Post-approval studies (Phase 4)UnknownNCT00268138What this trial is testingElmex Gel Efficacy in Preventing White Spot LesionsWho this might be right forDental Caries Hadassah Medical Organization 314
Not applicableStudy completedNCT03927794What this trial is testingRemineralization of White Spot Lesions Using Self-Assembling Peptide P11-4 in Primary Anterior Teeth A Randomized Clinical TrialWho this might be right forWhite Spot Lesions [Initial Caries] on Smooth Surface of Tooth Ain Shams University 11
Not applicableStudy completedNCT04992481What this trial is testingFluoride Varnish, Ozone, Octenidin and WSLs in Orthodontic PatientsWho this might be right forWhite Spot Lesion of Tooth Pomeranian Medical University Szczecin 150
Early research (Phase 1)UnknownNCT05948228What this trial is testingPrevention of White Spot Lesions Using Bioactive GelWho this might be right forWhite Spot Lesions Cairo University 330
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06797882What this trial is testingPreventive Effects of Silver Diamine Fluoride on Early Enamel CariesWho this might be right forDemineralization, ToothWhite Spot Lesion of ToothFixed Appliances+1 more National University of Malaysia 99
Not applicableActive Not RecruitingNCT07426432What this trial is testingEvaluate the Effect of Fluoride-Releasing Composite Resin on Prevention of White Spot Lesions During Clear Aligner TherapyWho this might be right forWhite Spot LesionsClear Aligner Appliance Mansoura University 24
Testing effectiveness (Phase 2)UnknownNCT03973554What this trial is testingCaries Prevention Potential of Pearl Powder Versus CPP-ACP on Enamel White Spot LesionsWho this might be right forWhite Spot Lesion of Tooth Ruba Alaa El Din Adel El Damarisy 58
Not applicableStudy completedNCT03306433What this trial is testingPrevention of Enamel Demineralization by Use of K18-smooth Surface SealantWho this might be right forDental Caries University of Colorado, Denver 16
Not applicableNot Yet RecruitingNCT07126366What this trial is testingColor Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot LesionsWho this might be right forWhite Spot Lesion of Tooth Cairo University 58
Not applicableUnknownNCT03721198What this trial is testingRMGI Varnish Versus APF Gel in Prevention of White Spot Lesions During Orthodontic TreatmentWho this might be right forWhite Spot Lesion of Tooth Mohamed zidan 16
Testing effectiveness (Phase 2)UnknownNCT04342858What this trial is testingProspective Randomized Controlled Trial for Prevention of Demineralization During Fixed Orthodontic TreatmentWho this might be right forDemineralization, ToothCaries,DentalWhite Spot Lesion The University of Hong Kong 99
Large-scale testing (Phase 3)UnknownNCT04994314What this trial is testingWhite Spot Lesions Prevention During Orthodontic Fixed Appliance Treatment: a Randomized Clinical TrialWho this might be right forWhite Spot Lesion of Tooth University of Baghdad 31
Not applicableNot Yet RecruitingNCT07120243What this trial is testingClinical Effectiveness of Bioactive Silica Based With Calcium ToothpasteWho this might be right forCaries; InitialCaries Active Rawda Hesham Abd ElAziz 20
Not applicableLooking for participantsNCT07325643What this trial is testingEffect of Hydroxyapatite Toothpaste and Mouthwash in Preventing White Spot Lesions During Orthodontic TreatmentWho this might be right forPrevention of White Spot Lesions in Patients Undergoing Orthodontic Treatment Heba Tahseen Almasri 75
Post-approval studies (Phase 4)Active Not RecruitingNCT06696105What this trial is testingAssessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory SettingWho this might be right forWhite Spot LesionsWhite Spot Lesions [Initial Caries] on Smooth Surface of ToothEnamel Hypomineralization King Abdulaziz University 60
Not applicableStudy completedNCT04560478What this trial is testingComparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic PatientsWho this might be right forWhite Spot Lesion Texas A&M University 40
Post-approval studies (Phase 4)Study completedNCT03446690What this trial is testingMI Varnish for the Prevention of White Spot LesionsWho this might be right forWhite Spot LesionOrthodontic Treatment University of Alabama at Birmingham 62
Not applicableUnknownNCT05127889What this trial is testingThe Remineralizing Self-Assembling Peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride White Spot LesionsWho this might be right forPrevention of White Spot Lesions Ain Shams University 39
Not applicableActive Not RecruitingNCT06752291What this trial is testingEFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISED CONTROLLED CLINICAL TRIALWho this might be right forWhite Spot Lesion of ToothGingival InflammationGingival Bleeding+1 more University of Malaya 32
Not applicableStudy completedNCT03440996What this trial is testingComparison of Three Toothpastes for the Prevention and Reduction of White Spot LesionsWho this might be right forWhite Spot LesionOrthodontic TreatmentDecalcification; Teeth University of Alabama at Birmingham 90