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Results for “Plexiform Neurofibroma”

79 trials

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Showing 20 of 79 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT02407405
What this trial is testing

MEK 1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis 1 (NF1)Plexiform Neurofibromas (PN)
National Cancer Institute (NCI) 36
Not applicableLooking for participantsNCT06379230
What this trial is testing

A Retrospective Study on Epidemiological Characteristics of Chinese NF1 Patients in Real World (PROMISE)

Who this might be right for
Neurofibromatosis 1Plexiform Neurofibroma
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University 2,000
Testing effectiveness (Phase 2)WithdrawnNCT05825365
What this trial is testing

Selumetinib in Chinese Paediatric With Post-operative NF1-PNs, PhaseⅡ, Double-Blinded, Placebo-Controlled Study

Who this might be right for
Neurofibromatosis Type 1Plexiform NeurofibromasPost-operative
AstraZeneca
Testing effectiveness (Phase 2)Study completedNCT03231306
What this trial is testing

Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1Plexiform Neurofibroma
University of Alabama at Birmingham 45
Testing effectiveness (Phase 2)Ended earlyNCT00326872
What this trial is testing

AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine

Who this might be right for
Neurofibromatosis Type 1Plexiform NeurofibromaSpinal Cord Neurofibroma
National Cancer Institute (NCI) 26
Testing effectiveness (Phase 2)Study completedNCT01673009
What this trial is testing

Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis
Indiana University 36
Not applicableStudy completedNCT00006435
What this trial is testing

Study of Plexiform Neurofibromas in Neurofibromatosis Type 1

Who this might be right for
Plexiform NeurofibromasNF1
National Cancer Institute (NCI) 24
Not applicableActive Not RecruitingNCT00924196
What this trial is testing

Natural History Study of Patients With Neurofibromatosis Type I

Who this might be right for
Neurofibromatosis Type 1Malignant Peripheral Nerve Sheath TumorPlexiform Neurofibroma+2 more
National Cancer Institute (NCI) 259
Testing effectiveness (Phase 2)Active Not RecruitingNCT05309668
What this trial is testing

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 36
Testing effectiveness (Phase 2)Looking for participantsNCT06541847
What this trial is testing

A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1

Who this might be right for
Neurofibromatosis Type 1
Healx Limited 25
Testing effectiveness (Phase 2)Looking for participantsNCT06188741
What this trial is testing

Selumetinib for the Prevention of Plexiform Neurofibroma Growth in NF Type 1

Who this might be right for
Neurofibromatosis 1Plexiform Neurofibroma
University of Alabama at Birmingham 200
Not applicableLooking for participantsNCT06222203
What this trial is testing

Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

Who this might be right for
Neurofibromatosis 1Nerve Sheath Neoplasms
National Cancer Institute (NCI) 225
Not applicableAvailableNCT05028166
What this trial is testing

Individual Patient Compassionate Use of Mirdametinib

Who this might be right for
Neurofibromatosis Type 1-Associated Plexiform NeurofibromasHistiocytic NeoplasmOther MAP-K Pathway Driven Diseases
SpringWorks Therapeutics, Inc.
Early research (Phase 1)Active Not RecruitingNCT05101148
What this trial is testing

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 24
Testing effectiveness (Phase 2)WithdrawnNCT03688568
What this trial is testing

Study of Imatinib in Children With Neurofibromatosis and Airway Tumors

Who this might be right for
Neurofibroma, Plexiform
Indiana University
Post-approval studies (Phase 4)Active Not RecruitingNCT03975829
What this trial is testing

Pediatric Long-Term Follow-up and Rollover Study

Who this might be right for
Diffuse AstrocytomaAnaplastic AstrocytomaAstrocytoma+20 more
Novartis Pharmaceuticals 163
Large-scale testing (Phase 3)Study completedNCT02471339
What this trial is testing

Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain

Who this might be right for
Neurofibromatosis Type 1Plexiform Neurofibromas
National Cancer Institute (NCI) 66
Not applicableLooking for participantsNCT06360406
What this trial is testing

Real-World Treatment Study of Koselugo (Selumetinib)

Who this might be right for
Neurofibromatosis 1Neurofibroma, Plexiform
AstraZeneca 200
Not applicableEnrolling By InvitationNCT05238909
What this trial is testing

Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1

Who this might be right for
Neurofibromatosis 1NF1Neurofibromatosis Type 1
Ann & Robert H Lurie Children's Hospital of Chicago 200
Early research (Phase 1)Study completedNCT00053937
What this trial is testing

Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis Type 1Precancerous Condition
National Cancer Institute (NCI)
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