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Results for “Resistant to Tyrosine Kinase Inhibitor Therapy”

20 trials

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Showing 20 of 20 results

Not applicableUnknownNCT05231863
What this trial is testing

Tyrosine Kinase Inhibitors (TKIs) in Trastuzumab Emtansine (T-DM1) Resistant HER2-positive Metastatic Breast Cancer: A Real-world Study

Who this might be right for
Breast Cancer
The First Affiliated Hospital with Nanjing Medical University 100
Testing effectiveness (Phase 2)Ended earlyNCT00449761
What this trial is testing

Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phase

Who this might be right for
Leukemia, Myeloid, Chronic
Novartis Pharmaceuticals 27
Not applicableLooking for participantsNCT04222335
What this trial is testing

Understanding and Overcoming the Early Adaptive Resistance to EGFR Tyrosine-kinase Inhibitors in Lung Cancer Patients

Who this might be right for
Lung Cancer, Nonsmall Cell
University Hospital, Toulouse 80
Not applicableActive Not RecruitingNCT05020275
What this trial is testing

Resistance to the Tyrosine Kinase Inhibitor Osimertinib and Pharmacokinetics in Non-small Cell Lung Cancer

Who this might be right for
Lung Cancer
Rennes University Hospital 60
Testing effectiveness (Phase 2)UnknownNCT02422719
What this trial is testing

Radotinib as 3rd or Later Line Therapy in CP-CML

Who this might be right for
Chronic Myeloid Leukemia
Ulsan University Hospital 73
Early research (Phase 1)Study completedNCT01456676
What this trial is testing

Nilotinib and LDE225 in the Treatment of Chronic or Accelerated Phase Myeloid Leukemia in Patients Who Developed Resistance to Prior Therapy

Who this might be right for
Philadelphia Chromosome Positive Chronic Myelogenous Leukemia
Novartis Pharmaceuticals 11
Testing effectiveness (Phase 2)Active Not RecruitingNCT02629692
What this trial is testing

Safety and Anti-leukemic Activity of Vodobatinib (K0706) for Treatment of Ph+ CML Resistant/Intolerant to ≥3 Prior CML Therapies

Who this might be right for
Healthy (For Part A)Chronic Myeloid Leukemia (for Part B and C)
Sun Pharma Advanced Research Company Limited 122
Testing effectiveness (Phase 2)Study completedNCT01914484
What this trial is testing

Phase I/II Study of Nilotinib/Ruxolitinb Therapy for TKI Resistant Ph-Leukemia

Who this might be right for
Chronic Phase Chronic Myeloid LeukemiaAccelerated Phase Chronic Myeloid LeukemiaBlastic Phase Chronic Myeloid Leukemia+2 more
University Health Network, Toronto 4
Large-scale testing (Phase 3)Study completedNCT00471328
What this trial is testing

Efficacy and Safety of Nilotinib (AMN107) Compared With Current Treatment Options in Patients With GIST Who Have Failed Both Imatinib and Sunitinib

Who this might be right for
Gastrointestinal Stromal Tumors
Novartis Pharmaceuticals 248
Not applicableUnknownNCT01700699
What this trial is testing

Impact of BRAFV600E Intratumor Heterogeneity in Thyroid Cancer Treated With Tyrosine Kinase Inhibitors

Who this might be right for
Differentiated Thyroid Cancer
University of Salerno 50
Early research (Phase 1)Study completedNCT01223898
What this trial is testing

To Evaluate the Effects of Multiple Doses of Nilotinib on the Pharmacokinetics and Metabolism of Midazolam in CML Patients With Additional Extension Phase to Evaluate the Safety of Nilotinib

Who this might be right for
Chronic Myeloid Leukemia
Novartis Pharmaceuticals 19
Testing effectiveness (Phase 2)Study completedNCT00511303
What this trial is testing

Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemia

Who this might be right for
Chronic Myeloid Leukemia
University of Bologna 200
Testing effectiveness (Phase 2)Ended earlyNCT00451035
What this trial is testing

Efficacy and Safety of LBH589 in Adult Patients With Refractory Chronic Myeloid Leukemia (CML) in Chronic Phase

Who this might be right for
Chronic Myeloid Leukemia in Chronic Phase
Novartis Pharmaceuticals 29
Early research (Phase 1)Study completedNCT00321581
What this trial is testing

AZD2171 to Treat Children and Adolescents With Solid Tumors or Acute Myelogenous Leukemia

Who this might be right for
Refractory or Recurrent Solid TumorsAcute Myelogenous Leukemia
National Cancer Institute (NCI) 18
Not applicableStudy completedNCT04546282
What this trial is testing

Resistance to Oral Therapy in Lung Cancer

Who this might be right for
Non Small Cell Lung Cancer
University Hospital, Montpellier 20
Large-scale testing (Phase 3)Study completedNCT02260505
What this trial is testing

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)

Who this might be right for
Gastrointestinal Stromal TumorsResected Gastrointestinal Stromal TumorsNon-metastatic+2 more
Centre Leon Berard 136
Testing effectiveness (Phase 2)Study completedNCT00117299
What this trial is testing

PTK787/ZK222584 in the Treatment of Metastatic Gastrointestinal Stromal Tumors Resistant to Imatinib

Who this might be right for
Sarcoma
University of Helsinki 45
Testing effectiveness (Phase 2)Ended earlyNCT03807479
What this trial is testing

Study in Patients With Chronic Leukemia

Who this might be right for
Leukemia, Myeloid, Chronic-Phase
GWT-TUD GmbH 18
Testing effectiveness (Phase 2)Ended earlyNCT04501614
What this trial is testing

Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Who this might be right for
Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL)Ph+ Mixed Phenotype Acute Leukemia (MPAL)Philadelphia Chromosome-Like ALL (Ph-like ALL)
Takeda 11
Large-scale testing (Phase 3)Study completedNCT01694277
What this trial is testing

Masitinib in Patients With Gastrointestinal Stromal Tumour After Progression With Imatinib

Who this might be right for
Gastrointestinal Stromal Tumors
AB Science 258