Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Severe Alzheimer Disease”

109 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 109 results

Not applicableTemporarily pausedNCT04031469
What this trial is testing

A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease

Who this might be right for
Gut MicrobiomeGastrointestinal MicrobiomeAutism+77 more
ProgenaBiome 1,000
Large-scale testing (Phase 3)Study completedNCT00322153
What this trial is testing

The Safety and Efficacy of Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Dementia of the Alzheimer's Type
Forest Laboratories 677
Large-scale testing (Phase 3)Ended earlyNCT01066546
What this trial is testing

An Extension To The B1451006 Protocol To Evaluate The Safety and Efficacy of Dimebon In Subjects With Moderate-to-Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Pfizer 5
Post-approval studies (Phase 4)Study completedNCT02097056
What this trial is testing

Safety and Efficacy of Donepezil HCl 23 mg in Patients With Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Eisai Korea Inc. 171
Testing effectiveness (Phase 2)Study completedNCT05074498
What this trial is testing

Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of TB006 in Participants With Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
TrueBinding, Inc. 154
Large-scale testing (Phase 3)Not Yet RecruitingNCT05303701
What this trial is testing

GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD)

Who this might be right for
Moderate to Severe Alzheimer's Disease
Samsung Pharmaceutical Co., Ltd. 750
Large-scale testing (Phase 3)Ended earlyNCT00488670
What this trial is testing

Escitalopram and Depression in Elderly Alzheimer's Patients

Who this might be right for
Depressive Disorder
University of British Columbia 50
Post-approval studies (Phase 4)Study completedNCT00234637
What this trial is testing

Rivastigmine Monotherapy and Combination Therapy With Memantine in Patients With Moderately Severe Alzheimer's Disease Who Failed to Benefit From Previous Cholinesterase Inhibitor Treatment

Who this might be right for
Alzheimer's Disease
Novartis 204
Not applicableUnknownNCT03866018
What this trial is testing

Contribution of Physical Activity to Self-esteem and Motivation in Older Adults With Minor to Major Cognitive Disorders Such as Alzheimer's Disease or Related Disorders

Who this might be right for
Cognitive Disorders
Centre Hospitalier Universitaire de Nice 20
Testing effectiveness (Phase 2)Study completedNCT03765762
What this trial is testing

Assess the Safety of GRF6019 Infusions in Subjects With Severe Alzheimer's Disease

Who this might be right for
Severe Alzheimer Disease
Alkahest, Inc. 26
Large-scale testing (Phase 3)Study completedNCT01876823
What this trial is testing

Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment

Who this might be right for
Mild Cognitive ImpairmentMajor Depressive DisorderAlzheimer's Disease
New York State Psychiatric Institute 60
Post-approval studies (Phase 4)Looking for participantsNCT05004987
What this trial is testing

Aβ Dynamics in LLMD

Who this might be right for
Alzheimer DiseaseMajor Depressive Disorder
NYU Langone Health 60
Post-approval studies (Phase 4)Ended earlyNCT00649220
What this trial is testing

Memantine and Antipsychotics Use

Who this might be right for
Alzheimer's Disease
Merz Pharmaceuticals GmbH 19
Not applicableLooking for participantsNCT04992195
What this trial is testing

Impact of COVID-19 Vaccines on Cerebrovascular Health

Who this might be right for
StrokeStroke, AcuteStroke, Ischemic+7 more
Chinese University of Hong Kong 500
Not applicableEnrolling By InvitationNCT07239843
What this trial is testing

Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychiatric Symptoms in Neurodegenerative Diseases and Mental Disorders

Who this might be right for
Major Depressive Disorder (MDD)Schizophenia DisorderBipolar 1 Disorder+4 more
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau 1,310
Post-approval studies (Phase 4)Study completedNCT00800709
What this trial is testing

Memantine and Changes of Biological Markers and Brain PET Imaging in Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
Shanghai Mental Health Center 26
Not applicableStudy completedNCT01081743
What this trial is testing

Effectiveness of Care Management in Alzheimer Patients

Who this might be right for
Alzheimer Disease or Associated DisorderMild to Moderately Severe Dementia
Institut de Sante Publique, d'Epidemiologie et de Developpement 270
Not applicableNot Yet RecruitingNCT06993285
What this trial is testing

ADvanced ALzheimer Disease and Effects of Protologic and LAnguage Rehabilitation Tools in Nursing Home (ADALPA)

Who this might be right for
Alzheimer Disease
Central Hospital, Nancy, France 9
Not applicableEnded earlyNCT01001637
What this trial is testing

Efficacy and Safety of Curcumin Formulation in Alzheimer's Disease

Who this might be right for
Alzheimer Disease
Jaslok Hospital and Research Centre 26
Large-scale testing (Phase 3)Ended earlyNCT00857649
What this trial is testing

Efficacy and Safety of Memantine in Moderate to Severe Alzheimer's Disease

Who this might be right for
Alzheimer's Disease
H. Lundbeck A/S 369
Load More Results