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Results for “Pediatric Low-grade Glioma”

42 trials

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Showing 20 of 42 results

Large-scale testing (Phase 3)Looking for participantsNCT05566795
What this trial is testing

DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)

Who this might be right for
Low-grade GliomaRapidly Accelerated Fibrosarcoma (RAF) Altered GliomaPediatric Low-grade Glioma
Day One Biopharmaceuticals, Inc. 400
Not applicableApproved For MarketingNCT05760586
What this trial is testing

Expanded Access Program (EAP) for Tovorafenib (DAY101) in RAF-Altered, Relapsed or Refractory Low-Grade Glioma

Who this might be right for
Low-grade Glioma
Day One Biopharmaceuticals, Inc.
Testing effectiveness (Phase 2)Study completedNCT03233204
What this trial is testing

Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmAnn Arbor Stage III Childhood Non-Hodgkin LymphomaAnn Arbor Stage IV Childhood Non-Hodgkin Lymphoma+33 more
National Cancer Institute (NCI) 6
Testing effectiveness (Phase 2)Study completedNCT01497860
What this trial is testing

Vinorelbine for Children With Progressive or Recurrent Low-grade Gliomas

Who this might be right for
Low-grade Glioma
Eugene Hwang 13
Large-scale testing (Phase 3)Not Yet RecruitingNCT07004075
What this trial is testing

FCN-159 Monotherapy Versus Chemotherapy by Investigator's Choice in Pediatric Low-grade Glioma Patients With BRAF Alteration

Who this might be right for
Low-grade GliomaPediatric Low-grade GliomaspLGG With BRAF Alteration
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. 102
Testing effectiveness (Phase 2)Active Not RecruitingNCT06521567
What this trial is testing

Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer

Who this might be right for
MelanomaHodgkin LymphomaHigh and Low Grade Glioma+9 more
GlaxoSmithKline 83
Testing effectiveness (Phase 2)Study completedNCT01288235
What this trial is testing

Proton Radiotherapy for Pediatric Brain Tumors Requiring Partial Brain Irradiation

Who this might be right for
Brain TumorLow Grade GliomaAstrocytoma+2 more
Massachusetts General Hospital 100
Testing effectiveness (Phase 2)Looking for participantsNCT05180825
What this trial is testing

Pediatric Low Grade Glioma - MEKinhibitor TRIal vs Chemotherapy

Who this might be right for
Grade 1 GliomaMixed Glio-neuronal TumorsPleomorphic Xanthoastrocytoma
University Hospital, Strasbourg, France 134
Early research (Phase 1)Study completedNCT00052780
What this trial is testing

Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors

Who this might be right for
Childhood Central Nervous System Germ Cell TumorChildhood Choroid Plexus TumorChildhood Craniopharyngioma+22 more
National Cancer Institute (NCI) 72
Testing effectiveness (Phase 2)Study completedNCT01188096
What this trial is testing

A Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas

Who this might be right for
Brain Tumors
Wake Forest University Health Sciences 23
Early research (Phase 1)Temporarily pausedNCT04485559
What this trial is testing

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

Who this might be right for
Recurrent World Health Organization (WHO) Grade II GliomaLow-grade GliomaHigh Grade Glioma
University of California, San Francisco 50
Not applicableLooking for participantsNCT03761121
What this trial is testing

Developing Fast Pediatric Imaging

Who this might be right for
Pediatric Low-grade Gliomas
Boston Children's Hospital 300
Testing effectiveness (Phase 2)Active Not RecruitingNCT00840047
What this trial is testing

Methionine PET/CT Studies In Patients With Cancer

Who this might be right for
Brain Tumors and/or Solid Tumors IncludingBrain Stem GliomaHigh Grade CNS Tumors+11 more
St. Jude Children's Research Hospital 503
Early research (Phase 1)Looking for participantsNCT06104488
What this trial is testing

Avutometinib for People With Solid Tumor Cancers

Who this might be right for
Refractory CancerCNS TumorsCNS Tumor, Adult+12 more
Memorial Sloan Kettering Cancer Center 23
Testing effectiveness (Phase 2)Study completedNCT03213665
What this trial is testing

Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmAnn Arbor Stage III Hodgkin LymphomaAnn Arbor Stage III Non-Hodgkin Lymphoma+38 more
National Cancer Institute (NCI) 20
Testing effectiveness (Phase 2)Ended earlyNCT00788125
What this trial is testing

Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors

Who this might be right for
Brain and Central Nervous System TumorsChildhood Germ Cell TumorExtragonadal Germ Cell Tumor+8 more
City of Hope Medical Center 7
Testing effectiveness (Phase 2)WithdrawnNCT05222165
What this trial is testing

Study With Infigratinib in Subjects With Advanced Solid and CNS Tumors or Recurrent or Progressive Low-Grade Glioma With Selected FGFR1-3 Alterations

Who this might be right for
Advanced Solid TumorCNS TumorRecurrent WHO Grade II Glioma
Helsinn Healthcare SA
Very early researchLooking for participantsNCT06381570
What this trial is testing

Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas

Who this might be right for
Low-grade Glioma
Daniel Morgenstern 57
Testing effectiveness (Phase 2)Study completedNCT02684058
What this trial is testing

Study of Efficacy and Safety of Dabrafenib in Combination With Trametinib in Pediatric Patients With BRAF V600 Mutation Positive LGG or Relapsed or Refractory HGG Tumors

Who this might be right for
Diffuse AstrocytomaAnaplastic AstrocytomaAstrocytoma+19 more
Novartis Pharmaceuticals 151
Testing effectiveness (Phase 2)UnknownNCT00005084
What this trial is testing

Magnetic Resonance Imaging in Treating Children With Progressive Low-Grade Astrocytoma

Who this might be right for
Brain and Central Nervous System Tumors
Jonsson Comprehensive Cancer Center 24
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