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Results for “Relapsed or Refractory (r/r) B-cell Malignancies”

163 trials

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Showing 20 of 163 results

Testing effectiveness (Phase 2)WithdrawnNCT00845104
What this trial is testing

Fludarabine Phosphate, Rituximab, and Bevacizumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia That Has Relapsed or Not Responded To Treatment

Who this might be right for
B-cell Chronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic Leukemia
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
Early research (Phase 1)Active Not RecruitingNCT04447716
What this trial is testing

An Early Phase Study of Venetoclax, Lenalidomide, and Rituximab/Hyaluronidase in Slow-Growing Lymphomas That Have Come Back After Treatment or Have Not Responded to Treatment

Who this might be right for
Recurrent B-Cell Non-Hodgkin LymphomaRecurrent Follicular LymphomaRecurrent Indolent Adult Non-Hodgkin Lymphoma+5 more
Thomas Jefferson University 4
Large-scale testing (Phase 3)Active Not RecruitingNCT04680052
What this trial is testing

Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

Who this might be right for
Follicular LymphomaMarginal Zone Lymphoma
Incyte Corporation 654
Testing effectiveness (Phase 2)Looking for participantsNCT06526793
What this trial is testing

Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

Who this might be right for
B-cell Non-Hodgkin LymphomaFollicular Lymphoma (FL)Large B-Cell Lymphoma (LBCL)
AstraZeneca 240
Testing effectiveness (Phase 2)Study completedNCT02340936
What this trial is testing

Clinical Trial to Determinate Dose, Security and Efficacy or Lenalidomide and Rituximab (LR)-ESHAP in Patients With Diffuse Large B-cell Lymphoma

Who this might be right for
Diffuse Large B-cell Lymphoma
Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea 53
Testing effectiveness (Phase 2)Active Not RecruitingNCT04697940
What this trial is testing

Decitabine-primed Tandem CD19/CD20 CAR T Cells Treatment in r/r B-NHL

Who this might be right for
Relapsed and Refractory B-cell Non-Hodgkin's LymphomaDecitabine-primed Tandem CD19/CD20 CAR T Cells
Han weidong 33
Early research (Phase 1)Looking for participantsNCT06173518
What this trial is testing

CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL)

Who this might be right for
Relapsed or Refractory B Cell Acute Lymphoblastic LeukemiaRelapsed or Refractory B Cell Non-Hodgkin Lymphoma
Autolus Limited 30
Testing effectiveness (Phase 2)Looking for participantsNCT06635330
What this trial is testing

Safety and Efficacy of CAR T Cell Therapy in Patients with R/r B-ALL

Who this might be right for
Relapse/Refractory B-cell Acute Lymphoblastic Leukemia
Kara Yakhteh Tajhiz Azma Company 5
Testing effectiveness (Phase 2)Study completedNCT04030195
What this trial is testing

Dose-escalation Study of Safety of PBCAR20A in Subjects With r/r NHL or r/r CLL/SLL

Who this might be right for
Non-Hodgkin's Lymphoma, RelapsedChronic Lymphoid Leukemia in RelapseNon-Hodgkin's Lymphoma Refractory+6 more
Precision BioSciences, Inc. 18
Early research (Phase 1)WithdrawnNCT04094766
What this trial is testing

Safety and Efficacy of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy in R/R Acute B Lymphoblastic Leukemia

Who this might be right for
Refractory B Acute Lymphoblastic LeukemiaRelapse B Acute Lymphoblastic Leukemia
Second Affiliated Hospital of Xi'an Jiaotong University
Early research (Phase 1)UnknownNCT04653493
What this trial is testing

CD19 Targeted CAR T Cell Therapy in Patients With Relapsed/ Refractory B Cell Acute Lymphoblastic Leukaemia (ALL)

Who this might be right for
Relapsed B Cell Acute Lymphoblastic Leukemia (ALL)Refractory B Cell Acute Lymphoblastic Leukemia (ALL)
Sabz Biomedicals 22
Testing effectiveness (Phase 2)UnknownNCT02060656
What this trial is testing

Phase II Study Comparing LR-GEM to R-GEM-P in Second-line Treatment of Diffuse Large B-cell Lymphoma (LEGEND)

Who this might be right for
Diffuse Large B-Cell Lymphoma
Royal Marsden NHS Foundation Trust 92
Testing effectiveness (Phase 2)Looking for participantsNCT06479356
What this trial is testing

CD19-targeted CAR T Cells for Relapsed or Refractory (R/R) Large B-cell Lymphoma

Who this might be right for
Non-Hodgkin LymphomaLarge B-cell Lymphoma
Shanghai Ming Ju Biotechnology Co., Ltd. 12
Not applicableStudy completedNCT03751072
What this trial is testing

Efficacy and Toxicity of Blinatumomab in the French ATU for Adult BCP-ALL R/R, or With MRD+ (FRENCH-CYTO)

Who this might be right for
Acute Lymphoblastic Leukemia, in RelapseAcute Lymphoblastic Leukemia With Failed Remission
Group for Research in Adult Acute Lymphoblastic Leukemia 92
Not applicableStudy completedNCT04697160
What this trial is testing

Observational Retrospective Cohort Study of Systemic Therapies for R/R DLBCL

Who this might be right for
Diffuse Large B Cell Lymphoma
MorphoSys AG 3,573
Early research (Phase 1)Looking for participantsNCT03666000
What this trial is testing

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

Who this might be right for
Non-Hodgkin LymphomaB-cell Acute Lymphoblastic LeukemiaChronic Lymphocytic Leukemia+1 more
Imugene Limited 135
Not applicableUnknownNCT05495828
What this trial is testing

Orelabrutinib Therapy in Patients With r/r B-cell Lymphoma Intolerant to Other Bruton Tyrosine Kinase Inhibitors

Who this might be right for
B-cell Lymphoma
Peking University People's Hospital 30
Very early researchEnded earlyNCT04803123
What this trial is testing

Window Trial to Evaluate Molecular Response to PI3K Inhibition With Copanlisib in r/r Adult B-cell ALL

Who this might be right for
Leukemia, Acute Lymphocytic
Dorothy Sipkins, MD, PhD 3
Testing effectiveness (Phase 2)Study completedNCT03575325
What this trial is testing

Vyxeos(CPX-351) in Adults w R/R Acute Lymphoblastic Leukemia

Who this might be right for
Lymphoid LeukemiaAcute Lymphoblastic LeukemiaRefractory Acute Lymphoblastic Leukemia+1 more
H. Lee Moffitt Cancer Center and Research Institute 11
Testing effectiveness (Phase 2)Looking for participantsNCT05846750
What this trial is testing

Obinutuzumab in Combination With Lenalidomide in Relapsed or Refractory Marginal Zone Lymphoma

Who this might be right for
Marginal Zone Lymphoma
Institute of Hematology & Blood Diseases Hospital, China 59
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