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Results for “Paroxysmal Nocturnal Hemoglobinuria, PNH”

184 trials

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Showing 20 of 184 results

Testing effectiveness (Phase 2)Study completedNCT00975975
What this trial is testing

Basiliximab #2: In-Vivo Activated T-Cell Depletion to Prevent Graft-Versus_Host Disease (GVHD) After Nonmyeloablative Allotransplantation for the Treatment of Blood Cancer

Who this might be right for
Acute Myelogenous LeukemiaAcute Lymphocytic LeukemiaChronic Myelogenous Leukemia+8 more
Indiana University 17
Large-scale testing (Phase 3)Study completedNCT04060264
What this trial is testing

Clinical Trial of BCD-148 and Soliris® for the Treatment of Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Biocad 28
Testing effectiveness (Phase 2)Study completedNCT06051357
What this trial is testing

Proof of Concept Study to Assess the Efficacy, Safety of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Chengdu Suncadia Medicine Co., Ltd. 26
Early research (Phase 1)Study completedNCT06326814
What this trial is testing

Test if SAR443809 is Tolerated and Safe When Taken as a Single Dose in Healthy Adults

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Sanofi 54
Testing effectiveness (Phase 2)Looking for participantsNCT07187401
What this trial is testing

A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Persistent Anemia
Regeneron Pharmaceuticals 24
Testing effectiveness (Phase 2)Study completedNCT01192399
What this trial is testing

Safety and Efficacy Study of Eculizumab in Paroxysmal Nocturnal Hemoglobinuria Patients

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 29
Testing effectiveness (Phase 2)Study completedNCT03593200
What this trial is testing

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

Who this might be right for
PNH
Apellis Pharmaceuticals, Inc. 4
Post-approval studies (Phase 4)Study completedNCT04320602
What this trial is testing

Ravulizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Currently Treated With High-Dose Eculizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 18
Not applicableStudy completedNCT01020188
What this trial is testing

Study of Global Coagulation Tests in Patients With Paroxysmal Nocturnal Haemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Haemoglobinuria
King's College Hospital NHS Trust 60
Not applicableStudy completedNCT05842486
What this trial is testing

Hematological Response in Patients With Paroxysmal Nocturnal Hemoglobinuria Treated With Anti-C5 Antibody: an External Control Arm Study for Iptacopan Use in Anti-C5 naïve Patients

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Assistance Publique - Hôpitaux de Paris 92
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05646524
What this trial is testing

Study of Efficacy and Safety of NM8074 in Adult PNH Patients Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
NovelMed Therapeutics 12
Testing effectiveness (Phase 2)Study completedNCT04330534
What this trial is testing

First-in-Human Study of BCX9930 in Healthy Volunteers and Patients With PNH

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
BioCryst Pharmaceuticals 168
Testing effectiveness (Phase 2)Study completedNCT03439839
What this trial is testing

Study of Safety, Efficacy, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP023 in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis
Novartis Pharmaceuticals 16
Testing effectiveness (Phase 2)Study completedNCT04811716
What this trial is testing

Pozelimab and Cemdisiran Combination Treatment in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria Who Have Received Pozelimab Monotherapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Regeneron Pharmaceuticals 24
Not applicableStudy completedNCT01192425
What this trial is testing

Paroxysmal Nocturnal Hemoglobinuria (PNH), Level of CD59 on Red and White Blood Cells in Bone Marrow Failure Syndromes

Who this might be right for
Hemoglobinuria
Alexion Pharmaceuticals, Inc. 5,580
Testing effectiveness (Phase 2)Study completedNCT05972967
What this trial is testing

Safety and Efficacy of OMS906 in Paroxysmal Nocturnal Hemoglobinuria Patients With a Sub-optimal Response to Ravulizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Omeros Corporation 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT03157635
What this trial is testing

Study to Assess Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Healthy Volunteers and Participants With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Hemoglobinuria, Nocturnal
Hoffmann-La Roche 59
Testing effectiveness (Phase 2)Looking for participantsNCT06978699
What this trial is testing

A Phase II Study Evaluating the Efficacy and Safety of XH-S003 Capsules in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
PNH - Paroxysmal Nocturnal Hemoglobinuria
S-INFINITY Pharmaceuticals Co., Ltd 24
Not applicableActive Not RecruitingNCT06606314
What this trial is testing

Specified Drug-use Surveillance of Fabhalta Capsules

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Novartis Pharmaceuticals 132
Large-scale testing (Phase 3)Study completedNCT06799546
What this trial is testing

A Phase III Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
PNH
Haisco Pharmaceutical Group Co., Ltd. 73
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