Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Primary-progressive Multiple Sclerosis”

128 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 128 results

Large-scale testing (Phase 3)UnknownNCT02220244
What this trial is testing

Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis

Who this might be right for
Multiple Sclerosis
MedDay Pharmaceuticals SA 105
Not applicableUnknownNCT05229861
What this trial is testing

The Influence of HIIT Versus MCT on Cardiorespiratory Fitness in PPMS

Who this might be right for
Primary Progressive Multiple SclerosisExerciseCardiorespiratory Fitness
Klinik Valens 61
Early research (Phase 1)Looking for participantsNCT07085676
What this trial is testing

Phase 1 Study of HBI0101 CAR-T in Refractory B-Cell Autoimmune Diseases

Who this might be right for
Systemic Sclerosis (SSc)Idiopathic Inflammatory Myopathy (IIM)Rheumatoid Arthritis (RA)+6 more
Polina Stepensky 120
Testing effectiveness (Phase 2)Ended earlyNCT01950234
What this trial is testing

ACTH in Progressive Forms of MS

Who this might be right for
Secondary Progressive Multiple SclerosisPrimary Progressive Multiple SclerosisProgressive Relapsing Multiple Sclerosis
University of Minnesota 59
Testing effectiveness (Phase 2)Looking for participantsNCT07477639
What this trial is testing

Treatment of Participants With Primary or Secondary Progressive Multiple Sclerosis

Who this might be right for
Primary Progressive Multiple SclerosisSecondary Progressive Multiple Sclerosis (SPMS)Multiple Sclerosis+2 more
Tr1X, Inc. 39
Large-scale testing (Phase 3)Active Not RecruitingNCT04688788
What this trial is testing

Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis

Who this might be right for
Relapsing Remitting Multiple SclerosisSecondary Progressive Multiple SclerosisPrimary Progressive Multiple Sclerosis
Rigshospitalet, Denmark 600
Not applicableTemporarily pausedNCT04031469
What this trial is testing

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease

Who this might be right for
Gut MicrobiomeGastrointestinal MicrobiomeAutism+77 more
ProgenaBiome 1,000
Testing effectiveness (Phase 2)Study completedNCT01982942
What this trial is testing

Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis

Who this might be right for
Multiple Sclerosis, Primary ProgressiveMultiple Sclerosis, Secondary Progressive
MediciNova 255
Testing effectiveness (Phase 2)Study completedNCT01191996
What this trial is testing

Safety Study of an Immunomodulating Microparticle to Treat Progressive Multiple Sclerosis

Who this might be right for
Secondary Progressive Multiple SclerosisPrimary Progressive Multiple Sclerosis
Innate Immunotherapeutics 34
Large-scale testing (Phase 3)Study completedNCT01433497
What this trial is testing

Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosis

Who this might be right for
Multiple Sclerosis, Secondary ProgressiveMultiple Sclerosis, Primary ProgressiveMultiple Sclerosis, Relapse Free
AB Science 656
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07222956
What this trial is testing

Remibrutinib Using MR Imaging in Relapsing or Progressive MS

Who this might be right for
Multiple Sclerosis (MS) - Relapsing-remittingMultiple Sclerosis (MS) Secondary ProgressiveMultiple Sclerosis (MS) Primary Progressive
Moein Amin 20
Early research (Phase 1)Study completedNCT02506751
What this trial is testing

Open-label Study of Liothyronine in MS

Who this might be right for
Multiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Secondary ProgressiveMultiple Sclerosis, Primary Progressive
Johns Hopkins University 20
Early research (Phase 1)Not Yet RecruitingNCT07562074
What this trial is testing

Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis

Who this might be right for
Multiple SclerosisDepression - Major Depressive DisorderFatigue
University of Calgary 20
Not applicableStudy completedNCT03424538
What this trial is testing

The Effect of Neurorehabilitation Therapy on Postural Control, Mobility and Quality of Life in Multiple Sclerosis Patients

Who this might be right for
Multiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Primary Progressive
Somogy Megyei Kaposi Mór Teaching Hospital 2
Not applicableStudy completedNCT05663853
What this trial is testing

An Observational Biomarker Study in Multiple Sclerosis (MS) Patients

Who this might be right for
Multiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Primary ProgressiveMultiple Sclerosis, Secondary Progressive
LAPIX Therapeutics Inc. 137
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07765212
What this trial is testing

Evaluating the Use of Oral Indapamide to Reduce Disabiltiy Progression in Progressive Multiple Sclerosis (MS)

Who this might be right for
Multiple Sclerosis
Eva M.M. Strijbis 75
Testing effectiveness (Phase 2)UnknownNCT01466114
What this trial is testing

Estriol Treatment in Multiple Sclerosis (MS): Effect on Cognition

Who this might be right for
Relapsing-remitting Multiple SclerosisSecondary-progressive Multiple SclerosisPrimary-progressive Multiple Sclerosis
University of California, Los Angeles 64
Testing effectiveness (Phase 2)Study completedNCT02988401
What this trial is testing

Intranasal Insulin for Improving Cognitive Function in Multiple Sclerosis

Who this might be right for
Multiple Sclerosis, Relapsing-RemittingMultiple Sclerosis, Secondary ProgressiveMultiple Sclerosis, Primary Progressive
Johns Hopkins University 105
Not applicableUnknownNCT03787446
What this trial is testing

PET Study in Multiple Sclerosis

Who this might be right for
Multiple Sclerosis
University of British Columbia 9
Not applicableStudy completedNCT03455582
What this trial is testing

Cognition Evolution and MRI Markers in PPMS Patients on 2 Years

Who this might be right for
Multiple Sclerosis, Primary Progressive
University Hospital, Bordeaux 66
Next Page