Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “PTEN Gene Mutation”

34 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 34 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT04439175
What this trial is testing

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 70
Testing effectiveness (Phase 2)Study completedNCT04740190
What this trial is testing

Talazoparib - Carboplatin for Recurrent High-grade Glioma With DDRd

Who this might be right for
Recurrent GliomaRecurrent GlioblastomaPoly ADP Ribose Polymerase (PARP) Inhibitor+2 more
The University of Hong Kong 33
Not applicableLooking for participantsNCT05420064
What this trial is testing

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

Who this might be right for
BRCA1 MutationPOLD1 Gene MutationCDKN2A Mutation+19 more
Memorial Sloan Kettering Cancer Center 1,000
Early research (Phase 1)Ended earlyNCT04770246
What this trial is testing

TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

Who this might be right for
Advanced or Metastatic Solid Tumors Irrespective of Gene AlterationsAdvanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations
Taiho Oncology, Inc. 17
Early research (Phase 1)Study completedNCT01430572
What this trial is testing

Pazopanib and Everolimus in PI3KCA Mutation Positive/PTEN Loss Patients

Who this might be right for
Advanced CancersSolid Tumors
M.D. Anderson Cancer Center 62
Testing effectiveness (Phase 2)UnknownNCT04690725
What this trial is testing

TQB3525 for Advanced Bone Sarcomas With PI3KA Mutations or PTEN Loss

Who this might be right for
Safety IssuesEfficacy, Self
Peking University People's Hospital 29
Testing effectiveness (Phase 2)Study completedNCT01277757
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Advanced Breast Cancer

Who this might be right for
Recurrent Breast CarcinomaStage IIIB Breast CancerStage IIIC Breast Cancer+1 more
National Cancer Institute (NCI) 30
Testing effectiveness (Phase 2)Study completedNCT00971789
What this trial is testing

Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes

Who this might be right for
Cowden's DiseaseHamartoma Syndrome, Multiple
National Cancer Institute (NCI) 18
Early research (Phase 1)Study completedNCT01226316
What this trial is testing

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Who this might be right for
Advanced Solid MalignancySafety and TolerabilityPharmacokinetics+11 more
AstraZeneca 285
Large-scale testing (Phase 3)Not Yet RecruitingNCT07218575
What this trial is testing

Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations

Who this might be right for
Cowden's DiseaseCowden's SyndromeLhermitte-Duclos Disease+6 more
Boston Children's Hospital 60
Testing effectiveness (Phase 2)Looking for participantsNCT05455619
What this trial is testing

Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

Who this might be right for
HR+/HER2-negative Breast CancerMetastatic Breast Cancer
SynDevRx, Inc. 52
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439149
What this trial is testing

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Genetic Changes (MATCH-Subprotocol N)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 24
Testing effectiveness (Phase 2)Study completedNCT02401347
What this trial is testing

Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors

Who this might be right for
Advanced Breast CancerHER2/Neu NegativeTriple-Negative Breast Cancer
Melinda Telli 21
Early research (Phase 1)Ended earlyNCT04586270
What this trial is testing

TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer

Who this might be right for
Advanced or Metastatic Solid Tumors
Taiho Oncology, Inc. 47
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05540275
What this trial is testing

Tislelizumab (One Anti-PD-1 Antibody) Plus Low-dose Bevacizumab for Bevacizumab Refractory Recurrent Glioblastoma

Who this might be right for
Recurrent Glioblastoma
Henan Provincial People's Hospital 30
Testing effectiveness (Phase 2)WithdrawnNCT06080165
What this trial is testing

Sirolimus for Improving Social Abilities in People With PTEN Germline Mutations

Who this might be right for
PTEN Gene MutationPTEN Hamartoma Tumor SyndromePTEN Hamartoma Syndrome
Stanford University
Not applicableStudy completedNCT00898898
What this trial is testing

Studying Tissue Samples From Women With Breast Cancer Who Were Treated on Clinical Trial NCCTG-N9831

Who this might be right for
Breast Cancer
Alliance for Clinical Trials in Oncology 2,837
Not applicableLooking for participantsNCT06712095
What this trial is testing

Video Capsule Examination in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromeLi Fraumeni SyndromePTEN Hamartoma Syndrome+7 more
Royal Marsden NHS Foundation Trust 25
Testing effectiveness (Phase 2)Study completedNCT02449538
What this trial is testing

Study to Evaluate the Safety and Efficacy of Everolimus, in Subjects With PIK3CA Amplification, PTEN Loss and PIK3CA Mutation Refractory Solid Tumors

Who this might be right for
Solid Tumor
Samsung Medical Center 10
Testing effectiveness (Phase 2)Study completedNCT04094675
What this trial is testing

Sirolimus for Cowden Syndrome With Colon Polyposis

Who this might be right for
PTEN Gene MutationPTEN Hamartoma Tumor SyndromePTEN Hamartoma Syndrome+4 more
Ohio State University 5
Next Page