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Results for “Protein Kinases”

274 trials

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Showing 20 of 274 results

Testing effectiveness (Phase 2)Looking for participantsNCT06411821
What this trial is testing

Ulixertinib in People With Histiocytic Neoplasms

Who this might be right for
Histiocytic Neoplasms
Memorial Sloan Kettering Cancer Center 38
Early research (Phase 1)Study completedNCT02211014
What this trial is testing

An Open-Label, Phase 1b Study of Acalabrutinib With and Without Dexamethasone in Subjects With Multiple Myeloma

Who this might be right for
Multiple Myeloma (MM)
Acerta Pharma BV 27
Testing effectiveness (Phase 2)UnknownNCT06098872
What this trial is testing

Pilot Study on Trametinib for Surgical Unruptured AVMs

Who this might be right for
Arteriovenous Malformations
University Health Network, Toronto 10
Early research (Phase 1)Study completedNCT04959981
What this trial is testing

Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLC

Who this might be right for
Advanced Non-squamous Non-small-cell Lung Cancer
Erasca, Inc. 24
Not applicableUnknownNCT05460312
What this trial is testing

Protein Kinase A in Prostate Cancer Tissue.

Who this might be right for
Prostate NeoplasmInflammationBenign Hyperplasia of Prostate
Ziv Hospital 100
Testing effectiveness (Phase 2)Study completedNCT04062448
What this trial is testing

Ibrutinib in Combination With Rituximab, in Japanese Participants With Waldenstrom's Macroglobulinemia (WM)

Who this might be right for
Waldenstrom Macroglobulinemia
Janssen Pharmaceutical K.K. 16
Early research (Phase 1)Study completedNCT01585701
What this trial is testing

Phase I Study of AT13148, a Novel AGC Kinase Inhibitor

Who this might be right for
Advanced Solid Tumours
Cancer Research UK 56
Testing effectiveness (Phase 2)Ended earlyNCT00445549
What this trial is testing

Vandetanib to Treat Women With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Who this might be right for
Ovarian NeoplasmsFallopian Tube NeoplasmsPeritoneal Neoplasms
National Cancer Institute (NCI) 12
Large-scale testing (Phase 3)Study completedNCT01535391
What this trial is testing

Nilotinib in PH+, BCR-, ABL+ CML Patients

Who this might be right for
Chronic Myeloid Leukemia
Gruppo Italiano Malattie EMatologiche dell'Adulto 109
Testing effectiveness (Phase 2)Active Not RecruitingNCT03162536
What this trial is testing

Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

Who this might be right for
Lymphoma, B-CellSmall Lymphocytic LymphomaChronic Lymphocytic Leukemia+6 more
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) 190
Testing effectiveness (Phase 2)Study completedNCT00639002
What this trial is testing

Determine the Effect and Safety of an Oral Janus Kinase 2 (JAK2)-Inhibitor (Ruxolitinib; INBC018424) in Patients With Multiple Myeloma

Who this might be right for
Multiple Myeloma
Incyte Corporation 13
Large-scale testing (Phase 3)Active Not RecruitingNCT02201992
What this trial is testing

Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial)

Who this might be right for
ALK Gene RearrangementALK Gene TranslocationALK Positive+5 more
ECOG-ACRIN Cancer Research Group 166
Early research (Phase 1)Study completedNCT02516813
What this trial is testing

Phase 1 Trial of MSC2490484A, an Inhibitor of a DNA-dependent Protein Kinase, in Combination With Radiotherapy

Who this might be right for
Advanced Solid Tumors
EMD Serono Research & Development Institute, Inc. 52
Early research (Phase 1)Ended earlyNCT03182673
What this trial is testing

The Study of SHR7390 in Combination With SHR-1210 and SHR3162 in Patients With Advanced Solid Tumors

Who this might be right for
Solid Tumor
Jiangsu HengRui Medicine Co., Ltd. 31
Not applicableUnknownNCT02635269
What this trial is testing

Fat and Sugar Metabolism During Exercise in Patients With Metabolic Myopathy

Who this might be right for
Metabolism, Inborn ErrorsLipid Metabolism, Inborn ErrorsCarbohydrate Metabolism, Inborn Errors+20 more
Rigshospitalet, Denmark 60
Early research (Phase 1)Ended earlyNCT05153408
What this trial is testing

(HARMONY) Study of BLU-701 in EGFR-mutant NSCLC

Who this might be right for
Lung NeoplasmCarcinoma, Non-Small-Cell LungRespiratory Tract Neoplasms+24 more
Blueprint Medicines Corporation 20
Not applicableLooking for participantsNCT06092346
What this trial is testing

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Who this might be right for
AMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase DeficiencyAMPD1, OMIM *102770, Myopathy Due to Myoadenylate Deaminase Deficiency+25 more
National Human Genome Research Institute (NHGRI)
Early research (Phase 1)Study completedNCT04712396
What this trial is testing

Assess How Itraconazole Affects the Uptake and Elimination of Capivasertib in the Body

Who this might be right for
Healthy Volunteers (Intended Indication: Metastatic Patients With Triple Negative or HR+ Breast Cancer, or Hormone Sensitive Prostate Cancer)
AstraZeneca 11
Testing effectiveness (Phase 2)Study completedNCT02530320
What this trial is testing

Safety and Efficacy of PD0332991 (Palbociclib), a Cyclin-dependent Kinase 4 and 6 Inhibitor, in Patients With Oligodendroglioma or Recurrent Oligoastrocytoma Anaplastic With the Activity of the Protein RB Preserved

Who this might be right for
OligodendrogliomaOligoastrocytoma
Grupo Español de Investigación en Neurooncología 34
Not applicableStudy completedNCT02824159
What this trial is testing

Association Between Side Effects Occurrence and Concentrations of Ibrutinib and Idelalisib

Who this might be right for
Hematological Malignancies
University Hospital, Toulouse 121
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