Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe”

21,190 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 21,190 results

Not applicableUnknownNCT04047524
What this trial is testing

A Trimodal Prehabilitation Study for Patients Undergoing Major Abdominal Surgery

Who this might be right for
Pilot Study
Shira Baram 30
Large-scale testing (Phase 3)Not Yet RecruitingNCT07231523
What this trial is testing

EFG vs IVIG in TAMG

Who this might be right for
EfgartigimodIntravenous ImmunoglobulinMyasthenia Gravis Associated With Thymoma
Shanghai Zhongshan Hospital 64
Testing effectiveness (Phase 2)Study completedNCT00091182
What this trial is testing

Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment

Who this might be right for
Childhood Central Nervous System Germ Cell TumorChildhood Extragonadal Germ Cell TumorChildhood Hepatoblastoma+23 more
National Cancer Institute (NCI) 180
Not applicableStudy completedNCT06447259
What this trial is testing

Drug Burden Index is Associated With Malnutrition in Community-dwelling Dementia Patients

Who this might be right for
Malnutrition SevereDementiaDrug Use+1 more
Sultan Keskin Demircan 415
Very early researchLooking for participantsNCT05632562
What this trial is testing

Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma

Who this might be right for
High Grade Glioma
University of Alabama at Birmingham 20
Testing effectiveness (Phase 2)Active Not RecruitingNCT06004661
What this trial is testing

Study of Lutetium (177Lu) Vipivotide Tetraxetan in mCRPC Participants With Moderately and Severely Impaired and With Normal Renal Function

Who this might be right for
Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Novartis Pharmaceuticals 23
Not applicableStudy completedNCT04621786
What this trial is testing

Electroconvulsive Therapy Amplitude Titration

Who this might be right for
Major Depressive Disorder
University of New Mexico 41
Testing effectiveness (Phase 2)Study completedNCT03561870
What this trial is testing

Olaparib in Recurrent IDH-mutant Glioma

Who this might be right for
Recurrent IDHMutant High Grade Glioma
Hospices Civils de Lyon 35
Not applicableStudy completedNCT02581969
What this trial is testing

Extension at 10 Years of the: "Observational Study Evaluating Efficacy and Costs of Secondary Prophylaxis vs On-demand Therapy With Kogenate Bayer in Patients With Severe Haemophilia A."

Who this might be right for
Hemophilia A
Bayer 43
Large-scale testing (Phase 3)Study completedNCT00167154
What this trial is testing

Risperidone and Suicidality in Major Depressive Disorder

Who this might be right for
Depression
University of Alabama at Birmingham 30
Not applicableStudy completedNCT01244854
What this trial is testing

Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness

Who this might be right for
Bipolar DisorderSchizophreniaMajor Depressive Disorder+2 more
VA Office of Research and Development 55
Not applicableStudy completedNCT01219205
What this trial is testing

Major and Macular Branched Retinal Venous Occlusion

Who this might be right for
Macular Edema
Hallym University Medical Center 46
Testing effectiveness (Phase 2)Study completedNCT06102005
What this trial is testing

Dose Ranging Study of Lunsekimig Compared With Placebo-control in Adult Participants With Moderate-to-severe Asthma

Who this might be right for
Asthma
Sanofi 685
Large-scale testing (Phase 3)Study completedNCT06124794
What this trial is testing

The Efficacy and Safety of Protoxin in Subjects With Moderate to Severe Glabellar Lines

Who this might be right for
Glabellar Frown Lines
Protox Inc. 155
Testing effectiveness (Phase 2)Study completedNCT00070694
What this trial is testing

An Investigation of the Antidepressant Efficacy of the 5-HT2A Antagonist, M100907, in Combination With Citalopram in Treatment Resistant Depression

Who this might be right for
Depressive Disorder
National Institute of Mental Health (NIMH) 96
Not applicableStudy completedNCT05391594
What this trial is testing

Effect of Trunk Support on Academic Engagement of Children With Severe Disability

Who this might be right for
Cerebral PalsyTraumatic Brain InjuryMetabolic Disease+1 more
University of Hartford 10
Not applicableStudy completedNCT02641366
What this trial is testing

Electromagnetic Tracking to Measure Tremor

Who this might be right for
Tremor
University of Florida 20
Large-scale testing (Phase 3)Active Not RecruitingNCT06325566
What this trial is testing

Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain

Who this might be right for
Degenerative Disc Disease
Mesoblast, Ltd. 300
Not applicableEnrolling By InvitationNCT07207031
What this trial is testing

Acute Kidney Injury - Epidemiology in Intensive Care Unit Patients 2: an International Multicenter Cohort Study

Who this might be right for
Kidney Injury, AcuteIntensive Care Unit ICU
University Hospital, Ghent 10,642
Testing effectiveness (Phase 2)Looking for participantsNCT07570862
What this trial is testing

A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

Who this might be right for
Lupus NephritisSystemic Lupus ErythematosusSLE - Systemic Lupus Erythematosus+2 more
Fate Therapeutics 53
Next Page