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Results for “PSEN1 Mutation”

6 trials

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Showing 6 of 6 results

Testing effectiveness (Phase 2)Study completedNCT03977584
What this trial is testing

Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease

Who this might be right for
Alzheimer Disease
Hoffmann-La Roche 114
Large-scale testing (Phase 3)Not Yet RecruitingNCT06996730
What this trial is testing

Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's Disease

Who this might be right for
Autosomal Dominant Alzheimers DiseaseEarly Onset Alzheimer DiseaseAlzheimers Disease
Banner Health 240
Not applicableLooking for participantsNCT00869817
What this trial is testing

Dominantly Inherited Alzheimer Network (DIAN)

Who this might be right for
Alzheimer's Disease
Washington University School of Medicine 700
Testing effectiveness (Phase 2)Study completedNCT01998841
What this trial is testing

Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers to Evaluate Efficacy and Safety in the Treatment of Autosomal-Dominant Alzheimer's Disease (AD), Including a Placebo-Treated Non-Carrier Cohort

Who this might be right for
Alzheimer's Disease
Genentech, Inc. 252
Early research (Phase 1)Looking for participantsNCT06372821
What this trial is testing

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK

Who this might be right for
Alzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more
University College, London 10
Testing effectiveness (Phase 2)Study completedNCT04413344
What this trial is testing

Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease

Who this might be right for
Familial Alzheimer Disease (FAD)PSEN1 Mutation
Kyoto University 8