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Results for “Refractory Langerhans Cell Histiocytosis”

45 trials

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Showing 20 of 45 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT03213652
What this trial is testing

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmMalignant Solid NeoplasmRecurrent Ependymoma+30 more
National Cancer Institute (NCI) 13
Testing effectiveness (Phase 2)UnknownNCT04405375
What this trial is testing

GPED Regimen for Relapsed/Refractory or Advanced ENKTCL

Who this might be right for
Extranodal NK/T-cell Lymphoma, Nasal Type
Beijing Tongren Hospital 29
Testing effectiveness (Phase 2)UnknownNCT00008164
What this trial is testing

Umbilical Cord Blood and Placental Blood Transplantation in Treating Patients With Hematologic Cancer or Aplastic Anemia

Who this might be right for
Childhood Langerhans Cell HistiocytosisLeukemiaLymphoma+3 more
Herbert Irving Comprehensive Cancer Center 30
Testing effectiveness (Phase 2)Looking for participantsNCT07022834
What this trial is testing

Real-world Study of Darafenib or Trametinib and Clofarabine for High-risk/Recurrent/Refractory Langerhans Cell Histiocytosis in Children

Who this might be right for
Langerhans Cell Histiocytosis (LCH)
West China Second University Hospital 20
Testing effectiveness (Phase 2)Looking for participantsNCT04943224
What this trial is testing

Optimization of the Time and Dosage of Trametinib in BRAF Negative Juvenile Patients

Who this might be right for
Histiocytosis
Anna Raciborska 12
Large-scale testing (Phase 3)UnknownNCT03533790
What this trial is testing

DEP-Ru Regimen as a Salvage Therapy for HLH

Who this might be right for
Hemophagocytic Lymphohistiocytosis
Beijing Friendship Hospital 80
Testing effectiveness (Phase 2)Active Not RecruitingNCT03213704
What this trial is testing

Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmRecurrent EpendymomaRecurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor+30 more
National Cancer Institute (NCI) 9
Testing effectiveness (Phase 2)Active Not RecruitingNCT04284774
What this trial is testing

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

Who this might be right for
Malignant Solid NeoplasmRecurrent Adrenal Gland PheochromocytomaRecurrent Ectomesenchymoma+38 more
National Cancer Institute (NCI) 5
Testing effectiveness (Phase 2)Study completedNCT03213678
What this trial is testing

Samotolisib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmAnn Arbor Stage III Non-Hodgkin LymphomaAnn Arbor Stage IV Non-Hodgkin Lymphoma+30 more
National Cancer Institute (NCI) 18
Not applicableEnded earlyNCT00008216
What this trial is testing

Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer

Who this might be right for
Adult Langerhans Cell HistiocytosisChildhood Langerhans Cell HistiocytosisLeukemia+4 more
Columbia University 48
Testing effectiveness (Phase 2)Looking for participantsNCT04943198
What this trial is testing

Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis

Who this might be right for
Histiocytosis
Anna Raciborska 25
Early research (Phase 1)Active Not RecruitingNCT00710892
What this trial is testing

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

Who this might be right for
Acute Lymphoblastic LeukemiaNon-Hodgkin's LymphomaMyelodysplastic Syndrome+1 more
Baylor College of Medicine 10
Early research (Phase 1)Enrolling By InvitationNCT06902792
What this trial is testing

Adebrelimab Combined With Trametinib in the Treatment of Refractory Recurrent Langerhans Cell Histiocytosis in Children and Adolescents

Who this might be right for
Histiocytosis, Langerhans-Cell
Second Affiliated Hospital of Wenzhou Medical University 6
Not applicableEnded earlyNCT01547143
What this trial is testing

Pilot Study of Etoposide-based Therapy and Hematopoietic Cell Transplantation for Hemophagocytic Lymphohistiocytosis

Who this might be right for
Hemophagocytic Lymphohistiocytosis
Asan Medical Center 12
Early research (Phase 1)UnknownNCT05477446
What this trial is testing

Safety and Efficacy of CD207 Targeted CAR-T Cell Therapy in Patients With R/R Langerhans Cell Histiocytosis

Who this might be right for
Langerhans Cell Histiocytosis
Beijing Friendship Hospital 12
Testing effectiveness (Phase 2)Active Not RecruitingNCT03155620
What this trial is testing

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmAnn Arbor Stage III Non-Hodgkin LymphomaAnn Arbor Stage IV Non-Hodgkin Lymphoma+42 more
National Cancer Institute (NCI) 1,376
Early research (Phase 1)Active Not RecruitingNCT01552434
What this trial is testing

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Who this might be right for
Advanced Malignant NeoplasmCastleman DiseaseDigestive System Carcinoma+36 more
M.D. Anderson Cancer Center 155
Testing effectiveness (Phase 2)UnknownNCT04120519
What this trial is testing

Thalidomide, Cyclophosphamide and Dexamethasone for Recurrent/Refractory Adult Langerhans Cell Histiocytosis

Who this might be right for
Langerhans Cell Histiocytosis
Peking Union Medical College Hospital 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT02425904
What this trial is testing

Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis and LCH-related Disorders

Who this might be right for
Langerhans Cell Histiocytosis
Dana-Farber Cancer Institute 25
Testing effectiveness (Phase 2)Active Not RecruitingNCT04320888
What this trial is testing

Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial

Who this might be right for
Hematopoietic and Lymphatic System NeoplasmRecurrent EpendymomaRecurrent Ewing Sarcoma+35 more
National Cancer Institute (NCI) 1
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