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Results for “Programmed Cell Death 1”

393 trials

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Showing 20 of 393 results

Testing effectiveness (Phase 2)Study completedNCT04361331
What this trial is testing

Two-cohort Study of Toripalimab(PD1)+Lenvatnib, or Gemox+Lenvatinib in Advanced Intrahepatic Cholangiocarcinoma

Who this might be right for
Cholangiocarcinoma, Intrahepatic
Shanghai Zhongshan Hospital 61
Large-scale testing (Phase 3)Study completedNCT02494583
What this trial is testing

Study of Pembrolizumab (MK-3475) as First-Line Monotherapy and Combination Therapy for Treatment of Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (MK-3475-062/KEYNOTE-062)

Who this might be right for
Gastric Adenocarcinoma
Merck Sharp & Dohme LLC 763
Not applicableUnknownNCT05964595
What this trial is testing

Temporal Diffusion Spectroscopy MRI in Predicting the CPS of PD-L1 Expression and the Efficacy of Neoadjuvant Therapy

Who this might be right for
Head and Neck Squamous Cell CarcinomaMagnetic Resonance ImagingNeoadjuvant Therapy
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University 136
Early research (Phase 1)Study completedNCT05017012
What this trial is testing

Evaluate the Bioavailability of Pembrolizumab (MK-3475) Via Subcutaneous (SC) Injection of Pembrolizumab Formulated With Berahyaluronidase Alfa (MK-5180) [MK-3475A] In Advanced Solid Tumors (MK-3475A-C18)

Who this might be right for
Advanced or Metastatic Solid Tumors
Merck Sharp & Dohme LLC 142
Testing effectiveness (Phase 2)Active Not RecruitingNCT06483334
What this trial is testing

Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)

Who this might be right for
Metastatic Urothelial CarcinomaLocally Advanced Urothelial Carcinoma
Merck Sharp & Dohme LLC 38
Large-scale testing (Phase 3)Study completedNCT02256436
What this trial is testing

Pembrolizumab (MK-3475) Versus Paclitaxel, Docetaxel, or Vinflunine for Participants With Advanced Urothelial Cancer (MK-3475-045/KEYNOTE-045)

Who this might be right for
Urothelial Cancer
Merck Sharp & Dohme LLC 542
Testing effectiveness (Phase 2)Study completedNCT03516981
What this trial is testing

Biomarker-Directed, Pembrolizumab (MK-3475) Based Combination Therapy for Advanced Non-Small Cell Lung Cancer (MK-3475-495/KEYNOTE-495)

Who this might be right for
Advanced Non-Small Cell Lung Cancer
Merck Sharp & Dohme LLC 245
Early research (Phase 1)Study completedNCT03111992
What this trial is testing

Study of Single Agent CJM112, and PDR001 in Combination With LCL161 or CJM112 in Patients With Multiple Myeloma

Who this might be right for
Multiple Myeloma
Novartis Pharmaceuticals 26
Testing effectiveness (Phase 2)Looking for participantsNCT07111520
What this trial is testing

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

Who this might be right for
Non-small Cell Lung Cancer
BioNTech SE 880
Large-scale testing (Phase 3)Study completedNCT03875092
What this trial is testing

Carboplatin-Paclitaxel/Nab-Paclitaxel Chemotherapy With or Without Pembrolizumab (MK-3475) in Adults With First Line Metastatic Squamous Non-small Cell Lung Cancer (MK-3475-407/KEYNOTE-407)-China Extension Study

Who this might be right for
Non-small Cell Lung Cancer
Merck Sharp & Dohme LLC 125
Testing effectiveness (Phase 2)UnknownNCT03263039
What this trial is testing

Biomarkers in Urothelial Cancer Patients Treated With Pembrolizumab

Who this might be right for
Transitional Cell Carcinoma of the BladderBiomarkers
Erasmus Medical Center 80
Not applicableActive Not RecruitingNCT07024862
What this trial is testing

Long-term Outcomes Among Patients With Programmed Death-ligand 1 <1% Metastatic Non-small Cell Lung Cancer Treated With First-line Nivolumab + Ipilimumab + 2 Cycles of Chemotherapy

Who this might be right for
Metastatic Non-small Cell Lung Cancer
Bristol-Myers Squibb 100
Testing effectiveness (Phase 2)UnknownNCT05281003
What this trial is testing

Pembrolizumab Plus Chemo in Neoadjuvant Treatment of Esophageal Squamous Cell Carcinoma (Eastern Cooperative Thoracic Oncology Projects 2004, ECTOP-2004)

Who this might be right for
Esophageal Squamous Cell Carcinoma
Fudan University 128
Not applicableLooking for participantsNCT06772454
What this trial is testing

To Evaluate the Efficacy and Safety of Inhaled Corticosteroids Combined With Bronchodilators and Programmed Death-ligand 1 (PD-L1) Inhibitor Plus Platinum-based Chemotherapy in Patients With Advanced Lung Squamous Cell Carcinoma Complicated With Chronic Obstructive Pulmonary Disease (COPD)

Who this might be right for
Lung Cancer Squamous CellCOPD
Guangzhou Institute of Respiratory Disease 60
Early research (Phase 1)Study completedNCT03003676
What this trial is testing

A Pilot Study of Sequential ONCOS-102, an Engineered Oncolytic Adenovirus Expressing GMCSF, and Pembrolizumab in Patients With Advanced or Unresectable Melanoma Progressing After Programmed Cell Death Protein 1 (PD1) Blockade

Who this might be right for
Advanced or Unresectable Melanoma Progressing After PD1 Blockade
Targovax Oy 21
Large-scale testing (Phase 3)Looking for participantsNCT06712355
What this trial is testing

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

Who this might be right for
Extensive-stage Small-cell Lung Cancer
BioNTech SE 621
Early research (Phase 1)Study completedNCT04223804
What this trial is testing

Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of ABBV-181 (Budigalimab) in Adult Participants With Human Immunodeficiency Virus (HIV)-1

Who this might be right for
Human Immunodeficiency Virus (HIV)HIV InfectionHIV-1
AbbVie 41
Large-scale testing (Phase 3)Active Not RecruitingNCT06472076
What this trial is testing

Belrestotug Plus Dostarlimab Compared With Placebo Plus Pembrolizumab in Previously Untreated Participants With Programmed Death Ligand 1 (PD-L1) High Non-small-cell Lung Cancer (NSCLC)

Who this might be right for
Lung Cancer, Non-Small Cell
GlaxoSmithKline 88
Very early researchLooking for participantsNCT06305962
What this trial is testing

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

Who this might be right for
PDL1 Gene MutationNon Small Cell Lung CancerSmall Cell Lung Cancer ( SCLC )+6 more
Radiopharm Theranostics, Ltd 30
Testing effectiveness (Phase 2)Study completedNCT04669899
What this trial is testing

Study of JTX-8064, as Monotherapy and in Combination With a PD-1 Inhibitor, in Adult Subjects With Advanced Refractory Solid Tumors

Who this might be right for
Cancer
Jounce Therapeutics, Inc. 190
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