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Results for “STK11 Mutation”

21 trials

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Showing 20 of 21 results

Testing effectiveness (Phase 2)Active Not RecruitingNCT05445843
What this trial is testing

Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.

Who this might be right for
Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation
Novartis Pharmaceuticals 95
Testing effectiveness (Phase 2)Study completedNCT02352844
What this trial is testing

Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 Mutations

Who this might be right for
Solid MalignancySolid Tumor
Washington University School of Medicine 12
Testing effectiveness (Phase 2)Looking for participantsNCT06128551
What this trial is testing

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)Colorectal CancerPancreatic Ductal Adenocarcinoma
Revolution Medicines, Inc. 534
Testing effectiveness (Phase 2)Looking for participantsNCT05887492
What this trial is testing

Study of TNG260 and an Anti-PD Antibody in STK11 Mutated Solid Tumors

Who this might be right for
Non Small Cell Lung CancerSolid Tumors, AdultLung Cancer+1 more
Tango Therapeutics, Inc. 126
Testing effectiveness (Phase 2)Looking for participantsNCT07207395
What this trial is testing

Orally Administered JBI-802 Alone or in Combination With Pembrolizumab for Patients With Non-small Cell Lung Cancer With an STK11 Mutation.

Who this might be right for
Lung Cancer (NSCLC)
The Christ Hospital 30
Testing effectiveness (Phase 2)Ended earlyNCT04265534
What this trial is testing

KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC

Who this might be right for
Non-Small Cell Lung CancerNon-squamous Non-small-cell Lung CancerNon-Squamous Non-Small Cell Neoplasm of Lung+3 more
Calithera Biosciences, Inc 40
Not applicableUnknownNCT01987518
What this trial is testing

French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and Hyperplastic Polyposis

Who this might be right for
Quality of Life
Hôpital Edouard Herriot 350
Testing effectiveness (Phase 2)Looking for participantsNCT05276726
What this trial is testing

JAB-21822 in Advanced or Metastatic NSCLC With KRAS p.G12C and STK11 Co-mutation and Wild-type KEAP1

Who this might be right for
Non-small Cell Lung Cancer
Allist Pharmaceuticals, Inc. 104
Testing effectiveness (Phase 2)Looking for participantsNCT06124963
What this trial is testing

WX390 Combined With Toripalimab in Patients With Advanced Gastric-type Endocervical Adenocarcinoma With STK11 Mutations

Who this might be right for
Gastric Type Adenocarcinoma (GAS) With STK11 Mutation
Shanghai Jiatan Pharmatech Co., Ltd 20
Testing effectiveness (Phase 2)Looking for participantsNCT05807048
What this trial is testing

Daratumumab in STK11 Mutated NSCLC

Who this might be right for
Non-small Cell Lung Cancer With STK11/LKB1 Mutation
NYU Langone Health 14
Large-scale testing (Phase 3)Looking for participantsNCT06008093
What this trial is testing

Investigate the Efficacy of Durvalumab Plus Tremelimumab in Combination With Chemotherapy Compared With Pembrolizumab in Combination With Chemotherapy in Metastatic NSCLC Patients With Non-squamous Histology Who Have Mutations and/or Co-mutations in STK11, KEAP1, or KRAS

Who this might be right for
Carcinoma, Non-Small-Cell Lung
AstraZeneca 280
Large-scale testing (Phase 3)Not Yet RecruitingNCT06335355
What this trial is testing

A Phase II/III Study of Adebrelimab in Combination With SHR-8068 and Chemotherapy in Advanced or Metastatic NSCLC Patients

Who this might be right for
Non-squamous Non-small Cell Lung Cancer
Shanghai Shengdi Pharmaceutical Co., Ltd 401
Testing effectiveness (Phase 2)Active Not RecruitingNCT03785249
What this trial is testing

Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1

Who this might be right for
Advanced CancerMetastatic CancerMalignant Neoplastic Disease
Mirati Therapeutics Inc. 731
Testing effectiveness (Phase 2)Study completedNCT04173507
What this trial is testing

Combination Treatment (Talazoparib Plus Avelumab) for Stage IV or Recurrent Non-Squamous Non-Small Cell Lung Cancer With STK11 Gene Mutation (A LUNG-MAP Treatment Trial)

Who this might be right for
Advanced Lung Non-Squamous Non-Small Cell CarcinomaRecurrent Lung Non-Squamous Non-Small Cell CarcinomaStage IV Lung Cancer AJCC v8+2 more
SWOG Cancer Research Network 47
Not applicableLooking for participantsNCT06712095
What this trial is testing

Video Capsule Examination in Patients With Lynch Syndrome

Who this might be right for
Lynch SyndromeLi Fraumeni SyndromePTEN Hamartoma Syndrome+7 more
Royal Marsden NHS Foundation Trust 25
Testing effectiveness (Phase 2)Looking for participantsNCT06331650
What this trial is testing

A Single-arm Pilot Study of First-line Treatment With Carbognilumab Combined With Chemotherapy in Patients With STK11-mutated Advanced or Postoperative Recurrent Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
Guangzhou Institute of Respiratory Disease 30
Not applicableStudy completedNCT04257045
What this trial is testing

Factors Influencing Cascade Testing Among Women With Hereditary Gynecological Cancers and Their Relatives

Who this might be right for
Breast CarcinomaDeleterious CDH1 Gene MutationDeleterious DICER1 Gene Mutation+6 more
M.D. Anderson Cancer Center 46
Not applicableEnded earlyNCT04698681
What this trial is testing

NGS Screening Protocol to Detect Mutation of KEAP1 or NRF2/NFE2L2 Genes for the KEAPSAKE (CX-839-014) Trial

Who this might be right for
Non-Small Cell Lung CancerNon-squamous Non-small-cell Lung CancerNon-Squamous Non-Small Cell Neoplasm of Lung+3 more
Calithera Biosciences, Inc 20
Testing effectiveness (Phase 2)Ended earlyNCT05469178
What this trial is testing

A Clinical Study of Bemcentinib With Standard of Care Chemoimmunotherapy in Untreated Advanced/Metastatic Non-small Cell Lung Cancer Patients With a Mutation in the STK11 Gene

Who this might be right for
Carcinoma, Non-Small-Cell Lung
BerGenBio ASA 26
Early research (Phase 1)Active Not RecruitingNCT05462717
What this trial is testing

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Who this might be right for
Non-Small Cell Lung Cancer (NSCLC)Colorectal Cancer (CRC)Pancreatic Ductal Adenocarcinoma+1 more
Revolution Medicines, Inc. 222
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