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Results for “Pirtobrutinib”

72 trials

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Showing 20 of 72 results

Very early researchLooking for participantsNCT07428707
What this trial is testing

Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib

Who this might be right for
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
National Heart, Lung, and Blood Institute (NHLBI) 30
Large-scale testing (Phase 3)Looking for participantsNCT07516093
What this trial is testing

Study of NX-5948 Versus Pirtobrutinib in R/R CLL/SLL

Who this might be right for
B-cell LymphomaChronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Nurix Therapeutics, Inc. 620
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07812493
What this trial is testing

Pirtobrutinib Plus Methotrexate-Based Chemoimmunotherapy for Systemic DLBCL With CNS Involvement

Who this might be right for
PirtobrutinibImmunochemotherapyDLBCL - Diffuse Large B Cell Lymphoma+1 more
Pengpeng Xu 24
Testing effectiveness (Phase 2)Looking for participantsNCT06553872
What this trial is testing

Phase 2 Open Label Randomized Study of Pirtobrutinib and Brexucabtagene Autoleucel in R/R MCL

Who this might be right for
Mantle Cell Lymphoma
H. Lee Moffitt Cancer Center and Research Institute 60
Early research (Phase 1)Study completedNCT05176314
What this trial is testing

A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LY3527727) and Rosuvastatin in Healthy Participants

Who this might be right for
Healthy
Loxo Oncology, Inc. 32
Testing effectiveness (Phase 2)Active Not RecruitingNCT07162181
What this trial is testing

Long-Term Safety of Pirtobrutinib in Participants With Previously Treated Types of Blood Cancers

Who this might be right for
Lymphoma, Non-HodgkinLeukemia, Lymphocytic, Chronic, B-CellB-cell Lymphoma
Eli Lilly and Company 13
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07548450
What this trial is testing

Mosunetuzumab in Combination With Pirtobrutinib in Patients With Relapsed or Refractory Waldenstrom Macroglobulinemia (MPOWER)

Who this might be right for
Waldenstrom Macroglobulinemia
University of Utah 25
Testing effectiveness (Phase 2)Looking for participantsNCT06333262
What this trial is testing

Fixed Duration Pirtobrutinib and Obinutuzumab in Chronic Lymphocytic Leukemia

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Inhye Ahn 60
Testing effectiveness (Phase 2)Looking for participantsNCT05529069
What this trial is testing

Phase II Study of Pirtobrutinib With Venetoclax In Relapsed-Refractory MCL (Mantle Cell Lymphoma) Patients

Who this might be right for
Mantle Cell LymphomaNon Hodgkin LymphomaHematologic Malignancy
M.D. Anderson Cancer Center 30
Testing effectiveness (Phase 2)Active Not RecruitingNCT06522386
What this trial is testing

GATE1: A Multicenter Phase II Study of Pirtobrutinib, Rituximab and Venetoclax Combination Therapy for Patients With Previously Untreated Mantle Cell Lymphoma

Who this might be right for
Mantle Cell Lymphoma
M.D. Anderson Cancer Center 50
Testing effectiveness (Phase 2)Looking for participantsNCT06588478
What this trial is testing

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Loxo Oncology, Inc. 249
Early research (Phase 1)Study completedNCT06215521
What this trial is testing

Evaluate the Effect of Pirtobrutinib (LOXO-305) on QTc Interval in Healthy Participants

Who this might be right for
Healthy
Eli Lilly and Company 31
Early research (Phase 1)Looking for participantsNCT05990465
What this trial is testing

LV20.19 CAR T-Cells in Combination With Pirtobrutinib for Relapsed, Refractory B-cell Malignancies

Who this might be right for
Non Hodgkin LymphomaDiffuse Large B Cell LymphomaFollicular Lymphoma+3 more
Medical College of Wisconsin 12
Large-scale testing (Phase 3)Active Not RecruitingNCT05023980
What this trial is testing

Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Loxo Oncology, Inc. 309
Early research (Phase 1)Study completedNCT06180954
What this trial is testing

Carbon-14-Labelled [14C] LOXO-305 (Pirtobrutinib) in Healthy Male Participants

Who this might be right for
Healthy
Eli Lilly and Company 9
Early research (Phase 1)Study completedNCT06194214
What this trial is testing

A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Digoxin (P-Glycoprotein Substrate) in Healthy Participants

Who this might be right for
Healthy
Eli Lilly and Company 16
Large-scale testing (Phase 3)Active Not RecruitingNCT04662255
What this trial is testing

Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL)

Who this might be right for
Lymphoma, Mantle-Cell
Loxo Oncology, Inc. 500
Testing effectiveness (Phase 2)Looking for participantsNCT06390956
What this trial is testing

Pirtobrutinib in Combination With Rituximab in Adults With Untreated Marginal Zone Lymphoma (PIONEER-MZL)

Who this might be right for
Marginal Zone Lymphoma
University of Utah 23
Testing effectiveness (Phase 2)Looking for participantsNCT06043674
What this trial is testing

Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

Who this might be right for
Chronic Lymphocytic LeukemiaRichter's Transformation
Christine Ryan 70
Testing effectiveness (Phase 2)WithdrawnNCT06104683
What this trial is testing

Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple Sclerosis

Who this might be right for
Relapsing Multiple SclerosisMultiple Sclerosis
Loxo Oncology, Inc.
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