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Results for “RAS-mutated”

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Showing 20 of 0 results

Testing effectiveness (Phase 2)Study completedNCT05340621
What this trial is testing

NAUTILUS: OKI-179 Plus Binimetinib in Patients with Advanced Solid Tumors in the RAS Pathway (Phase 1b) and NRAS-mutated Melanoma (Phase 2)

Who this might be right for
RAS MutationNRAS Gene MutationMelanoma
OnKure, Inc. 36
Large-scale testing (Phase 3)Looking for participantsNCT06881784
What this trial is testing

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Who this might be right for
NSCLC (Non-small Cell Lung Cancer)Non-Small Cell Lung CancerNSCLC+2 more
Revolution Medicines, Inc. 590
Testing effectiveness (Phase 2)Study completedNCT02448290
What this trial is testing

Single-arm Study of Selumetinib in Combination With Docetaxel, in Advanced Gastric Adenocarcinoma Patients With Low/High MEK Signature, RAS Mutation or RAS Amplification as a Second-line Chemotherapy

Who this might be right for
Gastric Adenocarcinoma
Samsung Medical Center 25
Testing effectiveness (Phase 2)Ended earlyNCT03745326
What this trial is testing

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients

Who this might be right for
Gastrointestinal CancerPancreatic CancerGastric Cancer+2 more
National Cancer Institute (NCI) 5
Testing effectiveness (Phase 2)Study completedNCT01450319
What this trial is testing

Cetuximab in Refractory Colorectal Cancer With K-RAS Mutated and Favorable FcγRIIa (CD32) Genotype

Who this might be right for
Colorectal Neoplasms
Merck KGaA, Darmstadt, Germany 73
Large-scale testing (Phase 3)Active Not RecruitingNCT05171660
What this trial is testing

Combination With Sintilimab and XELOX+Bevacizumab as 1st Line Therapy in RAS-mutant Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Stage IV
Second Affiliated Hospital, Zhejiang University, School of Medicine 446
Testing effectiveness (Phase 2)Study completedNCT02414009
What this trial is testing

Study to Compare CAPTEM vs FOLFIRI as Second Line Treatment in Advanced, Colorectal Cancer Patients

Who this might be right for
Metastatic Colorectal Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 82
Testing effectiveness (Phase 2)Study completedNCT01298570
What this trial is testing

Regorafenib+FOLFIRI Versus Placebo+FOLFIRI as 2nd Line Tx in Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
UNC Lineberger Comprehensive Cancer Center 181
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Testing effectiveness (Phase 2)Study completedNCT05593328
What this trial is testing

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

Who this might be right for
Colorectal CancerMetastatic Colorectal Cancer
Cardiff Oncology 23
Testing effectiveness (Phase 2)Study completedNCT01693068
What this trial is testing

Phase II Trial of Pimasertib Versus Dacarbazine in N-Ras Mutated Cutaneous Melanoma

Who this might be right for
N-Ras Mutated Locally Advanced or Metastasis Malignant Cutaneous Melanoma
EMD Serono 194
Testing effectiveness (Phase 2)Looking for participantsNCT07213570
What this trial is testing

STREAM-2: Second-line Treatment With REgorafenib in Advanced RAS-Mutant Colorectal Cancer

Who this might be right for
Colorectal Cancer Metastatic
National Cancer Institute, Naples 60
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07797244
What this trial is testing

A Single-Arm, Phase II Study of Retlirafusp Alfa in Combination With XELOX and Bevacizumab for the First-Line Treatment of Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM)

Who this might be right for
Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM)
Dai, Guanghai 46
Not applicableLooking for participantsNCT04395495
What this trial is testing

RASopathy Biorepository

Who this might be right for
RAS MutationNeurofibromatosis 1Noonan Syndrome+11 more
Children's Hospital Medical Center, Cincinnati 1,000
Early research (Phase 1)Looking for participantsNCT04678648
What this trial is testing

A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

Who this might be right for
Advanced Malignant Solid NeoplasmRAS MutationLung Cancer+3 more
RasCal Therapeutics, Inc. 134
Large-scale testing (Phase 3)Active Not RecruitingNCT04793958
What this trial is testing

Phase 3 Study of MRTX849 With Cetuximab vs Chemotherapy in Patients With Advanced Colorectal Cancer With KRAS G12C Mutation (KRYSTAL-10)

Who this might be right for
Advanced Colorectal CancerMetastatic Colorectal Cancer
Mirati Therapeutics Inc. 461
Early research (Phase 1)Looking for participantsNCT06884618
What this trial is testing

Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

Who this might be right for
Neoplasms
Hoffmann-La Roche 405
Early research (Phase 1)Ended earlyNCT07121829
What this trial is testing

Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid Tumors

Who this might be right for
MelanomaSolid TumorPilocytic Astrocytoma+7 more
Day One Biopharmaceuticals, Inc. 44
Testing effectiveness (Phase 2)Looking for participantsNCT07020221
What this trial is testing

VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

Who this might be right for
Pancreatic Ductal AdenocarcinomaNon Small Cell Lung CancerColorectal Cancer+2 more
Verastem, Inc. 295
Testing effectiveness (Phase 2)Looking for participantsNCT06321081
What this trial is testing

ICE Study: Combination of Irinotecan Plus Cetuximab and Envafolimab as a Rechallenge Regimen in mCRC

Who this might be right for
RAS MutationMetastatic Colorectal CancerMSS
Beijing Hospital 60
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