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Results for “PNH - Paroxysmal Nocturnal Hemoglobinuria”

178 trials

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Showing 20 of 178 results

Early research (Phase 1)Looking for participantsNCT07256301
What this trial is testing

A Phase Ib, Multicenter, Open-Label Study of Multiple-Dose EA5 in Adults With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
PNH - Paroxysmal Nocturnal Hemoglobinuria
Shanghai Lanyi Therapeutics Co., Ltd. 24
Not applicableLooking for participantsNCT06312644
What this trial is testing

Study of Ultomiris® (Ravulizumab) Safety in Pregnancy

Who this might be right for
Ultomiris-exposed Pregnant/ PostpartumPregnancyParoxysmal Nocturnal Hemoglobinuria (PNH)+3 more
Alexion Pharmaceuticals, Inc. 75
Large-scale testing (Phase 3)Study completedNCT06593938
What this trial is testing

Evaluate the Efficacy and Safety of Oral HRS-5965 in Adult Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Chengdu Suncadia Medicine Co., Ltd. 76
Testing effectiveness (Phase 2)Study completedNCT00731328
What this trial is testing

Donor Stem Cell Transplant After Busulfan, Fludarabine, Methylprednisolone, and Antithymocyte Globulin in Treating Patients With Bone Marrow Failure Syndrome

Who this might be right for
LeukemiaMyelodysplastic SyndromesNonmalignant Neoplasm+1 more
Asan Medical Center 15
Testing effectiveness (Phase 2)Study completedNCT05972967
What this trial is testing

Safety and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria Patients With a Sub-optimal Response to Ravulizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Omeros Corporation 12
Not applicableLooking for participantsNCT06606314
What this trial is testing

Specified Drug-use Surveillance of Fabhalta Capsules

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Novartis Pharmaceuticals 100
Not applicableLooking for participantsNCT04645199
What this trial is testing

National Longitudinal Cohort of Hematological Diseases

Who this might be right for
Multiple MyelomaAcute Myeloid LeukemiaHemophilia+14 more
Institute of Hematology & Blood Diseases Hospital, China 2,300
Large-scale testing (Phase 3)Study completedNCT00122304
What this trial is testing

Study of Safety in Hemolytic Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Treated With Eculizumab

Who this might be right for
Hemoglobinuria, Paroxysmal
Alexion Pharmaceuticals, Inc. 85
Large-scale testing (Phase 3)Ended earlyNCT04162470
What this trial is testing

REGN3918 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate Its Long Term Safety, Efficacy and Tolerability.

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Regeneron Pharmaceuticals 24
Early research (Phase 1)Study completedNCT06490991
What this trial is testing

Comparison of HRS-5965 Capsules and Tablets in Healthy Subjects

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria，IgA Nephropathy
Chengdu Suncadia Medicine Co., Ltd. 16
Testing effectiveness (Phase 2)Study completedNCT02598583
What this trial is testing

Dose-Escalation Study of ALXN1210 IV in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
PNH
Alexion Pharmaceuticals, Inc. 13
Large-scale testing (Phase 3)Study completedNCT04058158
What this trial is testing

Compare SB12 (Proposed Eculizumab Biosimilar) to Soliris in Subjects With Paroxysmal Nocturnal Haemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Samsung Bioepis Co., Ltd. 50
Not applicableStudy completedNCT00039923
What this trial is testing

Transfer of GPI-Linked Proteins to Transfused Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Hemoglobinuria
National Heart, Lung, and Blood Institute (NHLBI) 7
Early research (Phase 1)Study completedNCT00012376
What this trial is testing

Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer

Who this might be right for
Accelerated Phase Chronic Myelogenous LeukemiaAdult Acute Myeloid Leukemia With 11q23 (MLL) AbnormalitiesAdult Acute Myeloid Leukemia With Del(5q)+15 more
National Cancer Institute (NCI) 35
Testing effectiveness (Phase 2)Active Not RecruitingNCT00544115
What this trial is testing

Donor Peripheral Stem Cell Transplant in Treating Patients With Advanced Hematologic Cancer or Other Disorders

Who this might be right for
Chronic Myeloproliferative DisordersGraft Versus Host DiseaseLeukemia+5 more
City of Hope Medical Center 260
Testing effectiveness (Phase 2)UnknownNCT01760096
What this trial is testing

Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)

Who this might be right for
Paroxysmal Nocturnal HemoglobinuriaHemoglobinuriaHemoglobinuria, Paroxysmal+6 more
Institute of Hematology & Blood Diseases Hospital, China 50
Testing effectiveness (Phase 2)Ended earlyNCT05116774
What this trial is testing

BCX9930 for the Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) in Participants With Inadequate Response to C5 Inhibitor Therapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
BioCryst Pharmaceuticals 12
Not applicableStudy completedNCT00856388
What this trial is testing

Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure Disorders

Who this might be right for
Accelerated Phase Chronic Myelogenous LeukemiaAcute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic SyndromeAdult Acute Lymphoblastic Leukemia in Remission+97 more
Roswell Park Cancer Institute 62
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07387302
What this trial is testing

SLN12140 in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) in China

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Linno Pharmaceuticals, Inc. 10
Testing effectiveness (Phase 2)Study completedNCT02605993
What this trial is testing

Open-label, Multiple Ascending Dose Study of Ravulizumab (ALXN1210) in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal HemoglobinuriaPNH
Alexion Pharmaceuticals, Inc. 26
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