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Results for “Refractory Malignant Solid Neoplasm”

274 trials

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Showing 20 of 274 results

Early research (Phase 1)Looking for participantsNCT06911008
What this trial is testing

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

Who this might be right for
Metastatic Malignant Solid NeoplasmRefractory Malignant Solid NeoplasmUnresectable Malignant Solid Neoplasm
Mayo Clinic 42
Testing effectiveness (Phase 2)Active Not RecruitingNCT06400251
What this trial is testing

Testing Ipatasertib as Potentially Targeted Treatment in Cancers With AKT Genetic Changes (MATCH - Subprotocol Z1K)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more
National Cancer Institute (NCI) 35
Early research (Phase 1)WithdrawnNCT00458744
What this trial is testing

Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment

Who this might be right for
Brain and Central Nervous System TumorsLeukemiaLymphoma+1 more
Children's Oncology Group
Testing effectiveness (Phase 2)Active Not RecruitingNCT06390826
What this trial is testing

Testing Sunitinib as Potentially Targeted Treatment in Cancers With cKIT Genetic Changes (MATCH - Subprotocol V)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more
National Cancer Institute (NCI) 10
Testing effectiveness (Phase 2)Ended earlyNCT05551117
What this trial is testing

Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors

Who this might be right for
Castration-Resistant Prostatic CancerAndrogen-Independent Prostatic CancerAndrogen-Insensitive Prostatic Cancer+14 more
MacroGenics 192
Early research (Phase 1)Ended earlyNCT05429502
What this trial is testing

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Who this might be right for
Neuroblastoma
Novartis Pharmaceuticals 12
Testing effectiveness (Phase 2)Study completedNCT02116777
What this trial is testing

Talazoparib and Temozolomide in Treating Younger Patients With Refractory or Recurrent Malignancies

Who this might be right for
Adult Solid NeoplasmChildhood Solid NeoplasmRecurrent Childhood Central Nervous System Neoplasm+3 more
National Cancer Institute (NCI) 40
Testing effectiveness (Phase 2)UnknownNCT02839954
What this trial is testing

CAR-pNK Cell Immunotherapy in MUC1 Positive Relapsed or Refractory Solid Tumor

Who this might be right for
Hepatocellular CarcinomaNon-small Cell Lung CancerPancreatic Carcinoma+4 more
PersonGen BioTherapeutics (Suzhou) Co., Ltd. 10
Testing effectiveness (Phase 2)Looking for participantsNCT06941272
What this trial is testing

Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

Who this might be right for
Malignant Neoplasm
Merck Sharp & Dohme LLC 50
Testing effectiveness (Phase 2)Active Not RecruitingNCT06360575
What this trial is testing

Testing Crizotinib as Potentially Targeted Treatment in Cancers With MET Exon 14 Deletion Genetic Changes (MATCH - Subprotocol C2)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmRefractory Lymphoma+2 more
National Cancer Institute (NCI) 35
Early research (Phase 1)Study completedNCT00931931
What this trial is testing

HSV1716 in Patients With Non-Central Nervous System (Non-CNS) Solid Tumors

Who this might be right for
RhabdomyosarcomaOsteosarcomaEwing Sarcoma+6 more
Timothy Cripe 18
Early research (Phase 1)Active Not RecruitingNCT02595931
What this trial is testing

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Who this might be right for
Metastatic Colorectal CarcinomaMetastatic Lung Small Cell CarcinomaMetastatic Malignant Solid Neoplasm+15 more
National Cancer Institute (NCI) 66
Testing effectiveness (Phase 2)Active Not RecruitingNCT03213652
What this trial is testing

Ensartinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With ALK or ROS1 Genomic Alterations (A Pediatric MATCH Treatment Trial)

Who this might be right for
Advanced Malignant Solid NeoplasmMalignant Solid NeoplasmRecurrent Ependymoma+30 more
National Cancer Institute (NCI) 13
Early research (Phase 1)Study completedNCT01169584
What this trial is testing

Safety Study of Recombinant Vaccinia Virus to Treat Refractory Solid Tumors in Pediatric Patients

Who this might be right for
NeuroblastomaRhabdomyosarcomaLymphoma+2 more
Jennerex Biotherapeutics 6
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439201
What this trial is testing

Testing Palbociclib (PD-0332991) as a Potential Targeted Treatment in Cancers With CCND1, 2, 3 Amplification (MATCH-Subprotocol Z1B)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+2 more
National Cancer Institute (NCI) 40
Testing effectiveness (Phase 2)Study completedNCT01614795
What this trial is testing

Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma

Who this might be right for
Childhood Alveolar Soft Part SarcomaChildhood AngiosarcomaChildhood Epithelioid Sarcoma+12 more
National Cancer Institute (NCI) 46
Early research (Phase 1)Looking for participantsNCT06223542
What this trial is testing

Studying TAK-243 in Patients With Advanced Cancer

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmIndolent Non-Hodgkin Lymphoma+3 more
National Cancer Institute (NCI) 95
Not applicableStudy completedNCT00521430
What this trial is testing

Donor Stem Cell Transplant After Conditioning Therapy in Treating Patients With Hematologic Cancer, Recurrent or Metastatic Solid Tumor, or Other Disease

Who this might be right for
LeukemiaLymphomaMultiple Myeloma and Plasma Cell Neoplasm+3 more
Asan Medical Center 30
Early research (Phase 1)Ended earlyNCT00101205
What this trial is testing

Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma

Who this might be right for
Angioimmunoblastic T-cell LymphomaB-cell Childhood Acute Lymphoblastic LeukemiaB-cell Chronic Lymphocytic Leukemia+24 more
National Cancer Institute (NCI) 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT04439175
What this trial is testing

Testing GDC-0032 (Taselisib) as a Potential Targeted Treatment in Cancers With PIK3CA Genetic Changes (MATCH-Subprotocol I)

Who this might be right for
Advanced LymphomaAdvanced Malignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+3 more
National Cancer Institute (NCI) 70
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