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Results for “Patients With Leptomeningeal Disease”

101 trials

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Showing 20 of 101 results

Testing effectiveness (Phase 2)Looking for participantsNCT07134153
What this trial is testing

Phase I/II Study of Intrathecal/Ommaya T-DXd in HER2-Expressing Breast Cancer With Leptomeningeal/Brain Metastases

Who this might be right for
Breast Cancer
Fudan University 139
Testing effectiveness (Phase 2)Study completedNCT00445965
What this trial is testing

Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer

Who this might be right for
Brain and Central Nervous System TumorsIntraocular MelanomaLung Cancer+7 more
Memorial Sloan Kettering Cancer Center 78
Early research (Phase 1)Active Not RecruitingNCT04192981
What this trial is testing

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

Who this might be right for
Brain MetastasesLeptomeningeal Metastasis
Memorial Sloan Kettering Cancer Center 21
Early research (Phase 1)Active Not RecruitingNCT03423628
What this trial is testing

Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer

Who this might be right for
Recurrent Glioblastoma MultiformePrimary Glioblastoma MultiformeBrain Neoplasms, Malignant+1 more
AstraZeneca 159
Not applicableStudy completedNCT07239102
What this trial is testing

Firmonertinib in the Treatment of EGFR(+) NSCLC Patients With Central Nervous System Metastasis

Who this might be right for
EGFR Positive Non-small Cell Lung CancerCentral Nervous System MetastasisLeptomeningeal Metastasis
Beijing Tiantan Hospital 300
Testing effectiveness (Phase 2)Looking for participantsNCT06901817
What this trial is testing

The Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases

Who this might be right for
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China 97
Early research (Phase 1)Active Not RecruitingNCT06724926
What this trial is testing

Concurrent Azeliragon With Craniospinal Irradiation

Who this might be right for
Solid TumorHigh-grade GliomaLeptomeningeal Metastasis
NYU Langone Health 21
Testing effectiveness (Phase 2)UnknownNCT01818713
What this trial is testing

Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases

Who this might be right for
Meningeal Carcinomatosis
The Netherlands Cancer Institute 6
Not applicableUnknownNCT02803619
What this trial is testing

A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis

Who this might be right for
Non-small Cell Lung CancerLeptomeningeal Metastasis
Peking Union Medical College Hospital 60
Testing effectiveness (Phase 2)UnknownNCT05813522
What this trial is testing

Furmonertinib in Patients With Leptomeningeal Metastases Associated With EGFR Mutated NSCLC

Who this might be right for
Non Small Cell Lung Cancer
First Affiliated Hospital of Zhejiang University 30
Early research (Phase 1)Ended earlyNCT00112619
What this trial is testing

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Who this might be right for
Brain and Central Nervous System TumorsCarcinoma of Unknown PrimaryLeukemia+2 more
Pediatric Brain Tumor Consortium 19
Not applicableLooking for participantsNCT07398599
What this trial is testing

Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study

Who this might be right for
Leptomeningeal MetastasisLung Neoplasms, Non-Small Cell Lung Cancer
Second Affiliated Hospital of Nanchang University 30
Testing effectiveness (Phase 2)Looking for participantsNCT06810804
What this trial is testing

A Phase IIa Study to Evaluate NBQ72S

Who this might be right for
Breast Cancer
Nantong Bencao Quadriga Medical Technology Co. Ltd. 10
Testing effectiveness (Phase 2)Study completedNCT05865990
What this trial is testing

HER3-DXd in Breast Cancer and NSCLC Brain Metastases and Solid Tumor Leptomeningeal Disease

Who this might be right for
Metastatic Breast CancerAdvanced Non-Small Cell Squamous Lung CancerSolid Tumor, Adult
MedSIR 63
Early research (Phase 1)Study completedNCT02423525
What this trial is testing

Safety Study of Afatinib for Brain Cancer

Who this might be right for
Brain Cancer
Santosh Kesari 24
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07833657
What this trial is testing

Combined Intrathecal and Systemic Therapy With Trastuzumab Rezetecan for Leptomeningeal Metastases

Who this might be right for
Leptomeningeal MetastasesSolid Tumors
Jiuda Zhao 28
Testing effectiveness (Phase 2)Looking for participantsNCT05800275
What this trial is testing

Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease

Who this might be right for
Leptomeningeal MetastasisLeptomeningeal DiseaseHER2-positive Metastatic Breast Cancer
UNICANCER 30
Early research (Phase 1)Study completedNCT02253264
What this trial is testing

Trial of Intrathecal Rituximab for Progressive Multiple Sclerosis Patients

Who this might be right for
Primary Progressive Multiple SclerosisSecondary Progressive Multiple Sclerosis
Johns Hopkins University 8
Not applicableUnknownNCT04778800
What this trial is testing

A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)

Who this might be right for
NSCLCBrain MetastasesLeptomeningeal Metastasis
Henan Cancer Hospital 60
Large-scale testing (Phase 3)UnknownNCT03613181
What this trial is testing

ANG1005 in Leptomeningeal Disease From Breast Cancer

Who this might be right for
Leptomeningeal CarcinomatosisLeptomeningeal MetastasesBrain Metastases+1 more
Angiochem Inc 150
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