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Results for “PTEN Loss”

21 trials

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Showing 20 of 21 results

Early research (Phase 1)Study completedNCT01430572
What this trial is testing

Pazopanib and Everolimus in PI3KCA Mutation Positive/PTEN Loss Patients

Who this might be right for
Advanced CancersSolid Tumors
M.D. Anderson Cancer Center 62
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439175
What this trial is testing

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 70
Not applicableUnknownNCT03971318
What this trial is testing

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Who this might be right for
Lymphoma, Non-HodgkinLymphoblastic Lymphoma, ChildhoodPTEN Loss+2 more
Sun Yat-sen University 300
Early research (Phase 1)Ended earlyNCT04586270
What this trial is testing

TAS0612 in Participants With Advanced or Metastatic Solid Tumor Cancer

Who this might be right for
Advanced or Metastatic Solid Tumors
Taiho Oncology, Inc. 47
Testing effectiveness (Phase 2)Looking for participantsNCT05593497
What this trial is testing

A Single-Arm Phase II Study of Neoadjuvant Intensified Androgen Deprivation (Leuprolide and Abiraterone Acetate) in Combination With AKT Inhibition (Capivasertib) for High-Risk Localized Prostate Cancer With PTEN Loss

Who this might be right for
High-Risk Prostate Cancer
VA Office of Research and Development 30
Testing effectiveness (Phase 2)UnknownNCT03273595
What this trial is testing

Lapatinib Plus Chemotherapy Versus Trastuzumab Plus Chemotherapy in HER2-positive Breast Cancer

Who this might be right for
Neoplasms, Breast
Xijing Hospital 100
Large-scale testing (Phase 3)Active Not RecruitingNCT04251533
What this trial is testing

Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss

Who this might be right for
Triple Negative Breast Neoplasms
Novartis Pharmaceuticals 137
Testing effectiveness (Phase 2)Study completedNCT01277757
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Advanced Breast Cancer

Who this might be right for
Recurrent Breast CarcinomaStage IIIB Breast CancerStage IIIC Breast Cancer+1 more
National Cancer Institute (NCI) 30
Testing effectiveness (Phase 2)Ended earlyNCT02311764
What this trial is testing

Carboplatin in Castration-resistant Prostate Cancer

Who this might be right for
Prostatic Neoplasm
Aurelius Omlin 16
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439188
What this trial is testing

Testing GSK2636771 as a Potential Targeted Treatment in Cancers With PTEN Loss of Expression (MATCH-Subprotocol P)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 35
Testing effectiveness (Phase 2)Study completedNCT02449538
What this trial is testing

Study to Evaluate the Safety and Efficacy of Everolimus, in Subjects With PIK3CA Amplification, PTEN Loss and PIK3CA Mutation Refractory Solid Tumors

Who this might be right for
Solid Tumor
Samsung Medical Center 10
Testing effectiveness (Phase 2)Active Not RecruitingNCT05490771
What this trial is testing

Testing Copanlisib as a Potential Targeted Treatment in Cancers With PIK3CA Mutations (MATCH-Subprotocol Z1F)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphatic System Neoplasm+3 more
National Cancer Institute (NCI) 35
Early research (Phase 1)Not Yet RecruitingNCT06866795
What this trial is testing

Phase 1 Clinical Study of GT-220F in Subjects With Metastatic Castration Resistant Prostate Cancer (mCRPC)

Who this might be right for
Metastatic Castration Resistant Prostate Cancer
Geode Therapeutics Inc. 42
Testing effectiveness (Phase 2)Active Not RecruitingNCT03131908
What this trial is testing

Study of the Selective PI3K-Beta Inhibitor GSK2636771 in Combination With Pembrolizumab in Patients With Metastatic Melanoma and PTEN Loss

Who this might be right for
Melanoma and Other Malignant Neoplasms of SkinMetastatic Melanoma
M.D. Anderson Cancer Center 27
Testing effectiveness (Phase 2)Ended earlyNCT04737109
What this trial is testing

Neoadjuvant Androgen Deprivation, Darolutamide, and Ipatasertib in Men With Localized, High Risk Prostate Cancer

Who this might be right for
Castrate Resistant Prostate Cancer
David VanderWeele 6
Testing effectiveness (Phase 2)Ended earlyNCT02822482
What this trial is testing

Copanlisib in Association With Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinomas Harboring a PI3KCA Mutation/Amplification and/or a PTEN Loss

Who this might be right for
Carcinoma, Squamous Cell of Head and Neck
UNICANCER 11
Testing effectiveness (Phase 2)Active Not RecruitingNCT06360588
What this trial is testing

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Loss (MATCH - Subprotocol Z1G)

Who this might be right for
Malignant Solid Neoplasm
National Cancer Institute (NCI) 22
Early research (Phase 1)Looking for participantsNCT06944457
What this trial is testing

Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of MPD-1 in Patients With Advanced Solid Tumor

Who this might be right for
CancerSolid Tumor CancerBiomarkers
Pharosgen Co.,Ltd 24
Testing effectiveness (Phase 2)Study completedNCT01802320
What this trial is testing

Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery

Who this might be right for
Colon Mucinous AdenocarcinomaColon Signet Ring Cell AdenocarcinomaRectal Mucinous Adenocarcinoma+13 more
National Cancer Institute (NCI) 18
Early research (Phase 1)Study completedNCT05300048
What this trial is testing

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Who this might be right for
Advanced Solid TumorPIK3CA MutationPTEN Loss of Function Mutation
Faeth Therapeutics 34
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