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Results for “PTEN”

102 trials

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Showing 20 of 102 results

Testing effectiveness (Phase 2)Ended earlyNCT04216472
What this trial is testing

Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations

Who this might be right for
Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage IA Breast Cancer AJCC v8Anatomic Stage IB Breast Cancer AJCC v8+19 more
M.D. Anderson Cancer Center 6
Early research (Phase 1)Study completedNCT01430572
What this trial is testing

Pazopanib and Everolimus in PI3KCA Mutation Positive/PTEN Loss Patients

Who this might be right for
Advanced CancersSolid Tumors
M.D. Anderson Cancer Center 62
Testing effectiveness (Phase 2)Study completedNCT00975819
What this trial is testing

Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies

Who this might be right for
Kaposiform HemangioendotheliomasTufted AngiomaCapillary Venous Lymphatic Malformation+6 more
Denise Martin Adams 61
Early research (Phase 1)Study completedNCT05300048
What this trial is testing

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Who this might be right for
Advanced Solid TumorPIK3CA MutationPTEN Loss of Function Mutation
Faeth Therapeutics 34
Not applicableLooking for participantsNCT07297134
What this trial is testing

PTEN and Organ-Specific microRNAs in Metastatic Breast Cancer

Who this might be right for
Breast CancerMetastatic Breast CancermiRNAs+1 more
Atlas University 160
Testing effectiveness (Phase 2)WithdrawnNCT06080165
What this trial is testing

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

Who this might be right for
PTEN Gene MutationPTEN Hamartoma Tumor SyndromePTEN Hamartoma Syndrome
Stanford University
Not applicableStudy completedNCT07416500
What this trial is testing

BRCA1, RASSF1A and PTEN Methylation in Breast Lesions of Uncertain Malignant Potential

Who this might be right for
Breast CancerBreast Lesions of Uncertain Malignant Potential (B3 Lesions)
Institute of Oncology Ljubljana 301
Early research (Phase 1)Study completedNCT03317119
What this trial is testing

Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

Who this might be right for
Metastatic Colon CarcinomaMetastatic Colorectal CarcinomaMetastatic Rectal Carcinoma+22 more
City of Hope Medical Center 26
Testing effectiveness (Phase 2)Study completedNCT01068132
What this trial is testing

Prognostic Factors for Patients With Advanced Colorectal Cancer Treated With Cetuximab.

Who this might be right for
Colorectal Cancer
Regione Lombardia 54
Not applicableLooking for participantsNCT03050268
What this trial is testing

Familial Investigations of Childhood Cancer Predisposition

Who this might be right for
Acute LeukemiaAdenomatous PolyposisAdrenocortical Carcinoma+43 more
St. Jude Children's Research Hospital 1,500
Testing effectiveness (Phase 2)UnknownNCT04042831
What this trial is testing

Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

Who this might be right for
Bile Duct AdenocarcinomaFanconi Anemia Complementation Group Gene MutationMetastatic Bile Duct Carcinoma+1 more
Academic and Community Cancer Research United 36
Not applicableUnknownNCT03971318
What this trial is testing

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Who this might be right for
Lymphoma, Non-HodgkinLymphoblastic Lymphoma, ChildhoodPTEN Loss+2 more
Sun Yat-sen University 300
Testing effectiveness (Phase 2)Study completedNCT01276379
What this trial is testing

Study Evaluating Biomarkers in Patients With Colorectal Cancer and Native KRAS Treated With Chemotherapy + Cetuximab

Who this might be right for
Colorectal Cancer
Grupo Espanol Multidisciplinario del Cancer Digestivo 221
Testing effectiveness (Phase 2)Active Not RecruitingNCT05498896
What this trial is testing

Investigate the Contribution of Ipatasertib to Neoadjuvant Chemotherapy Plus Atezolizumab in TNBC

Who this might be right for
Triple Negative Breast Cancer
Queen Mary University of London 146
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439149
What this trial is testing

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 24
Testing effectiveness (Phase 2)Study completedNCT00317720
What this trial is testing

Trastuzumab and RAD001 in Patients With Human Epidermal Growth Receptor 2 (HER-2) Overexpressing Breast Cancer

Who this might be right for
Breast CancerNeoplasm Metastasis
M.D. Anderson Cancer Center 40
Testing effectiveness (Phase 2)Ended earlyNCT00881725
What this trial is testing

Pre-operative Metformin in Prostate Cancer

Who this might be right for
Prostate Cancer
University Health Network, Toronto 24
Testing effectiveness (Phase 2)Ended earlyNCT04737109
What this trial is testing

Neoadjuvant Androgen Deprivation, Darolutamide, and Ipatasertib in Men With Localized, High Risk Prostate Cancer

Who this might be right for
Castrate Resistant Prostate Cancer
David VanderWeele 6
Large-scale testing (Phase 3)Study completedNCT01572727
What this trial is testing

The Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Activation

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 416
Testing effectiveness (Phase 2)Study completedNCT03709446
What this trial is testing

Leflunomide in Previously Treated Metastatic Triple Negative Cancers

Who this might be right for
Breast NeoplasmsBreast DiseasesMetastatic Triple Negative Breast Cancer
Joseph Sparano 17
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