Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe Alzheimer Disease”

113 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 113 results

Not applicableLooking for participantsNCT07402356
What this trial is testing

VR Pupillometry in Cognitive Impairment

Who this might be right for
Alzheimer s DiseaseMajor Depressive Disorder (MDD)Mild Cognitive Impairment+1 more
Max-Planck-Institute of Psychiatry 140
Not applicableLooking for participantsNCT06539169
What this trial is testing

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

Who this might be right for
Alpha-ThalassemiaBeta-ThalassemiaAmyloidosis+14 more
xCures 1,000
Large-scale testing (Phase 3)Study completedNCT01404169
What this trial is testing

A 24-weeks, Multi-center, Randomized, Double-blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Donepezil Hydrochloride in Chinese Subjects With Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Type Dementia
Eisai Limited 260
Not applicableNot Yet RecruitingNCT07200739
What this trial is testing

Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)

Who this might be right for
Dementia (Diagnosis)Alzheimer Dementia (AD)Vascular Dementia (VaD)+6 more
Zealand University Hospital 440
Not applicableStudy completedNCT02761707
What this trial is testing

Biomarkers in Neural Disorders

Who this might be right for
Parkinson's DiseaseAlzheimer's DiseaseProgressive Supranuclear Palsy+6 more
University of Pennsylvania 54
Large-scale testing (Phase 3)Ended earlyNCT00679627
What this trial is testing

Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Janssen Research & Development, LLC 2,051
Not applicableUnknownNCT05048966
What this trial is testing

Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons

Who this might be right for
Traumatic Brain InjuryMild Traumatic Brain InjuryAlzheimer's Disease+3 more
Kessler Foundation 360
Post-approval studies (Phase 4)Study completedNCT00401167
What this trial is testing

Memantine for Agitation and Aggression in Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Sunnybrook Health Sciences Centre 31
Testing effectiveness (Phase 2)Looking for participantsNCT06745583
What this trial is testing

Assess the Safety of EI-1071 and the Effects of EI-1071 on Neuroinflammation in Alzheimer's Disease Patients

Who this might be right for
Mild, Moderate, or Severe Alzheimer's Disease
Elixiron Immunotherapeutics Inc. 15
Post-approval studies (Phase 4)UnknownNCT05430867
What this trial is testing

Efficacy and Safety of Memantine and Sodium Oligomannate in Patients With Moderate to Severe Alzheimer's Disease

Who this might be right for
TreatmentEfficacySafety+1 more
First Affiliated Hospital Xi'an Jiaotong University 150
Early research (Phase 1)Study completedNCT00824590
What this trial is testing

A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function

Who this might be right for
Alzheimer's DiseaseHuntington's Disease
Pfizer 20
Not applicableNot Yet RecruitingNCT06993285
What this trial is testing

ADvanced ALzheimer Disease and Effects of Protologic and LAnguage Rehabilitation Tools in Nursing Home (ADALPA)

Who this might be right for
Alzheimer Disease
Central Hospital, Nancy, France 9
Post-approval studies (Phase 4)Study completedNCT07417670
What this trial is testing

Satisfaction With Orodispersible vs Conventional Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer Disease
Carnot Laboratories 105
Not applicableStudy completedNCT05407272
What this trial is testing

Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care

Who this might be right for
Alzheimer Disease, Late OnsetStrokeHeart Failure+5 more
Wen-Shiou Pan 60
Testing effectiveness (Phase 2)Study completedNCT00325728
What this trial is testing

Efficacy and Safety of Ramelteon in Subjects With Mild to Moderate Alzheimer's Disease

Who this might be right for
Chronic Insomnia
Takeda 74
Post-approval studies (Phase 4)UnknownNCT00866060
What this trial is testing

Donepezil and Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Moderate to Severe Alzheimer's Disease
King's College London 800
Testing effectiveness (Phase 2)Study completedNCT05074498
What this trial is testing

Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of TB006 in Participants With Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
TrueBinding, Inc. 154
Large-scale testing (Phase 3)Ended earlyNCT00857233
What this trial is testing

Safety and Tolerability of Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
H. Lundbeck A/S 297
Not applicableUnknownNCT05976659
What this trial is testing

Home-based Neuromodulation to Target Depression And Memory Symptoms in Older Adults

Who this might be right for
Major Depressive DisorderAlzheimer DiseaseDementia+3 more
Hebrew SeniorLife 20
Testing effectiveness (Phase 2)Study completedNCT03765762
What this trial is testing

Assess the Safety of GRF6019 Infusions in Subjects With Severe Alzheimer's Disease

Who this might be right for
Severe Alzheimer Disease
Alkahest, Inc. 26
Load More Results