Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Recurrent Metastatic Malignant Neoplasm in the Leptomeninges”

25 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 25 results

Early research (Phase 1)Study completedNCT00006246
What this trial is testing

Busulfan in Treating Children and Adolescents With Refractory CNS Cancer

Who this might be right for
Brain and Central Nervous System TumorsChildhood Germ Cell TumorLeukemia+4 more
Pediatric Brain Tumor Consortium 28
Early research (Phase 1)Ended earlyNCT00112619
What this trial is testing

Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia, Lymphoma, or Solid Tumors

Who this might be right for
Brain and Central Nervous System TumorsCarcinoma of Unknown PrimaryLeukemia+2 more
Pediatric Brain Tumor Consortium 19
Early research (Phase 1)Active Not RecruitingNCT03696030
What this trial is testing

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Who this might be right for
Malignant NeoplasmMetastatic Malignant Neoplasm in the BrainMetastatic Malignant Neoplasm in the Leptomeninges+2 more
City of Hope Medical Center 24
Early research (Phase 1)Study completedNCT00025311
What this trial is testing

Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain

Who this might be right for
Brain and Central Nervous System Tumors
NYU Langone Health
Early research (Phase 1)Ended earlyNCT00512460
What this trial is testing

RTA 744 Injection in Patients With Leptomeningeal Disease

Who this might be right for
Neoplastic MeningitisSolid TumorLymphoma+2 more
M.D. Anderson Cancer Center 7
Testing effectiveness (Phase 2)Study completedNCT00450866
What this trial is testing

Epothilone B in Treating Patients With CNS Metastases From Breast Cancer

Who this might be right for
Breast CancerMetastatic Cancer
David Peereboom, MD 55
Early research (Phase 1)Study completedNCT00002750
What this trial is testing

Melphalan in Patients With Neoplastic Meningitis

Who this might be right for
Brain and Central Nervous System TumorsExtragonadal Germ Cell TumorLeukemia+2 more
Duke University 6
Testing effectiveness (Phase 2)Looking for participantsNCT07264569
What this trial is testing

Evaluate the Safety, Tolerability, Biodistribution Characteristics and Preliminary Efficacy of BioTTT001

Who this might be right for
Meningeal Metastasis
Henan Cancer Hospital 42
Testing effectiveness (Phase 2)Study completedNCT00992602
What this trial is testing

Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer

Who this might be right for
Central Nervous System MetastasesLeptomeningeal MetastasesRecurrent Breast Cancer+2 more
University of Washington 3
Early research (Phase 1)Study completedNCT00005842
What this trial is testing

Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer

Who this might be right for
Cancer
National Cancer Institute (NCI) 24
Early research (Phase 1)Active Not RecruitingNCT04250545
What this trial is testing

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

Who this might be right for
Leptomeningeal NeoplasmMetastatic Lung Non-Small Cell CarcinomaMetastatic Malignant Neoplasm in the Brain+4 more
National Cancer Institute (NCI) 22
Very early researchStudy completedNCT00424242
What this trial is testing

Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal Metastases

Who this might be right for
Brain and Central Nervous System TumorsChronic Myeloproliferative DisordersLeukemia+8 more
Northwestern University 15
Early research (Phase 1)Active Not RecruitingNCT04661384
What this trial is testing

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

Who this might be right for
EpendymomaGlioblastomaMedulloblastoma+1 more
City of Hope Medical Center 10
Not applicableUnknownNCT04778800
What this trial is testing

A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)

Who this might be right for
NSCLCBrain MetastasesLeptomeningeal Metastasis
Henan Cancer Hospital 60
Early research (Phase 1)Study completedNCT03101579
What this trial is testing

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

Who this might be right for
Leptomeningeal Metastases
The First Hospital of Jilin University 13
Early research (Phase 1)Study completedNCT02423525
What this trial is testing

Safety Study of Afatinib for Brain Cancer

Who this might be right for
Brain Cancer
Santosh Kesari 24
Early research (Phase 1)UnknownNCT00003073
What this trial is testing

Chemotherapy in Treating Young Patients With Recurrent or Refractory Meningeal Leukemia, Lymphoma, or Solid Tumors

Who this might be right for
Brain and Central Nervous System TumorsLeukemiaLymphoma+1 more
Pacira Pharmaceuticals, Inc 15
Early research (Phase 1)Study completedNCT00416923
What this trial is testing

Intrathecal Rituximab in Treating Patients With Recurrent CNS Lymphoma

Who this might be right for
Brain and Central Nervous System TumorsLymphoma
University of California, San Francisco 10
Early research (Phase 1)Ended earlyNCT00527410
What this trial is testing

A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis

Who this might be right for
Leptomeningeal Carcinomatosis
Biogen 9
Testing effectiveness (Phase 2)Study completedNCT00005811
What this trial is testing

Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment

Who this might be right for
AIDS-related Diffuse Large Cell LymphomaAIDS-related Diffuse Mixed Cell LymphomaAIDS-related Diffuse Small Cleaved Cell Lymphoma+17 more
National Cancer Institute (NCI) 77
Load More Results