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Results for “Phase 1: Advanced or Refractory Solid Tumours”

217 trials

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Showing 20 of 217 results

Early research (Phase 1)Study completedNCT04349969
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Antitumor Activity of AK117 as Monotherapy or in Combination With AK104

Who this might be right for
Neoplasms Malignant
Akesobio Australia Pty Ltd 38
Early research (Phase 1)Looking for participantsNCT05752552
What this trial is testing

Study to Determine the Safety and Pharmacokinetics of DO-2 in Patients With Advanced or Refractory Solid Tumours

Who this might be right for
Adult Solid TumorAdvanced Solid TumorRefractory Tumor+4 more
DeuterOncology 55
Early research (Phase 1)Study completedNCT00161187
What this trial is testing

Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor

Who this might be right for
Cancer
University of Medicine and Dentistry of New Jersey 37
Early research (Phase 1)Ended earlyNCT00359671
What this trial is testing

Treatment With MK6592 and an Anti-cancer Drug in Patients With Advanced Solid Tumors (6592-001)

Who this might be right for
Advanced Solid Tumors
Merck Sharp & Dohme LLC 38
Early research (Phase 1)Study completedNCT01830816
What this trial is testing

Pharmacokinetics Study of Oral Ixazomib (MLN9708) in Relapsed/Refractory Multiple Myeloma and Advanced Solid Tumors Participants With Normal Renal Function or Severe Renal Impairment

Who this might be right for
Multiple MyelomaAdvanced Solid Tumors
Millennium Pharmaceuticals, Inc. 41
Early research (Phase 1)Looking for participantsNCT05341557
What this trial is testing

BPI-371153 in Subjects with Advanced Solid Tumors or Relapsed/Refractory Lymphoma

Who this might be right for
Advanced Solid TumorLymphomaNSCLC+1 more
Betta Pharmaceuticals Co., Ltd. 110
Early research (Phase 1)Study completedNCT02159989
What this trial is testing

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Who this might be right for
Advanced Malignant Solid NeoplasmFibrolamellar CarcinomaMetastatic Malignant Solid Neoplasm+5 more
National Cancer Institute (NCI) 83
Testing effectiveness (Phase 2)UnknownNCT04458389
What this trial is testing

TY101 for Locally Advanced /Metastatic Solid Tumors and Relapsed or Refractory Lymphomas

Who this might be right for
Locally Advanced /Metastatic Solid TumorsRelapsed or Refractory Lymphomas
Tayu Huaxia Biotech Medical Group Co., Ltd. 268
Testing effectiveness (Phase 2)Ended earlyNCT03323398
What this trial is testing

Dose Escalation and Efficacy Study of mRNA-2416 for Intratumoral Injection Alone and in Combination With Durvalumab for Participants With Advanced Malignancies

Who this might be right for
Relapsed/Refractory Solid Tumor Malignancies or LymphomaOvarian Cancer
ModernaTX, Inc. 79
Early research (Phase 1)Temporarily pausedNCT05111561
What this trial is testing

Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer

Who this might be right for
Advanced Malignant Solid NeoplasmMetastatic Malignant Solid NeoplasmRefractory Malignant Solid Neoplasm+2 more
National Cancer Institute (NCI) 42
Early research (Phase 1)Study completedNCT00458731
What this trial is testing

Bevacizumab and Cediranib Maleate in Treating Patients With Metastatic or Unresectable Solid Tumor, Lymphoma, Intracranial Glioblastoma, Gliosarcoma or Anaplastic Astrocytoma

Who this might be right for
Adult Grade III Lymphomatoid GranulomatosisAdult Nasal Type Extranodal NK/T-cell LymphomaAnaplastic Large Cell Lymphoma+59 more
National Cancer Institute (NCI) 57
Testing effectiveness (Phase 2)Looking for participantsNCT02332668
What this trial is testing

Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

Who this might be right for
MelanomaLymphomaSolid Tumor+2 more
Merck Sharp & Dohme LLC 370
Early research (Phase 1)Study completedNCT03406949
What this trial is testing

MGD009/MGA012 Combination in Relapsed/Refractory Cancer

Who this might be right for
Advanced Solid Tumors
MacroGenics 25
Early research (Phase 1)Study completedNCT02592785
What this trial is testing

Phase I Dose Escalation Study of BAY 1163877 (Rogaratinib) in Japanese Subjects With Refractory, Locally Advanced or Metastatic Solid Tumors

Who this might be right for
Neoplasms
Bayer 9
Early research (Phase 1)Study completedNCT00207012
What this trial is testing

MAD Refractory: Solid Tumor QD w/o Break

Who this might be right for
HER2 or EGFR Expressing Advanced Solid Malignancies
Bristol-Myers Squibb 45
Early research (Phase 1)Study completedNCT01404390
What this trial is testing

Japanese BAY80-6946 Monotherapy Phase I Study

Who this might be right for
Neoplasms
Bayer 10
Early research (Phase 1)Study completedNCT01703481
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Adult Participants With Advanced or Refractory Solid Tumors or Lymphoma

Who this might be right for
Tumor or Lymphoma
Janssen Research & Development, LLC 188
Testing effectiveness (Phase 2)Looking for participantsNCT05669430
What this trial is testing

GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

Who this might be right for
Solid Tumor, AdultRefractory CancerEndometrial Carcinoma (EC)+4 more
GV20 Therapeutics 365
Early research (Phase 1)Active Not RecruitingNCT03065387
What this trial is testing

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

Who this might be right for
Advanced Malignant Solid NeoplasmEGFR Gene AmplificationEGFR Gene Mutation+7 more
M.D. Anderson Cancer Center 93
Early research (Phase 1)Looking for participantsNCT06484816
What this trial is testing

TGRX-1942 Chinese Phase I for Advanced Solid Tumor And/or Relapsed/Refractory Hematologic Malignancies

Who this might be right for
Non Small Cell Lung CancerAdvanced Solid TumorHematologic Malignancy
Shenzhen TargetRx Co., Ltd. 90
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