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Results for “PTEN”

103 trials

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Showing 20 of 103 results

Testing effectiveness (Phase 2)Study completedNCT01802320
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

Who this might be right for
Colon Mucinous AdenocarcinomaColon Signet Ring Cell AdenocarcinomaRectal Mucinous Adenocarcinoma+13 more
National Cancer Institute (NCI) 18
Large-scale testing (Phase 3)Active Not RecruitingNCT06764186
What this trial is testing

A Phase IIIB Study to Evaluate the Use of Capivasertib in Combination With Fulvestrant in Patients With Advanced Breast Cancer Who Have Relapsed/Progressed on ET and CDK4/6 Inhibitor Reflecting Real World Clinical Practice in Spain

Who this might be right for
Locally Advanced or Metastatic Breast Cancer
AstraZeneca 101
Early research (Phase 1)Study completedNCT01430572
What this trial is testing

Pazopanib and Everolimus in PI3KCA Mutation Positive/PTEN Loss Patients

Who this might be right for
Advanced CancersSolid Tumors
M.D. Anderson Cancer Center 62
Not applicableStudy completedNCT03680924
What this trial is testing

Access to Resources for Patients With PTEN Hamartoma Tumor Syndrome

Who this might be right for
PTEN Gene Mutation
University of South Florida 13
Testing effectiveness (Phase 2)Ended earlyNCT02822482
What this trial is testing

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss

Who this might be right for
Carcinoma, Squamous Cell of Head and Neck
UNICANCER 11
Testing effectiveness (Phase 2)Ended earlyNCT01870726
What this trial is testing

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

Who this might be right for
c-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBM
Novartis Pharmaceuticals 43
Early research (Phase 1)Study completedNCT01458067
What this trial is testing

A Phase I/IIa, First Time in Human, Study of GSK2636771 in Subjects With Advanced Solid Tumors With Phosphatase and Tensin Homolog (PTEN) Deficiency

Who this might be right for
Cancer
GlaxoSmithKline 30
Testing effectiveness (Phase 2)UnknownNCT03273595
What this trial is testing

Lapatinib Plus Chemotherapy Versus Trastuzumab Plus Chemotherapy in HER2-positive Breast Cancer

Who this might be right for
Neoplasms, Breast
Xijing Hospital 100
Testing effectiveness (Phase 2)Study completedNCT00975819
What this trial is testing

Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies

Who this might be right for
Kaposiform HemangioendotheliomasTufted AngiomaCapillary Venous Lymphatic Malformation+6 more
Denise Martin Adams 61
Testing effectiveness (Phase 2)UnknownNCT04690725
What this trial is testing

TQB3525 for Advanced Bone Sarcomas With PI3KA Mutations or PTEN Loss

Who this might be right for
Safety IssuesEfficacy, Self
Peking University People's Hospital 29
Early research (Phase 1)Study completedNCT01884285
What this trial is testing

AZD8186 First Time In Patient Ascending Dose Study

Who this might be right for
Advanced Castrate-resistant Prostate Cancer CRPCSquamous Non-Small Cell Lung Cancer sqNSCLCTriple Negative Breast Cancer TNBC
AstraZeneca 147
Early research (Phase 1)Study completedNCT03317119
What this trial is testing

Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery

Who this might be right for
Metastatic Colon CarcinomaMetastatic Colorectal CarcinomaMetastatic Rectal Carcinoma+22 more
City of Hope Medical Center 26
Not applicableLooking for participantsNCT06712095
What this trial is testing

Video Capsule Examination in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromeLi Fraumeni SyndromePTEN Hamartoma Syndrome+7 more
Royal Marsden NHS Foundation Trust 25
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05540275
What this trial is testing

Tislelizumab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for Bevacizumab Refractory Recurrent Glioblastoma

Who this might be right for
Recurrent Glioblastoma
Henan Provincial People's Hospital 30
Not applicableLooking for participantsNCT03050268
What this trial is testing

Familial Investigations of Childhood Cancer Predisposition

Who this might be right for
Acute LeukemiaAdenomatous PolyposisAdrenocortical Carcinoma+43 more
St. Jude Children's Research Hospital 1,500
Not applicableUnknownNCT05111080
What this trial is testing

Partial PTEN Deletion in Breast Cancer

Who this might be right for
PTEN Gene Deletion
Assiut University 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT06400238
What this trial is testing

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Expression (MATCH - Subprotocol Z1H)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more
National Cancer Institute (NCI) 35
Testing effectiveness (Phase 2)Ended earlyNCT00387894
What this trial is testing

Erlotinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Who this might be right for
Adult Brain Tumors
Michael Prados 6
Not applicableStudy completedNCT04873206
What this trial is testing

Diagnostic and Prognostic Value of PTEN Expression in Functional and Pathological Endometrial Biopsies

Who this might be right for
Endometrial HyperplasiaEndometrial Adenocarcinoma
Sohag University 80
Large-scale testing (Phase 3)Ended earlyNCT04251533
What this trial is testing

Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss

Who this might be right for
Triple Negative Breast Neoplasms
Novartis Pharmaceuticals 137
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