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Results for “Relapsed/Refractory Richter Transformation”

35 trials

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Showing 20 of 35 results

Early research (Phase 1)Active Not RecruitingNCT03479268
What this trial is testing

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

Who this might be right for
B-Cell Prolymphocytic LeukemiaRecurrent Chronic Lymphocytic LeukemiaRecurrent Diffuse Large B-Cell Lymphoma+15 more
City of Hope Medical Center 18
Testing effectiveness (Phase 2)WithdrawnNCT02285244
What this trial is testing

Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation

Who this might be right for
Prolymphocytic LeukemiaRecurrent Mantle Cell LymphomaRecurrent Small Lymphocytic Lymphoma+2 more
James Blachly
Early research (Phase 1)Not Yet RecruitingNCT07424833
What this trial is testing

APG-3288 in Relapsed/Refractory Blood Cancers

Who this might be right for
Relapsed/Refractory Hematological MalignanciesRelapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Leukemia (CLL/SLLRelapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL; Including Richter Transformation)+4 more
Ascentage Pharma Group Inc.
Early research (Phase 1)Enrolling By InvitationNCT07168486
What this trial is testing

CD19.20.22 CAR T-cells for Patients With Relapsed/Refractory B-Cell Lymphomas

Who this might be right for
B-Cell LymphomaDiffuse Large B Cell Lymphoma (DLBCL)Primary Mediastinal Large B-cell Lymphoma (PMBCL)+7 more
University of Maryland, Baltimore 15
Testing effectiveness (Phase 2)Active Not RecruitingNCT02846623
What this trial is testing

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

Who this might be right for
Chronic Lymphocytic LeukemiaRecurrent Transformed Chronic Lymphocytic LeukemiaRefractory Transformed Chronic Lymphocytic Leukemia+2 more
M.D. Anderson Cancer Center 50
Testing effectiveness (Phase 2)Ended earlyNCT05537766
What this trial is testing

Study of Brexucabtagene Autoleucel in Adults With Rare B-cell Malignancies

Who this might be right for
Relapsed/Refractory Waldenstrom MacroglobulinemiaRelapsed/Refractory Richter TransformationRelapsed/Refractory Burkitt Lymphoma+1 more
Kite, A Gilead Company 19
Testing effectiveness (Phase 2)Ended earlyNCT02138786
What this trial is testing

Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation

Who this might be right for
Richter's Transformation
Karyopharm Therapeutics Inc 27
Testing effectiveness (Phase 2)Study completedNCT01217749
What this trial is testing

Efficacy and Safety Study of PCI-32765 Combine With Ofatumumab in CLL

Who this might be right for
B-cell Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaProlymphocyctic Leukemia+1 more
Pharmacyclics LLC. 71
Testing effectiveness (Phase 2)Study completedNCT00304005
What this trial is testing

VNP40101M in Treating Patients With Richter Syndrome or Refractory or Relapsed Chronic Lymphocytic Leukemia or Other Lymphoproliferative Disorders

Who this might be right for
LeukemiaLymphoma
Vion Pharmaceuticals 35
Testing effectiveness (Phase 2)Ended earlyNCT04305444
What this trial is testing

Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas

Who this might be right for
Relapsed Chronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic LeukemiaDiffuse Large B Cell Lymphoma+2 more
Zhejiang DTRM Biopharma 55
Early research (Phase 1)Not Yet RecruitingNCT07539688
What this trial is testing

Phase I Clinical Study on the Safety and Efficacy of CY-219 CAR-T Cell Injection in the Treatment of Relapsed/Refractory B-Cell Lymphoma

Who this might be right for
Relapsed/Refractory B-cell LymphomaDiffuse Large B-cell LymphomaInert B-cell Lymphoma Transformed Into Large B-cell Lymphoma (Excluding Richter Transformation, THRLBCL, and BL)
Institute of Hematology & Blood Diseases Hospital, China 18
Testing effectiveness (Phase 2)Active Not RecruitingNCT06561425
What this trial is testing

A Study Evaluating the Safety and Efficacy of GLPG5101 (19CP02) in Participants With Non-Hodgkin Lymphoma

Who this might be right for
Relapsed/Refractory B-cell Non-Hodgkin LymphomaLymphomas Non-Hodgkin&Amp;Amp;#39;s B-Cell
Lakefront Biotherapeutics NV 130
Early research (Phase 1)Active Not RecruitingNCT05828589
What this trial is testing

BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies

Who this might be right for
Relapsed Non-Hodgkin LymphomaRefractory Non-Hodgkin LymphomaRelapsed Chronic Lymphocytic Leukemia+11 more
BeOne Medicines 112
Early research (Phase 1)Looking for participantsNCT04771572
What this trial is testing

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Who this might be right for
Non Hodgkin LymphomaRichter TransformationMultiple Myeloma+10 more
Newave Pharmaceutical Inc 100
Testing effectiveness (Phase 2)Study completedNCT02332980
What this trial is testing

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

Who this might be right for
Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue+20 more
Mayo Clinic 65
Testing effectiveness (Phase 2)Study completedNCT02420912
What this trial is testing

Nivolumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or High-Risk Untreated Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Richter Transformation

Who this might be right for
Loss of Chromosome 17pRecurrent Chronic Lymphocytic LeukemiaRecurrent Small Lymphocytic Lymphoma+3 more
M.D. Anderson Cancer Center 37
Early research (Phase 1)Study completedNCT02535286
What this trial is testing

Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation

Who this might be right for
Chronic Lymphocytic LeukemiaRichter Syndrome
TG Therapeutics, Inc. 27
Testing effectiveness (Phase 2)Ended earlyNCT03205046
What this trial is testing

Acalabrutinib and Vistusertib in Subjects With Relapsed/Refractory B-cell Malignancies

Who this might be right for
DLBCLRichter Syndrome
Acerta Pharma BV 25
Testing effectiveness (Phase 2)Study completedNCT00452374
What this trial is testing

Oxaliplatin, Fludarabine, Cytarabine and Rituximab in Richter's Syndrome, Refractory CLL and PLL

Who this might be right for
Leukemia
M.D. Anderson Cancer Center 48
Testing effectiveness (Phase 2)Study completedNCT02576990
What this trial is testing

Study of Pembrolizumab (MK-3475) in Participants With Relapsed or Refractory Primary Mediastinal Large B-cell Lymphoma or Relapsed or Refractory Richter Syndrome (MK-3475-170/KEYNOTE-170)

Who this might be right for
Mediastinal Large B-cell LymphomaRichter Syndrome
Merck Sharp & Dohme LLC 80
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