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Results for “Pharmacokinetics and Safety of Elevated Doses”

165 trials

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Showing 20 of 165 results

Early research (Phase 1)Study completedNCT00820885
What this trial is testing

Multi-Dose Tolerability and Pharmacokinetic Study of Teduglutide

Who this might be right for
Pharmacokinetics and Safety of Elevated Doses
Shire 95
Testing effectiveness (Phase 2)Study completedNCT03928353
What this trial is testing

Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects

Who this might be right for
Healthy
SFJ Pharmaceuticals, Inc. 23
Early research (Phase 1)Ended earlyNCT02319369
What this trial is testing

Safety, Tolerability and Pharmacokinetics of Milademetan Alone and With 5-Azacitidine (AZA) in Acute Myelogenous Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)

Who this might be right for
Acute Myelogenous LeukemiaMyelodysplastic Syndrome
Daiichi Sankyo 74
Early research (Phase 1)Study completedNCT02314442
What this trial is testing

An Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Who this might be right for
Hypercholesterolemia
Alnylam Pharmaceuticals 70
Early research (Phase 1)Study completedNCT01263314
What this trial is testing

Safety, Tolerability, and Pharmacokinetics of MK-8266 in Elderly Participants With High Blood Pressure (MK-8266-003)

Who this might be right for
Hypertension
Merck Sharp & Dohme LLC 16
Early research (Phase 1)Study completedNCT05264493
What this trial is testing

Bioavailability Study of Naloxone 5 Milligrams (mg) Intramuscular (IM) Autoinjector

Who this might be right for
Healthy Volunteers
Pfizer 13
Early research (Phase 1)Study completedNCT02559973
What this trial is testing

Pharmacokinetics, Safety, and Tolerability of Depot Buprenorphine at Three Different Molecular Weights in Treatment-Seeking Subjects With Opioid Use Disorder

Who this might be right for
Opioid Use Disorder
Indivior Inc. 47
Early research (Phase 1)Ended earlyNCT01957644
What this trial is testing

Phase I Dose Escalation Trial of Volasertib in Combination With Azacitidine in Patients With MDS or CMML

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, Chronic
Boehringer Ingelheim 16
Testing effectiveness (Phase 2)Ended earlyNCT00388609
What this trial is testing

Multiple-dose Study to Evaluate the Efficacy, Safety and Pharmacokinetics of BMS-646256 in Obese Subjects

Who this might be right for
Obesity
Bristol-Myers Squibb 705
Early research (Phase 1)Not Yet RecruitingNCT07230145
What this trial is testing

A Trial of SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure

Who this might be right for
Heart Failure
Beijing Suncadia Pharmaceuticals Co., Ltd 48
Early research (Phase 1)Study completedNCT05291546
What this trial is testing

Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9035 in Healthy Adult Volunteers and Mildly Hypertensive Participants

Who this might be right for
Healthy Volunteers
Regeneron Pharmaceuticals 93
Early research (Phase 1)Study completedNCT01587365
What this trial is testing

Single Ascending Dose Safety Study of BMS-962476 in Healthy Subjects and Patients With Elevated Cholesterol on Statins

Who this might be right for
Atherosclerosis
Bristol-Myers Squibb 66
Testing effectiveness (Phase 2)Study completedNCT02951312
What this trial is testing

Assessment of the Safety and Ability of a Once-a-day Dose of an Orally Inhaled Medicine [ie, Glycopyrrolate Inhalation Solution = GIS] to Improve Airflow in the Lungs When Delivered With an Electronic eFlow Nebulizer System in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Who this might be right for
Chronic Obstructive Pulmonary Disease
Sunovion Respiratory Development Inc. 12
Early research (Phase 1)Ended earlyNCT00927459
What this trial is testing

Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Liposomal siRNA in Subjects With High Cholesterol

Who this might be right for
Hypercholesterolemia
Arbutus Biopharma Corporation 23
Early research (Phase 1)Study completedNCT05481528
What this trial is testing

Learn How Safe the Study Treatment Elinzanetant is and How it Moves Into, Through and Out of the Body When Given as Single Increasing Doses That Are Higher Than Normally Used Compared to Placebo and Moxifloxacin in Healthy Participants

Who this might be right for
Vasomotor Symptoms as a Sex Hormone-dependent Disorder in Women and MenHot FlashesHealthy Volunteers
Bayer 51
Early research (Phase 1)Study completedNCT02038777
What this trial is testing

PF-04449913 In Japanese Patients With Select Hematologic Malignancies

Who this might be right for
Acute Myeloid Leukemia
Pfizer 48
Early research (Phase 1)Ended earlyNCT04419688
What this trial is testing

A First in Human Study of STT-5058, an Antibody That Binds ApoC3

Who this might be right for
Hypertriglyceridemia
Staten Biotechnology BV 93
Early research (Phase 1)Looking for participantsNCT06501196
What this trial is testing

BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

Who this might be right for
LeukemiaLeukemia, MyeloidLeukemia, Myeloid, Acute+3 more
BlossomHill Therapeutics 170
Early research (Phase 1)Study completedNCT03211403
What this trial is testing

Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level

Who this might be right for
GoutHyperuricemia
Atridia Pty Ltd. 24
Early research (Phase 1)Study completedNCT04259801
What this trial is testing

First Research Study to Look at How Two Medicines, NNC0480-0389 and Semaglutide, Work Together in Healthy People, in People With High Body Weight and in People With Diabetes

Who this might be right for
Healthy VolunteersOverweightObesity+1 more
Novo Nordisk A/S 152
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