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Results for “PTEN”

103 trials

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Active, Not Recruiting
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Showing 20 of 103 results

Early research (Phase 1)Study completedNCT03207529
What this trial is testing

Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer

Who this might be right for
Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+15 more
M.D. Anderson Cancer Center 18
Large-scale testing (Phase 3)Active Not RecruitingNCT04493853
What this trial is testing

Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency

Who this might be right for
Hormone-Sensitive Prostate Cancer
AstraZeneca 1,012
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439175
What this trial is testing

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 70
Testing effectiveness (Phase 2)Study completedNCT04740190
What this trial is testing

Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd

Who this might be right for
Recurrent GliomaRecurrent GlioblastomaPoly ADP Ribose Polymerase (PARP) Inhibitor+2 more
The University of Hong Kong 33
Testing effectiveness (Phase 2)Ended earlyNCT00881725
What this trial is testing

Pre-operative Metformin in Prostate Cancer

Who this might be right for
Prostate Cancer
University Health Network, Toronto 24
Testing effectiveness (Phase 2)Ended earlyNCT00387894
What this trial is testing

Erlotinib in Treating Patients With Recurrent Glioblastoma Multiforme or Gliosarcoma

Who this might be right for
Adult Brain Tumors
Michael Prados 6
Testing effectiveness (Phase 2)Ended earlyNCT04216472
What this trial is testing

Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations

Who this might be right for
Anatomic Stage I Breast Cancer AJCC v8Anatomic Stage IA Breast Cancer AJCC v8Anatomic Stage IB Breast Cancer AJCC v8+19 more
M.D. Anderson Cancer Center 6
Not applicableLooking for participantsNCT05420064
What this trial is testing

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Who this might be right for
BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more
Memorial Sloan Kettering Cancer Center 1,000
Not applicableWithdrawnNCT00173407
What this trial is testing

PTEN and IGFBP-3 Correlation in Ovarian Carcinoma Invasion

Who this might be right for
Ovarian Cancer
National Taiwan University Hospital
Large-scale testing (Phase 3)Study completedNCT01572727
What this trial is testing

The Experimental Drug BKM120 With Paclitaxel in Patients With HER2 Negative, Locally Advanced or Metastatic Breast Cancer, With or Without PI3K Activation

Who this might be right for
Breast Cancer
Novartis Pharmaceuticals 416
Not applicableLooking for participantsNCT02573636
What this trial is testing

The Predictive Value of Coexisting TMPRSS2-ERG Gene Fusion and PTEN Deletion in Prostate Cancer Patients with Biochemical Failure Status Post Salvage or Radical Radiation Therapy

Who this might be right for
Prostate Cancer
Sir Mortimer B. Davis - Jewish General Hospital 208
Early research (Phase 1)Ended earlyNCT04770246
What this trial is testing

TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

Who this might be right for
Advanced or Metastatic Solid Tumors Irrespective of Gene AlterationsAdvanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations
Taiho Oncology, Inc. 17
Early research (Phase 1)Study completedNCT02215096
What this trial is testing

Dose-finding Study of GSK2636771 When Administered in Combination With Enzalutamide in Male Subjects With Metastatic Castration-Resistant Prostate Cancer

Who this might be right for
Neoplasms
GlaxoSmithKline 37
Early research (Phase 1)Study completedNCT01430572
What this trial is testing

Pazopanib and Everolimus in PI3KCA Mutation Positive/PTEN Loss Patients

Who this might be right for
Advanced CancersSolid Tumors
M.D. Anderson Cancer Center 62
Not applicableStudy completedNCT02724501
What this trial is testing

Studies of the Tumour Suppressor Gene PTEN - Endometrial Cancer

Who this might be right for
Endometrial Neoplasms
University Health Network, Toronto 217
Not applicableUnknownNCT01514565
What this trial is testing

Tumor Suppressor Status as a Predictor of Chemotherapy Response in Triple Negative Breast Cancer

Who this might be right for
Breast Cancer
Thomas Jefferson University 70
Testing effectiveness (Phase 2)Study completedNCT01068132
What this trial is testing

Prognostic Factors for Patients With Advanced Colorectal Cancer Treated With Cetuximab.

Who this might be right for
Colorectal Cancer
Regione Lombardia 54
Testing effectiveness (Phase 2)Ended earlyNCT05082025
What this trial is testing

Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations

Who this might be right for
Endometrial CancerOvarian Cancer
M.D. Anderson Cancer Center 7
Not applicableStudy completedNCT05671107
What this trial is testing

Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients

Who this might be right for
PTEN Hamartoma Tumor Syndrome
John Carroll University 300
Testing effectiveness (Phase 2)UnknownNCT04690725
What this trial is testing

TQB3525 for Advanced Bone Sarcomas With PI3KA Mutations or PTEN Loss

Who this might be right for
Safety IssuesEfficacy, Self
Peking University People's Hospital 29
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