Early research (Phase 1)Study completedNCT02363335What this trial is testingThe Role of Phosphodiesterase Inhibitors in Incretin SecretionWho this might be right forHealthy Volunteers National Institute on Aging (NIA) 29
Not applicableLooking for participantsNCT07488819What this trial is testingImaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974Who this might be right forPost-Traumatic Stress Disorder, PTSDAlcohol Use Disorder (AUD) Yale University 160
Not applicableStudy completedNCT02565030What this trial is testingChronic Thrombo-embolic Pulmonary Hypertension: Classification and Long Term OutcomeWho this might be right forChronic Thromboembolic Pulmonary HypertensionIdiopathic Pulmonary Arterial Hypertension Sheffield Teaching Hospitals NHS Foundation Trust 1,200
Post-approval studies (Phase 4)UnknownNCT00705588What this trial is testingLong Acting Phosphodiesterase 5 Inhibitors as Add-on Therapy for Patients With Pulmonary Hypertension Treated With Prostanoids.Who this might be right forPulmonary Arterial Hypertension Rabin Medical Center 30
Not applicableUnknownNCT02845765What this trial is testingFundus Oculi and Erectile DysfunctionWho this might be right forErectile Dysfunction Ospedale San Raffaele 60
Not applicableTemporarily Not AvailableNCT01406535What this trial is testingImprovement of Myocardial Blood Flow by PhosphoDiesterase 5 Inhibition in Coronary Artery DiseaseWho this might be right forTherapy Refractory Myocardial IschemiaCoronary Artery DiseaseUnsuitable for Surgical or Percutaneous Revascularisation Medical University of Vienna
Large-scale testing (Phase 3)Study completedNCT00246935What this trial is testingLong-term Study of Safety and Efficacy of Roflumilast in Japanese Patients Older Than 40 Years With Chronic Obstructive Pulmonary Disease (APTA-2217-08)Who this might be right forChronic Obstructive Pulmonary Disease (COPD) AstraZeneca 150
Testing effectiveness (Phase 2)WithdrawnNCT04789837What this trial is testingThe Phosphodiesterase 3 Inhibitor Cilostazol as an Adjunct to Conventional Therapy in Patients With OsteoarthritisWho this might be right forOsteoarthritis Sadat City University
Post-approval studies (Phase 4)Study completedNCT00303459What this trial is testingEffects of the Combination of Bosentan and Sildenafil Versus Sildenafil Monotherapy on Pulmonary Arterial Hypertension (PAH)Who this might be right forPulmonary Arterial Hypertension Actelion 334
Not applicableLooking for participantsNCT06232889What this trial is testingDeuterium Metabolic MRI and [18F]FDG PET for Assessment of Treatment Response Following RadioembolizationWho this might be right forFluorodeoxyglucose F18Phosphoric Monoester HydrolasesPhosphoric Diester Hydrolases UMC Utrecht 15
Large-scale testing (Phase 3)Study completedNCT01212770What this trial is testingPALACE 3: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic ArthritisWho this might be right forPsoriatic Arthritis Amgen 505
Large-scale testing (Phase 3)UnknownNCT05594680What this trial is testingCilostazol and Methotrexate in Rheumatoid ArthritisWho this might be right forRheumatoid Arthritis Tanta University 70
Early research (Phase 1)Looking for participantsNCT07223125What this trial is testingJNJ-89862175 for Treatment of Advanced Solid TumorsWho this might be right forAdvanced-stage Solid Tumors Janssen Research & Development, LLC 360
Post-approval studies (Phase 4)Study completedNCT01060020What this trial is testingAcute Hemodynamic Effects of Sildenafil in Patients With Severe Aortic StenosisWho this might be right forAortic Stenosis Washington University School of Medicine 20
Large-scale testing (Phase 3)Study completedNCT01364181What this trial is testingThe Impact of Udenafil on Exercise Capacity in Severe Chronic Obstructive Pulmonary Disease (COPD) PatientsWho this might be right forDyspneaChronic Obstructive Pulmonary DiseasePulmonary Hypertension Seoul National University Hospital 23
Large-scale testing (Phase 3)WithdrawnNCT01960153What this trial is testingPhosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure: Extent of Renal DamageWho this might be right forHeart FailurePulmonary Hypertension Massachusetts General Hospital
Testing effectiveness (Phase 2)Study completedNCT01970176What this trial is testingStudy to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)Who this might be right forCardiomyopathyRenal Impairment Mayo Clinic 20
Testing effectiveness (Phase 2)Study completedNCT02611336What this trial is testingEndocrine Cardiomyopathy: Response to Cyclic GMP PDE5 Inhibitors in Acromegaly CardiomyopathyWho this might be right forAcromegaly Cardiomyopathy Andrea M. Isidori 15
Large-scale testing (Phase 3)Study completedNCT01824290What this trial is testingTadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH)Who this might be right forHypertension, Pulmonary Eli Lilly and Company 35
Large-scale testing (Phase 3)WithdrawnNCT03997097What this trial is testingEfficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart DiseaseWho this might be right forSingle-ventriclePulmonary HypertensionUniventricular Heart University Hospital, Montpellier