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Results for “Receptors, Fibroblast Growth Factor”

72 trials

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Showing 20 of 72 results

Early research (Phase 1)Study completedNCT01703481
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Adult Participants With Advanced or Refractory Solid Tumors or Lymphoma

Who this might be right for
Tumor or Lymphoma
Janssen Research & Development, LLC 188
Early research (Phase 1)Looking for participantsNCT06625593
What this trial is testing

A First-in-Human (FIH) Study of BG-C137, an Anti-Fibroblast Growth Factor Receptor 2b (FGFR2b) Antibody Drug Conjugate, in Participants With Advanced Solid Tumors

Who this might be right for
Advanced Solid Tumor
BeOne Medicines 168
Early research (Phase 1)Looking for participantsNCT06160752
What this trial is testing

Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

Who this might be right for
Locally Advanced CholangiocarcinomaIntrahepatic CholangiocarcinomaSolid Tumor+1 more
Tyra Biosciences, Inc 40
Early research (Phase 1)Study completedNCT01962532
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Patients With Advanced or Refractory Solid Tumors or Lymphoma

Who this might be right for
NeoplasmsLymphomaAdenocarcinoma+1 more
Janssen Research & Development, LLC 19
Not applicableLooking for participantsNCT06410976
What this trial is testing

Prospective Clinical Assessment Study in Children With Hypochondroplasia

Who this might be right for
Hypochondroplasia
QED Therapeutics, a BridgeBio company 150
Testing effectiveness (Phase 2)Study completedNCT03797326
What this trial is testing

Efficacy and Safety of Pembrolizumab (MK-3475) Plus Lenvatinib (E7080/MK-7902) in Previously Treated Participants With Select Solid Tumors (MK-7902-005/E7080-G000-224/LEAP-005)

Who this might be right for
Advanced Solid TumorsTriple Negative Breast CancerOvarian Cancer+5 more
Merck Sharp & Dohme LLC 611
Early research (Phase 1)Ended earlyNCT03144661
What this trial is testing

An Open-Label Safety and Tolerability Study of INCB062079 in Subjects With Advanced Hepatocellular Carcinoma and Other Malignancies

Who this might be right for
Hepatocellular Carcinoma (HCC)CholangiocarcinomaEsophageal Cancer+3 more
Incyte Corporation 25
Not applicableStudy completedNCT04035811
What this trial is testing

Prospective Clinical Assessment Study in Children With Achondroplasia (ACH)

Who this might be right for
Achondroplasia
QED Therapeutics, a BridgeBio company 271
Not applicableStudy completedNCT03955913
What this trial is testing

Identify Participants With Urothelial Cancer and Fibroblast Growth Factor Receptor Gene Aberrations

Who this might be right for
Urothelial CancerReceptors, Fibroblast Growth Factor
Janssen Research & Development, LLC 3,679
Early research (Phase 1)Study completedNCT01976741
What this trial is testing

Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor (Rogaratinib)

Who this might be right for
Neoplasms
Bayer 168
Testing effectiveness (Phase 2)Looking for participantsNCT07292168
What this trial is testing

A Phase 1b/2 Study of the Safety and Efficacy of the Monoclonal Antibody OM-RCA-01 in Patients With Metastatic Tumors Expressing Fibroblast Growth Factor Receptor 1

Who this might be right for
Renal Cell Carcinoma MetastaticProstate Cancer MetastaticNon-small Cell Lung Cancer Metastatic+2 more
Kidney Cancer Research Bureau 58
Testing effectiveness (Phase 2)Study completedNCT02421185
What this trial is testing

Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 (Erdafitinib) in Participants With Advanced Hepatocellular Carcinoma

Who this might be right for
Carcinoma, Hepatocellular
Janssen Research & Development, LLC 53
Large-scale testing (Phase 3)Active Not RecruitingNCT05052801
What this trial is testing

Bemarituzumab or Placebo Plus Chemotherapy in Gastric Cancers With Fibroblast Growth Factor Receptor 2b (FGFR2b) Overexpression

Who this might be right for
Gastric CancerGastroesophageal Junction Adenocarcinoma
Amgen 547
Testing effectiveness (Phase 2)Enrolling By InvitationNCT07393373
What this trial is testing

Open-Label, Long-Term, Extension Study of Infigratinib in Children With Hypochondroplasia

Who this might be right for
Hypochondroplasia
QED Therapeutics, a BridgeBio company 135
Testing effectiveness (Phase 2)Enrolling By InvitationNCT05145010
What this trial is testing

Extension Study of Infigratinib in Children With Achondroplasia (ACH)

Who this might be right for
Achondroplasia
QED Therapeutics, a BridgeBio company 300
Early research (Phase 1)Ended earlyNCT02368951
What this trial is testing

Phase I, Dose-escalation Trial of BAY1187982 in Subjects With Advanced Solid Tumors Known to Express Fibroblast Growth Factor Receptor 2 (FGFR2)

Who this might be right for
Medical Oncology
Bayer 20
Testing effectiveness (Phase 2)Study completedNCT01676714
What this trial is testing

Study of Dovitinib and Biomarkers in Advanced Non-Small Cell Lung Cancer or Advanced Colorectal Cancer

Who this might be right for
Non-Small Cell Lung CancerColorectal Cancer
University of California, Davis 10
Testing effectiveness (Phase 2)Ended earlyNCT01367275
What this trial is testing

Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated Levels of Plasma FGF

Who this might be right for
Colorectal CancerColorectal Adenocarcinoma
M.D. Anderson Cancer Center 8
Early research (Phase 1)Study completedNCT02038673
What this trial is testing

An Open-label Phase I Study of Orally Available Novel Small-molecule Fibroblast Growth Factor Receptors (FGFR) 1,2,3 and 4 Inhibitor, ASP5878 at Single and Multiple Doses in Patients With Solid Tumors

Who this might be right for
Solid Tumors
Astellas Pharma Inc 86
Testing effectiveness (Phase 2)Study completedNCT04045613
What this trial is testing

Derazantinib and Atezolizumab in Patients With Urothelial Cancer

Who this might be right for
Urothelial Carcinoma
Basilea Pharmaceutica 95
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