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Results for “Relapsed/Refractory Richter Transformation”

34 trials

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Showing 20 of 34 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT03162536
What this trial is testing

Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

Who this might be right for
Lymphoma, B-CellSmall Lymphocytic LymphomaChronic Lymphocytic Leukemia+6 more
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) 190
Testing effectiveness (Phase 2)Active Not RecruitingNCT04623541
What this trial is testing

Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome

Who this might be right for
Relapsed/Refractory Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaRichter's Syndrome+1 more
Genmab 195
Early research (Phase 1)Not Yet RecruitingNCT07451054
What this trial is testing

CD45BE-HSPC + CART-45 Cells

Who this might be right for
B-Cell Non-Hodgkin Lymphoma (NHL)Richter's TransformationT-Cell Non-Hodgkin Lymphoma+1 more
University of Pennsylvania 42
Testing effectiveness (Phase 2)Ended earlyNCT05537766
What this trial is testing

Study of Brexucabtagene Autoleucel in Adults With Rare B-cell Malignancies

Who this might be right for
Relapsed/Refractory Waldenstrom MacroglobulinemiaRelapsed/Refractory Richter TransformationRelapsed/Refractory Burkitt Lymphoma+1 more
Kite, A Gilead Company 19
Early research (Phase 1)Looking for participantsNCT04771572
What this trial is testing

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Who this might be right for
Non Hodgkin LymphomaRichter TransformationMultiple Myeloma+10 more
Newave Pharmaceutical Inc 100
Early research (Phase 1)Ended earlyNCT03778073
What this trial is testing

Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma

Who this might be right for
B-cell Non Hodgkin LymphomaRichter's Transformation
TG Therapeutics, Inc. 18
Early research (Phase 1)Active Not RecruitingNCT05828589
What this trial is testing

BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies

Who this might be right for
Relapsed Non-Hodgkin LymphomaRefractory Non-Hodgkin LymphomaRelapsed Chronic Lymphocytic Leukemia+11 more
BeOne Medicines 112
Early research (Phase 1)Study completedNCT02535286
What this trial is testing

Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation

Who this might be right for
Chronic Lymphocytic LeukemiaRichter Syndrome
TG Therapeutics, Inc. 27
Testing effectiveness (Phase 2)Study completedNCT02332980
What this trial is testing

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

Who this might be right for
Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Chronic Lymphocytic LeukemiaRecurrent Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue+20 more
Mayo Clinic 65
Testing effectiveness (Phase 2)Study completedNCT01217749
What this trial is testing

Efficacy and Safety Study of PCI-32765 Combine With Ofatumumab in CLL

Who this might be right for
B-cell Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaProlymphocyctic Leukemia+1 more
Pharmacyclics LLC. 71
Early research (Phase 1)Active Not RecruitingNCT03321643
What this trial is testing

Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma

Who this might be right for
Recurrent Diffuse Large B-Cell LymphomaRecurrent Transformed Non-Hodgkin LymphomaRefractory Diffuse Large B-Cell Lymphoma+3 more
National Cancer Institute (NCI)
Testing effectiveness (Phase 2)WithdrawnNCT02285244
What this trial is testing

Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation

Who this might be right for
Prolymphocytic LeukemiaRecurrent Mantle Cell LymphomaRecurrent Small Lymphocytic Lymphoma+2 more
James Blachly
Testing effectiveness (Phase 2)Ended earlyNCT02138786
What this trial is testing

Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation

Who this might be right for
Richter's Transformation
Karyopharm Therapeutics Inc 27
Testing effectiveness (Phase 2)Study completedNCT00304005
What this trial is testing

VNP40101M in Treating Patients With Richter Syndrome or Refractory or Relapsed Chronic Lymphocytic Leukemia or Other Lymphoproliferative Disorders

Who this might be right for
LeukemiaLymphoma
Vion Pharmaceuticals 35
Early research (Phase 1)Active Not RecruitingNCT03479268
What this trial is testing

Pevonedistat and Ibrutinib in Treating Participants With Relapsed or Refractory CLL or Non-Hodgkin Lymphoma

Who this might be right for
B-Cell Prolymphocytic LeukemiaRecurrent Chronic Lymphocytic LeukemiaRecurrent Diffuse Large B-Cell Lymphoma+15 more
City of Hope Medical Center 18
Early research (Phase 1)Enrolling By InvitationNCT07168486
What this trial is testing

CD19.20.22 CAR T-cells for Patients With Relapsed/Refractory B-Cell Lymphomas

Who this might be right for
B-Cell LymphomaDiffuse Large B Cell Lymphoma (DLBCL)Primary Mediastinal Large B-cell Lymphoma (PMBCL)+7 more
University of Maryland, Baltimore 15
Testing effectiveness (Phase 2)Ended earlyNCT04305444
What this trial is testing

Study of a Triple Combination Therapy, DTRM-555, in Patients With R/R CLL or R/R Non-Hodgkin's Lymphomas

Who this might be right for
Relapsed Chronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic LeukemiaDiffuse Large B Cell Lymphoma+2 more
Zhejiang DTRM Biopharma 55
Testing effectiveness (Phase 2)Active Not RecruitingNCT02846623
What this trial is testing

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

Who this might be right for
Chronic Lymphocytic LeukemiaRecurrent Transformed Chronic Lymphocytic LeukemiaRefractory Transformed Chronic Lymphocytic Leukemia+2 more
M.D. Anderson Cancer Center 50
Early research (Phase 1)Ended earlyNCT04978779
What this trial is testing

Evaluate VIP152 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia or Richter Syndrome

Who this might be right for
Relapsed Non Hodgkin LymphomaChronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic Leukemia+4 more
Vincerx Pharma, Inc. 6
Early research (Phase 1)Study completedNCT03263637
What this trial is testing

Study to Assess Safety, Tolerability, Pharmacokinetics and Antitumor Activity of AZD4573 in Relapsed/Refractory Haematological Malignancies

Who this might be right for
Relapsed or Refractory Haematological Malignancies IncludingAcute Myeloid LeukemiaAcute Lymphocytic Leukemia+8 more
AstraZeneca 44
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