Nivolumab and a Tyrosine Kinase Inhibitor (TKI) Compared to Double Placebo and a TKI in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure

Who this might be right for
Unresectable or Metastatic Hepatocellular CarcinomaFailure of First-Line Treatment That Included an Anti PD-(L)1 CompoundChild-Pugh A Hepatocellular Carcinoma
CatalYm GmbH 104
Early research (Phase 1)Looking for participantsNCT07210320
What this trial is testing

PK/PD Study of IN-001 Sublingual Spray in Healthy Adults

Who this might be right for
Food AllergyAnaphylaxisFood Hypersensitivity+1 more
Insignis Therapeutics, Inc. 30
Testing effectiveness (Phase 2)Looking for participantsNCT06731270
What this trial is testing

Diclofenac for the Treatment of Patients With Metastatic Non-small Cell Lung Cancer on Single Agent Immunotherapy

Who this might be right for
Advanced Lung Non-Small Cell CarcinomaMetastatic Lung Non-Small Cell CarcinomaStage III Lung Cancer AJCC v8+1 more
Emory University 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT04622007
What this trial is testing

Tomivosertib Combined With Pembrolizumab in Subjects With PD-L1 Positive NSCLC (KICKSTART)

Who this might be right for
Non-small Cell Lung Cancer
Effector Therapeutics 68
Early research (Phase 1)Study completedNCT03562494
What this trial is testing

VY-AADC02 for Parkinson's Disease With Motor Fluctuations (RESTORE-1)

Who this might be right for
Parkinson's Disease
Neurocrine Biosciences 14
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