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Results for “Refractory Neurofibromatosis Type 1”

12 trials

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Showing 12 of 12 results

Early research (Phase 1)Looking for participantsNCT02390752
What this trial is testing

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

Who this might be right for
Neurofibroma, PlexiformPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, Promyelocytic, Acute+1 more
National Cancer Institute (NCI) 54
Early research (Phase 1)Study completedNCT02415153
What this trial is testing

Pomalidomide in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors

Who this might be right for
Neurofibromatosis Type 1Recurrent Childhood Brain Stem GliomaRecurrent Childhood Visual Pathway Glioma+2 more
National Cancer Institute (NCI) 29
Testing effectiveness (Phase 2)Looking for participantsNCT05735717
What this trial is testing

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Who this might be right for
Hematologic MalignancyAcute LeukemiaRemission+21 more
Masonic Cancer Center, University of Minnesota 70
Testing effectiveness (Phase 2)Study completedNCT01553149
What this trial is testing

Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma

Who this might be right for
Neurofibromatosis Type 1Recurrent Childhood Pilocytic AstrocytomaRecurrent Childhood Visual Pathway Glioma
National Cancer Institute (NCI) 75
Testing effectiveness (Phase 2)Active Not RecruitingNCT01089101
What this trial is testing

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

Who this might be right for
Low Grade GliomaRecurrent Childhood Pilocytic AstrocytomaRecurrent Neurofibromatosis Type 1+3 more
National Cancer Institute (NCI) 217
Testing effectiveness (Phase 2)Study completedNCT01661283
What this trial is testing

SARC016: Study of Everolimus With Bevacizumab to Treat Refractory Malignant Peripheral Nerve Sheath Tumors

Who this might be right for
Malignant Peripheral Nerve Sheath TumorsMPNSTSarcoma
Sarcoma Alliance for Research through Collaboration 25
Testing effectiveness (Phase 2)Active Not RecruitingNCT03363217
What this trial is testing

Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.

Who this might be right for
Low-grade GliomaPlexiform NeurofibromaCentral Nervous System Glioma
St. Justine's Hospital 114
Early research (Phase 1)Ended earlyNCT01552434
What this trial is testing

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Who this might be right for
Advanced Malignant NeoplasmCastleman DiseaseDigestive System Carcinoma+36 more
M.D. Anderson Cancer Center 154
Testing effectiveness (Phase 2)Active Not RecruitingNCT03190915
What this trial is testing

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

Who this might be right for
Juvenile Myelomonocytic LeukemiaNeurofibromatosis Type 1
National Cancer Institute (NCI) 10
Testing effectiveness (Phase 2)Study completedNCT01158651
What this trial is testing

Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas

Who this might be right for
Glioma
University of Alabama at Birmingham 23
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07743554
What this trial is testing

Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor

Who this might be right for
MPNST (Malignant Peripheral Nerve Sheath Tumor)
Girish Dhall, MD 23
Early research (Phase 1)UnknownNCT03634982
What this trial is testing

Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors

Who this might be right for
Solid Tumors
Revolution Medicines, Inc. 133