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Results for “Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor”

85 trials

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Showing 20 of 85 results

Testing effectiveness (Phase 2)UnknownNCT06304987
What this trial is testing

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and PCSK9 Inhibitor for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer
Beijing Friendship Hospital 50
Not applicableNot Yet RecruitingNCT06730802
What this trial is testing

Protective Effect of PCSK9 Inhibitor Against Negative Inflammatory Response and Organ Dysfunction After Coronary Artery Bypass Grafting (PANDA VIII)

Who this might be right for
Myocardial Ischaemic SyndromeCoronary Heart Disease
Nanjing Medical University 400
Testing effectiveness (Phase 2)Active Not RecruitingNCT06933251
What this trial is testing

PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy for pMMR/MSS Locally Advanced Rectal Cancer

Who this might be right for
Locally Advanced Rectal Cancer (LARC)
Guangdong Provincial People's Hospital 30
Not applicableUnknownNCT05043740
What this trial is testing

PCSK9 Inhibitor on ACS Patients With Multivessel Disease and Relatively Low LDL-C Level in Chinese Population

Who this might be right for
Acute Coronary Syndrome
Second Xiangya Hospital of Central South University 1,360
Post-approval studies (Phase 4)UnknownNCT04100434
What this trial is testing

Effect of Evolocumab Added to Moderate-Intensity Statin Therapy on LDL-C Lowering and Cardiovascular Adverse Events in Patients With Acute Coronary Syndrome

Who this might be right for
Acute Coronary SyndromeProprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
Tianjin Chest Hospital 500
Post-approval studies (Phase 4)Study completedNCT03096288
What this trial is testing

Impact of Evolocumab on the Effects of Clopidogrel in Patients With High On-Treatment Platelet Reactivity

Who this might be right for
Atherosclerotic Cardiovascular Disease
University of Florida 259
Large-scale testing (Phase 3)Active Not RecruitingNCT05360446
What this trial is testing

Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events

Who this might be right for
Coronary Artery Disease
Novartis Pharmaceuticals 608
Large-scale testing (Phase 3)Study completedNCT06450366
What this trial is testing

Evaluate the Efficacy and Safety of Enlicitide (MK-0616, Oral PCSK9 Inhibitor) Compared With Ezetimibe or Bempedoic Acid or Ezetimibe and Bempedoic Acid in Adults With Hypercholesterolemia (MK-0616-018/CORALreef AddOn)

Who this might be right for
Hypercholesterolemia
Merck Sharp & Dohme LLC 301
Very early researchNot Yet RecruitingNCT06996223
What this trial is testing

A Multicenter, Prospective, Randomized Controlled Trial to Evaluate the Efficacy of PCSK-9 Inhibitors in Delaying the Progression of Calcified Aortic Valve Disease

Who this might be right for
Aortic StenosisPCSK9 InhibitorCalcified Aortic Valve Disease
Nanfang Hospital, Southern Medical University 316
Testing effectiveness (Phase 2)Looking for participantsNCT07468630
What this trial is testing

Tolecizumab Plus Chemoimmunotherapy for pMMR/MSS Locally Advanced Colon Adenocarcinoma

Who this might be right for
Colon Adenocarcinoma
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University 106
Post-approval studies (Phase 4)Study completedNCT07295366
What this trial is testing

Early Administration of PCSK9 Inhibitors After Thrombectomy for Atherosclerotic Acute Ischemic Stroke: A Randomized Controlled Trial

Who this might be right for
Acute Stroke
The Affiliated Hospital of Xuzhou Medical University 60
Not applicableLooking for participantsNCT06738758
What this trial is testing

Multicenter Real-World Cohort Study Evaluating the Impact of Early Intensive Lipid-Lowering Therapy on the Prognosis of Acute Coronary Syndrome Patients(ELITE-ACS)

Who this might be right for
Acute Coronary Syndromes
Yun Dai Chen 6,000
Not applicableLooking for participantsNCT05765370
What this trial is testing

LDL Cholesterol TARGETs in OLDer Patients (Age≥75 Years) With ASCVD (TARGET OLD)

Who this might be right for
Atherosclerotic Cardiovascular DiseaseOlder PatientsLDL Cholesterol
China National Center for Cardiovascular Diseases 4,200
Post-approval studies (Phase 4)Not Yet RecruitingNCT07036991
What this trial is testing

Clinical Trial of PCSK9 Inhibitor and Statin Treatment for Carotid Artery Stenosis

Who this might be right for
Carotid Artery Stenosis
Changhai Hospital 406
Testing effectiveness (Phase 2)Active Not RecruitingNCT05001984
What this trial is testing

Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis

Who this might be right for
Intracranial AtherosclerosisAcute Ischemic StrokeICAS - Intracranial Atherosclerosis
Chang Gung Memorial Hospital 60
Not applicableUnknownNCT06134635
What this trial is testing

Short-term Effect of PCSK9 Inhibitor in Patients With Acute Ischemic Stroke

Who this might be right for
Acute Ischemic Stroke
Xuanwu Hospital, Beijing 80
Not applicableUnknownNCT06364124
What this trial is testing

Effects of PCSK-9 Inhibitor Treatment Prior to Undergoing Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction

Who this might be right for
STEMI
Beijing Luhe Hospital 84
Not applicableStudy completedNCT03273972
What this trial is testing

INvestigating the Lowest Threshold of Vascular bENefits From LDL Lowering With a PCSK9 InhibiTor in healthY Volunteers

Who this might be right for
AtherosclerosisCardiovascular Diseases
Cambridge University Hospitals NHS Foundation Trust 30
Not applicableNot Yet RecruitingNCT07341958
What this trial is testing

INtensive liPid-lowering Therapy for Acute High-risk IntracRanial or Extracranial atheroSclerosis -II (INSPIRES-2)

Who this might be right for
Ischemic Stroke or High-risk TIA (ABCD² ≥ 4)
Beijing Tiantan Hospital 242
Post-approval studies (Phase 4)Looking for participantsNCT05292404
What this trial is testing

Impact of Early PCSK9 Inhibitor Treatment on Heart After Acute Myocardium Infarction

Who this might be right for
Acute Myocardial Infarction
Shanghai Tong Ren Hospital 160
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