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Results for “Plexiform Neurofibromas (PN)”

16 trials

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Showing 16 of 16 results

Large-scale testing (Phase 3)Active Not RecruitingNCT04924608
What this trial is testing

Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis 1Plexiform Neurofibroma (PN)
AstraZeneca 145
Testing effectiveness (Phase 2)Active Not RecruitingNCT01362803
What this trial is testing

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Who this might be right for
Neurofibromatosis 1Neurofibromatosis Type 1NF1+1 more
National Cancer Institute (NCI) 99
Early research (Phase 1)Active Not RecruitingNCT04590235
What this trial is testing

Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

Who this might be right for
Neurofibromatosis 1Neurofibroma Plexiform
AstraZeneca 32
Not applicableStudy completedNCT04774289
What this trial is testing

Incidence of Malignant Peripheral Nerve Sheath Tumor (MPNST) Development in Participants With Neurofibromatosis Type 1 (NF1) Receiving and Not Receiving Medical Therapies Directed at Plexiform Neurofibromas (PN)

Who this might be right for
Neurofibromatosis 1Peripheral Nerve Neoplasms, Malignant
National Cancer Institute (NCI) 296
Not applicableApproved For MarketingNCT03259633
What this trial is testing

An Intermediate Access Protocol for Selumetinib for Treatment of Neurofibromatosis Type 1

Who this might be right for
NF type1 With Inoperable Plexiform Neurofibromas
AstraZeneca
Not applicableActive Not RecruitingNCT06175637
What this trial is testing

Observational Study to Evaluate the Effect and Safety of Selumetinib in Pediatric Patients With NF1-PNs

Who this might be right for
Neurofibroma, Plexiform
AstraZeneca 409
Testing effectiveness (Phase 2)Study completedNCT02096471
What this trial is testing

MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1

Who this might be right for
Neurofibromatosis Type 1 and Growing or Symptomatic, Inoperable PN
University of Alabama at Birmingham 19
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06763315
What this trial is testing

Low-dose Selumetinib for the Treatment of Plexiform Neurofibromas in Chinese Children

Who this might be right for
Plexiform Neurofibromas (PN)
West China Hospital 50
Early research (Phase 1)Looking for participantsNCT02390752
What this trial is testing

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

Who this might be right for
Neurofibroma, PlexiformPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, Promyelocytic, Acute+1 more
National Cancer Institute (NCI) 54
Testing effectiveness (Phase 2)Ended earlyNCT01365468
What this trial is testing

Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1)

Who this might be right for
Plexiform Neurofibroma Associated With Neurofibromatosis Type 1
Novartis Pharmaceuticals 9
Early research (Phase 1)Study completedNCT04495127
What this trial is testing

Selumetinib Paediatric NF1 Japan Study

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT02407405
What this trial is testing

MEK 1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

Who this might be right for
Neurofibromatosis 1 (NF1)Plexiform Neurofibromas (PN)
National Cancer Institute (NCI) 36
Not applicableLooking for participantsNCT06222203
What this trial is testing

Surveillance for Malignant Transformation of Neurofibromatosis Type 1 (NF1) Related Peripheral Nerve Sheath Tumors (PNST)

Who this might be right for
Neurofibromatosis 1Nerve Sheath Neoplasms
National Cancer Institute (NCI) 225
Testing effectiveness (Phase 2)Active Not RecruitingNCT05309668
What this trial is testing

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN

Who this might be right for
Neurofibromatosis Type 1
AstraZeneca 36
Testing effectiveness (Phase 2)Study completedNCT02101736
What this trial is testing

Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults

Who this might be right for
NF1NeurofibromatosisPlexiform Neurofibromas
University of Alabama at Birmingham 45
Not applicableEnded earlyNCT05891847
What this trial is testing

Non-interventional Study of Patients With PN NF1 Starting Selumetinib in Russia

Who this might be right for
Neurofibroma
AstraZeneca 150